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pro vyhledávání: '"thymocyte development"'
Akademický článek
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Autor:
Matthew D. Taves, Jonathan D. Ashwell
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Sex steroid hormones have major effects on the thymus. Age-related increases in androgens and estrogens and pregnancy-induced increases in progestins all cause dramatic thymic atrophy. Atrophy can also be induced by treatment with exogenous sex stero
Externí odkaz:
https://doaj.org/article/e6674321f9454cbb8d82dec28a18a0e0
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
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Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
In the heart of innate and adaptive immunity lies the proper spatiotemporal development of several immune cell lineages. Multiple studies have highlighted the necessity of epigenetic and transcriptional regulation in cell lineage specification. This
Externí odkaz:
https://doaj.org/article/ceccfc445c5a476d883586b3b986e59c
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The thymus supports T-cell development via specialized microenvironments that ensure a diverse, functional and self-tolerant T-cell population. These microenvironments are classically defined as distinct cortex and medulla regions that each contain s
Externí odkaz:
https://doaj.org/article/129c4b918ffb45b0bba6ff00d37d7f6c
Autor:
Zicheng Hu, Yu Li, Annemarie Van Nieuwenhuijze, Hilary J. Selden, Angela M. Jarrett, Anna G. Sorace, Thomas E. Yankeelov, Adrian Liston, Lauren I.R. Ehrlich
Publikováno v:
Cell Reports, Vol 21, Iss 1, Pp 168-180 (2017)
Upon recognition of auto-antigens, thymocytes are negatively selected or diverted to a regulatory T cell (Treg) fate. CCR7 is required for negative selection of auto-reactive thymocytes in the thymic medulla. Here, we describe an unanticipated contri
Externí odkaz:
https://doaj.org/article/25d11f79f27b4d3fbca6883e6c7e9b5c
Autor:
Jie-Jie Geng, Juan Tang, Xiang-min Yang, Ruo Chen, Yang Zhang, Kui Zhang, Jin-Lin Miao, Zhi-Nan Chen, Ping Zhu
Publikováno v:
EBioMedicine, Vol 20, Iss C, Pp 98-108 (2017)
CD147 is highly expressed on the surface of numerous tumor cells to promote invasion and metastasis. Targeting these cells with CD147-specific antibodies has been validated as an effective approach for lung and liver cancer therapy. In the immune sys
Externí odkaz:
https://doaj.org/article/8c427bdca82243e8b4d390057b95f907
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 1996 Dec 01. 93(25), 14698-14703.
Externí odkaz:
https://www.jstor.org/stable/41149
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Proper orchestration of T lymphocyte development is critical, as T cells underlie nearly all responses of the adaptive immune system. Developing thymocytes differentiate in response to environmental cues carried from cell surface receptors to the nuc
Externí odkaz:
https://doaj.org/article/80c1e35c8d404cf1bc2c92f509ad31c5
Autor:
Umphred-Wilson, Katharine
T-cells are a central component of the adaptive immune response that promote the clearance of pathogens, immune tolerance, and tissue homeostasis. T-cell development, survival, and function are coordinated by NOTCH1, T-cell receptor (TCR), and cytoki
