Zobrazeno 1 - 10
of 3 337
pro vyhledávání: '"tissue resident"'
Publikováno v:
Molecular Oncology, Vol 18, Iss 7, Pp 1739-1758 (2024)
Macrophages are innate immune cells that play key roles during both homeostasis and disease. Depending on the microenvironmental cues sensed in different tissues, macrophages are known to acquire specific phenotypes and exhibit unique features that,
Externí odkaz:
https://doaj.org/article/102a7d6cbe1d40af8d442682b439fc17
Autor:
Simei Go, Constantinos Demetriou, Giampiero Valenzano, Sophie Hughes, Simone Lanfredini, Helen Ferry, Edward Arbe-Barnes, Shivan Sivakumar, Rachel Bashford-Rogers, Mark R Middleton, Somnath Mukherjee, Jennifer Morton, Keaton Jones, Eric O Neill
Publikováno v:
eLife, Vol 13 (2024)
The immunosuppressive microenvironment in pancreatic ductal adenocarcinoma (PDAC) prevents tumor control and strategies to restore anti-cancer immunity (i.e. by increasing CD8 T-cell activity) have had limited success. Here, we demonstrate how induci
Externí odkaz:
https://doaj.org/article/71c5b8de40e04161b42d0234f53620ea
Autor:
Xue-Wu Wei, Chang Lu, Yi-Chen Zhang, Xue Fan, Chong-Rui Xu, Zhi-Hong Chen, Fen Wang, Xiao-Rong Yang, Jia-Yi Deng, Ming-Yi Yang, Qing Gou, Shi-Qi Mei, Wei-Chi Luo, Ri-Wei Zhong, Wen-Zhao Zhong, Jin-Ji Yang, Xu-Chao Zhang, Hai-Yan Tu, Yi-Long Wu, Qing Zhou
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
Metabolism reprogramming within the tumor microenvironment (TME) can have a profound impact on immune cells. Identifying the association between metabolic phenotypes and immune cells in lung adenocarcinoma (LUAD) may reveal mechanisms of resistance t
Externí odkaz:
https://doaj.org/article/69ff1c8e561c44988808d82daaa7d78f
Autor:
Alina Sprenger-Svačina, Martin K. R. Svačina, Tong Gao, Rodney M. Ritzel, Louise D. McCullough, Kazim A. Sheikh, Gang Zhang
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionThe current study focuses on understanding the functional role of different subsets of endoneurial macrophages in autoimmune polyneuropathies (AP) and traumatic peripheral nerve injury (TPNI), which holds potential for clinical applicatio
Externí odkaz:
https://doaj.org/article/e2dbca4db85a45b68d916d1b933985fc
Publikováno v:
Cancer Medicine, Vol 13, Iss 21, Pp n/a-n/a (2024)
ABSTRACT Introduction Macrophages are essential in maintaining homeostasis, combating infections, and influencing the process of various diseases, including cancer. Macrophages originate from diverse lineages: Notably, tissue‐resident macrophages (
Externí odkaz:
https://doaj.org/article/ceeb3179e15b473193660cb9f6a6b460
Autor:
Yangxuan Wei, Xiaoyan Liang, Yulin Wu, Jiayu Zhang, Xiaohui Cui, Yutong Wu, Delin Zhu, Ping Lv, Wei Meng, Wenbin Li, Haitao Shen
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 285, Iss , Pp 117082- (2024)
Aflatoxin G1 (AFG1) is a mycotoxin commonly found in agricultural products, including dried fruits, meat, and milk products. Oral AFG1 administration induced tumor necrosis factor (TNF)-α-dependent chronic pulmonary inflammation, promoting AFG1-indu
Externí odkaz:
https://doaj.org/article/ab80d31671e9442ba5f5e39135cc5e88
Publikováno v:
Inflammation and Regeneration, Vol 44, Iss 1, Pp 1-6 (2024)
Abstract Background Cancer tissues contain a wide variety of immune cells that play critical roles in suppressing or promoting tumor progression. Macrophages are one of the most predominant populations in the tumor microenvironment and are composed o
Externí odkaz:
https://doaj.org/article/9912d2d95e9f4fbbb3ee8af65884dd82
Autor:
Mari Murakami
Publikováno v:
Inflammation and Regeneration, Vol 44, Iss 1, Pp 1-12 (2024)
Abstract Tissue-resident memory T cells (TRM) serve as the frontline of host defense, playing a critical role in protection against invading pathogens. This emphasizes their role in providing rapid on-site immune responses across various organs. The
Externí odkaz:
https://doaj.org/article/fa9f1d82823244c7a8352cd63398c40c
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundLeukemia is a prevalent pediatric life-threatening hematologic malignancy with a poor prognosis. Targeting immune checkpoints (ICs) to reverse T cell exhaustion is a potentially effective treatment for leukemia. Tissue resident memory T (TR
Externí odkaz:
https://doaj.org/article/be6fc5d6b8e548439fd93cc285e6e06e
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Since CD4+ T cells are essential for regulating adaptive immune responses and for long lasting mucosal protection, changes in CD4+ T cell numbers and function are likely to affect protective immunity. What remains unclear is whether CD4+ T cell compo
Externí odkaz:
https://doaj.org/article/d5ec72daeb384a47b9b3b5980534d739