Zobrazeno 1 - 10
of 53
pro vyhledávání: '"three-finger proteins"'
Autor:
Maxim M. Zaigraev, Ekaterina N. Lyukmanova, Alexander S. Paramonov, Zakhar O. Shenkarev, Anton O. Chugunov
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 11 (2022)
Ly6/uPAR proteins regulate many essential functions in the nervous and immune systems and epithelium. Most of these proteins contain single β-structural LU domains with three protruding loops and are glycosylphosphatidylinositol (GPI)-anchored to a
Externí odkaz:
https://doaj.org/article/2e52464b0b17425188fd318ee0cadc56
Autor:
Alexander S. Paramonov, Mikhail A. Shulepko, Alexey M. Makhonin, Maxim L. Bychkov, Dmitrii S. Kulbatskii, Andrey M. Chernikov, Mikhail Yu. Myshkin, Sergey V. Shabelnikov, Zakhar O. Shenkarev, Mikhail P. Kirpichnikov, Ekaterina N. Lyukmanova
Publikováno v:
Marine Drugs, Vol 20, Iss 8, p 503 (2022)
Three-finger proteins (TFPs) are small proteins with characteristic three-finger β-structural fold stabilized by the system of conserved disulfide bonds. These proteins have been found in organisms from different taxonomic groups and perform various
Externí odkaz:
https://doaj.org/article/c9dc58cc334d4852948d18e54962e1f7
Autor:
Elena V. Kryukova, Natalia S. Egorova, Denis S. Kudryavtsev, Dmitry S. Lebedev, Ekaterina N. Spirova, Maxim N. Zhmak, Aleksandra I. Garifulina, Igor E. Kasheverov, Yuri N. Utkin, Victor I. Tsetlin
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
The proteins of the Ly6 family have a three-finger folding as snake venom α-neurotoxins, targeting nicotinic acetylcholine receptors (nAChRs), and some of them, like mammalian secreted Ly6/uPAR protein (SLURP1) and membrane-attached Ly-6/neurotoxin
Externí odkaz:
https://doaj.org/article/c252f7f81ab54688bc3755c40d784318
Autor:
Konstantin S. Mineev, Elena V. Kryukova, Igor E. Kasheverov, Natalia S. Egorova, Maxim N. Zhmak, Igor A. Ivanov, Dmitry A. Senko, Alexey V. Feofanov, Anastasia A. Ignatova, Alexander S. Arseniev, Yuri N. Utkin, Victor I. Tsetlin
Publikováno v:
Biomolecules, Vol 11, Iss 1, p 1 (2020)
Lynx1, membrane-bound protein co-localized with the nicotinic acetylcholine receptors (nAChRs) and regulates their function, is a three-finger protein (TFP) made of three β-structural loops, similarly to snake venom α-neurotoxin TFPs. Since the cen
Externí odkaz:
https://doaj.org/article/ccbabfaa96ce4d369ab37c67735df925
Autor:
Alexander S. Paramonov, Milita V. Kocharovskaya, Andrey V. Tsarev, Dmitrii S. Kulbatskii, Eugene V. Loktyushov, Mikhail A. Shulepko, Mikhail P. Kirpichnikov, Ekaterina N. Lyukmanova, Zakhar O. Shenkarev
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 19, p 7280 (2020)
Ly-6/uPAR or three-finger proteins (TFPs) contain a disulfide-stabilized β-structural core and three protruding loops (fingers). In mammals, TFPs have been found in epithelium and the nervous, endocrine, reproductive, and immune systems. Here, using
Externí odkaz:
https://doaj.org/article/9cd3524cb23c48b1918e62fa48056d1e
Autor:
Maxim Zaigraev, Anton Chugunov
1) Supplementary movies are provided asseparate movfiles. They represent 2-3μsproduction phase of molecular dynamics for six different GPI-anchored Ly6 proteins studied: Lynx1, Lynx2, Lypd6, Lypd6B, Ly6H and CD59. Water molecules, ions and non-polar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b14bfc45c56c6a2f8ba97c92ca456e0
Akademický článek
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Autor:
Bychkov, M. L., Shulepko, M. A., Vasileva, V. Y., Sudarikova, A. V., Kirpichnikov, M. P., Lyukmanova, E. N.
Publikováno v:
Acta Naturae
Although tyrosine kinase inhibitors have brought significant success in the treatment of chronic myelogenous leukemia, the search for novel molecular targets for the treatmentof this disease remains relevant. Earlier, expression of acid-sensing ion c
Akademický článek
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Autor:
Igor E. Kasheverov, Konstantin S. Mineev, Alexey V. Feofanov, Dmitry A. Senko, Maxim N. Zhmak, Victor I. Tsetlin, Alexander S. Arseniev, Natalia S. Egorova, Anastasia A. Ignatova, Yuri N. Utkin, Elena V. Kryukova, Igor Ivanov
Publikováno v:
Biomolecules
Volume 11
Issue 1
Biomolecules, Vol 11, Iss 1, p 1 (2021)
Volume 11
Issue 1
Biomolecules, Vol 11, Iss 1, p 1 (2021)
Lynx1, membrane-bound protein co-localized with the nicotinic acetylcholine receptors (nAChRs) and regulates their function, is a three-finger protein (TFP) made of three &beta
structural loops, similarly to snake venom &alpha
neurotoxin TF
structural loops, similarly to snake venom &alpha
neurotoxin TF