Zebrafish-Based Discovery of Antiseizure Compounds from the North Sea: Isoquinoline Alkaloids TMC-120A and TMC-120B

Autor: Daniëlle Copmans, Sara Kildgaard, Silas A. Rasmussen, Monika Ślęzak, Nina Dirkx, Michèle Partoens, Camila V. Esguerra, Alexander D. Crawford, Thomas O. Larsen, Peter A. M. de Witte

Publikováno v: Marine Drugs, Vol 17, Iss 11, p 607 (2019)

There is a high need for the development of new and improved antiseizure drugs (ASDs) to treat epilepsy. Despite the potential of marine natural products (MNPs), the EU marine biodiscovery consortium PharmaSea has made the only effort to date to perf

Externí odkaz: https://doaj.org/article/f55527d449b24d7bb5f42251a1982621

A Concise Total Synthesis of the Fungal Isoquinoline Alkaloid TMC-120B

Autor: Ahmad K. Haidar, Niels D. Kjeldsen, Nikolaj S. Troelsen, Viola Previtali, Kasper P. Lundquist, Thomas O. Larsen, Mads H. Clausen

Publikováno v: Molecules, Vol 27, Iss 2, p 521 (2022)

Recent reports of antiepileptic activity of the fungal alkaloid TMC-120B have renewed the interest in this natural product. Previous total syntheses of TMC-120B comprise many steps and have low overall yields (11–17 steps, 1.5–2.9% yield). Thus,

Externí odkaz: https://doaj.org/article/9ff3f2753c5f422ebf7d0272b8ae2f5e

Zebrafish-based discovery of antiseizure compounds from the north sea: Isoquinoline alkaloids TMC-120A and TMC-120B

Autor: Silas Anselm Rasmussen, Sara Kildgaard, Monika Ślęzak, Camila V. Esguerra, Thomas Ostenfeld Larsen, Daniëlle Copmans, Peter de Witte, Michèle Partoens, Nina Dirkx, Alexander D. Crawford

Publikováno v: Copmans, D, Kildgaard, S, Rasmussen, S A, Ślezak, M, Dirkx, N, Partoens, M, Esguerra, C V, Crawford, A D, Larsen, T O & De Witte, P A M 2019, ' Zebrafish-based discovery of antiseizure compounds from the north sea: Isoquinoline alkaloids TMC-120A and TMC-120B ', Marine Drugs, vol. 17, no. 11, 607 . https://doi.org/10.3390/md17110607
Marine Drugs
Volume 17
Issue 11
Marine Drugs, Vol 17, Iss 11, p 607 (2019)

There is a high need for the development of new and improved antiseizure drugs (ASDs) to treat epilepsy. Despite the potential of marine natural products (MNPs), the EU marine biodiscovery consortium PharmaSea has made the only effort to date to perf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::163678ca13c9692a5812464006f13c1d
https://orbit.dtu.dk/en/publications/1cba1001-99b4-4b69-92ff-cfda39e4aa59

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Zebrafish-based discovery of antiseizure compounds from the north sea: Isoquinoline alkaloids TMC-120A and TMC-120B

Autor: Copmans, Daniëlle, Kildgaard, Sara, Rasmussen, Silas A., Ślęzak, Monika, Dirkx, Nina, Partoens, Michèle, Esguerra, Camila Vicencio, Crawford, Alexander Dettmar, Larsen, Thomas O., de Witte, Peter A.M.

Publikováno v: Copmans, Daniëlle Kildgaard, Sara Rasmussen, Silas A. Ślęzak, Monika Dirkx, Nina Partoens, Michèle Esguerra, Camila Vicencio Crawford, Alexander Dettmar Larsen, Thomas O. de Witte, Peter A.M. . Zebrafish-based discovery of antiseizure compounds from the north sea: Isoquinoline alkaloids TMC-120A and TMC-120B. Marine Drugs. 2019, 17:607(11), 1-20
Marine Drugs

Externí odkaz: http://hdl.handle.net/10852/76312
https://www.duo.uio.no/bitstream/handle/10852/76312/2/marinedrugs-17-00607.pdf