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Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis

Autor: Rute M. M. Ferreira, Axel Behrens, Corina Cotoi, Hendrik A. Messal, Silvanus Alt, Christopher Gribben, Victoria M.-Y. Wang, Guillaume Salbreux

Publikováno v: Messal, H A, Alt, S, Ferreira, R M M, Gribben, C, Wang, V M Y, Cotoi, C G, Salbreux, G & Behrens, A 2019, ' Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis ', Nature, vol. 566, no. 7742, pp. 126-130 . https://doi.org/10.1038/s41586-019-0891-2

Tubular epithelia are a basic building block of organs and a common site of cancer occurrence1–4. During tumorigenesis, transformed cells overproliferate and epithelial architecture is disrupted. However, the biophysical parameters that underlie th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e453d4d98f0a8648235e0acaeb94d76
https://doi.org/10.1038/s41586-019-0891-2

Combinatorial patterns of graded RhoA activation and uniform F-actin depletion promote tissue curvature

Autor: Denk-Lobnig, Marlis, Heer, Natalie C, Martin, Adam C

During development, gene expression regulates cell mechanics and shape to sculpt tissues. Epithelial folding proceeds through distinct cell shape changes that occur in different regions of a tissue. Here, using quantitative imaging inDrosophila melan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5013cefd8a78cfe3e441d132f821aea1
https://doi.org/10.1101/2020.04.15.043893

Combinatorial patterns of graded RhoA activation and uniform F-actin depletion promote tissue curvature

Autor: Grace Lim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8973ac9c5c70a0158e6ec09474bd8f6
https://doi.org/10.1242/prelights.19768