A simple and facile iodination method of didechlorotiacumicin B and aromatic compounds

Autor: Haibo Zhang, Li-Ping Zhang, Imran Khan, Yiguang Zhu, Guangtao Zhang, Changsheng Zhang

Publikováno v: Science China Chemistry. 64:1736-1742

Tiacumicin B (also known as fidaxomicin or difimicin) is a marketed 18-membered macrolide antibiotic for the treatment of Clostridium difficile infections. Tiacumicin B is structurally characterized with two chlorine atoms substituted on the aromatic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8302f3bf72b444f3b9583455d84ebf32
https://doi.org/10.1007/s11426-021-1072-6

Final Demonstration of the Co-Identity of Lipiarmycin A3 and Tiacumicin B (Fidaxomicin) through Single Crystal X-ray Analysis

Autor: Stefano Serra, Luciana Malpezzi, Angelo Bedeschi, Claudio Fuganti, Piera Fonte

Publikováno v: Antibiotics, Vol 6, Iss 1, p 7 (2017)

Lipiarmycin A3 and tiacumicin B possess the same chemical structure and have been considered identical till recently, when some authors have suggested the possibility of a minor difference between the chemical structures of the two antibiotics. In th

Externí odkaz: https://doaj.org/article/ad299b55165143858a6dd331364df7a1

Tiacumicin B: An Antibiotic of Prime Importance and a Natural Product with an Inspiring Complex Structure

Autor: Emmanuel Roulland

Publikováno v: SYNTHESIS
SYNTHESIS, Georg Thieme Verlag, 2018, 50 (21), pp.4189-4200. ⟨10.1055/s-0037-1609933⟩

This short review aims at decrypting and analyzing the various strategies used for the synthesis of tiacumicin B. Natural products synthesis is a way for organic chemists to express inventiveness, intellectual dexterity, and elegance in strategy of s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae46e5da8454c6b94ed8f653072547ef
https://doi.org/10.1055/s-0037-1609933

Synthesis of a Tiacumicin B Protected Aglycone

Autor: Grégory Genta-Jouve, Jean-Marie Beau, Louis Jeanne-Julien, Guillaume S. Masson, Stéphanie Norsikian, Eloi Astier, Vincent Servajean, Emmanuel Roulland

Publikováno v: Organic Letters. 19:4006-4009

Tiacumicin B is an antibiotic endowed with the remarkable ability to interact with a new biological target, giving it an inestimable potential in the context of the ever-growing and worrisome appearance of resistances of bacteria and mycobacteria to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff93792b82de235ded29e8bcd4c08851
https://doi.org/10.1021/acs.orglett.7b01744

Final Demonstration of the Co-Identity of Lipiarmycin A3 and Tiacumicin B (Fidaxomicin) through Single Crystal X-ray Analysis

Autor: Piera Fonte, Angelo Bedeschi, Luciana Malpezzi, Stefano Serra, Claudio Fuganti

Publikováno v: Antibiotics; Volume 6; Issue 1; Pages: 7
Antibiotics (Basel) 6 (2017). doi:10.3390/antibiotics6010007
info:cnr-pdr/source/autori:Serra S.; Malpezzi L.; Bedeschi A.; Fuganti C.; Fonte P./titolo:Final demonstration of the co-identity of lipiarmycin A3 and tiacumicin B(Fidaxomicin) through single crystal X-ray analysis/doi:10.3390%2Fantibiotics6010007/rivista:Antibiotics (Basel)/anno:2017/pagina_da:/pagina_a:/intervallo_pagine:/volume:6
Antibiotics
Antibiotics, Vol 6, Iss 1, p 7 (2017)

Lipiarmycin A3 and tiacumicin B possess the same chemical structure and have been considered identical till recently, when some authors have suggested the possibility of a minor difference between the chemical structures of the two antibiotics. In th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac49e9efff7f2a9be12c0d27fe6d1ba1