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pro vyhledávání: '"thymidylate synthase directed polyepitopic peptide vaccine"'
Autor:
Marzio Vestri, Enzo Bonmassar, Gianni Gori Savellini, Marco La Placa, Angelo Aquino, Guido Francini, Giorgio Giorgi, François Lemonnier, Giuseppa Di Genova, Renato Urso, Maria Teresa Del Vecchio, Pierpaolo Correale, Chiara Terrosi, Maria Grazia Cusi
Publikováno v:
JNCI: Journal of the National Cancer Institute. 97:1437-1445
Background: Thymidylate synthase (TS), a key enzyme in DNA synthesis, is often overexpressed in cancer cells. Some chemotherapeutic agents, such as 5-fluorouracil (5-FU), act by inhibiting TS expression. We evaluated whether a novel 28-amino acid mul