Výsledky vyhledávání - "thiourea derivatives"

Akademický článek

Thiourea Derivatives as Estrogen Receptor Alpha Inhibitors for Breast Cancer Therapy: An In Silico Evaluation with ADMET Prediction and Molecular Docking

Autor: Hestining Puspaweni, Bambang Tri Purwanto, Tri Widiandani, Siswandono Siswodihardjo, M. Artabah Muchlisin

Publikováno v: Borneo Journal of Pharmacy, Vol 7, Iss 3 (2024)

Breast cancer remains a significant public health concern, necessitating the discovery of novel therapeutic agents. This study investigates the potential of thiourea derivatives, specifically HU, HTMX, and BMPTU compounds, as estrogen receptor alpha

Externí odkaz: https://doaj.org/article/555c54d9d9ef4c04aebc812363efa75a

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Akademický článek

Antioxidant, antibacterial, enzyme inhibition and fluorescence characteristics of unsymmetrical thiourea derivatives

Autor: Faizan Ur Rahman, Abdul Bari Shah, Mian Muhammad, Ezzat khan, Farid S. Ataya, Gaber El-Saber Batiha

Publikováno v: Heliyon, Vol 10, Iss 10, Pp e31563- (2024)

A series of six unsymmetrical thiourea derivatives, namely 1-cyclohexyl-3-(pyridin-2-yl) thiourea (1), 1-cyclohexyl-3-(3-methylpyridin-2-yl)thiourea (2), 1-cyclohexyl-3-(2,4-dimethylphenyl) thiourea (3), 1-(4-chlorophenyl)-3-cyclohexylthiourea (4), 1

Externí odkaz: https://doaj.org/article/548ab30de67a4176b2234366ba4985e5

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Akademický článek

Synthesis and in vitro activity tests of N-benzoyl-N’-phenylthiourea derivatives as macrophage migration inhibitory factor

Autor: Dini Kesuma, Galih S. Putra, Tegar A. Yuniarta, Farida Suhud, I G.A. Sumartha, Sawitri Boengas, Melanny I. Sulistyowaty, Tjie Kok

Publikováno v: Journal of Pharmacy & Pharmacognosy Research, Vol 11, Iss 5, Pp 902-925 (2023)

Context: The COVID-19 pandemic in 2020 resulted in widespread mortalities due to cytokine storms in the affected patients. Macrophage migration inhibitory factor (MIF) is one of the most interesting targets in developing anti-COVID-19 drugs. Some thi

Externí odkaz: https://doaj.org/article/8c4cb8af05da49d6881fa808f0cf2395

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Akademický článek

Synthesis, Computational Study, and In Vitro α-Glucosidase Inhibitory Action of Thiourea Derivatives Based on 3-Aminopyridin-2(1H)-Ones

Autor: Zarina Shulgau, Irina Palamarchuk, Shynggys Sergazy, Assel Urazbayeva, Alexander Gulyayev, Yerlan Ramankulov, Ivan Kulakov

Publikováno v: Molecules, Vol 29, Iss 15, p 3627 (2024)

Reactions with allyl-, acetyl-, and phenylisothiocyanate have been studied on the basis of 3-amino-4,6-dimethylpyridine-2(1H)-one, 3-amino-4-phenylpyridine-2-one, and 3-amino-4-(thiophene-2-yl)pyridine-2(1H)-one (benzoyl-)isothiocyanates, and the cor

Externí odkaz: https://doaj.org/article/764c14239883419f9ac5d9a0fb14aa54

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Akademický článek

Preparation, characterization, antioxidant activity of 1-(2-furoyl) thiourea derivatives and study the molecular docking of them as potent inhibitors of Urease enzyme

Autor: Oday H. R. Al-Jeilawi, Abdullah Qays Oleiwi

Publikováno v: Baghdad Science Journal, Vol 20, Iss 3(Suppl.) (2023)

In this work, we synthesized thirteen compounds of 1-(2-furoyl)thiourea derivatives 1-13 by conversion of 2-furoyl chloride to 2-furoyl isothiocyanate by reacting it with potassium thiocyanate in dry acetone in a quite short reflux time then, in the

Externí odkaz: https://doaj.org/article/b1f41971cdb74bdb80c0a40e0701e805

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Akademický článek

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Akademický článek

Contribution to the Synthesis, Characterization, Separation and Quantification of New N-Acyl Thiourea Derivatives with Antimicrobial and Antioxidant Potential

Autor: Roxana Roman, Lucia Pintilie, Diana Camelia Nuță, Miron Teodor Căproiu, Florea Dumitrașcu, Irina Zarafu, Petre Ioniță, Ioana Cristina Marinaș, Luminița Măruțescu, Eleonora Kapronczai, Simona Ardelean, Carmen Limban

Publikováno v: Pharmaceutics, Vol 15, Iss 10, p 2501 (2023)

The present study aimed to synthesize, characterize, and validate a separation and quantification method of new N-acyl thiourea derivatives (1a–1o), incorporating thiazole or pyridine nucleus in the same molecule and showing antimicrobial potential

Externí odkaz: https://doaj.org/article/af1c63a5a4c0470b85a722cbd034c57c

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Akademický článek

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Akademický článek

Polyphenolics, glucosinolates and isothiocyanates profiling of aerial parts of Nasturtium officinale (Watercress)

Autor: Sotiris Kyriakou, Kyriaki Michailidou, Tom Amery, Kyle Stewart, Paul G. Winyard, Dimitrios T. Trafalis, Rodrigo Franco, Aglaia Pappa, Mihalis I. Panayiotidis

Publikováno v: Frontiers in Plant Science, Vol 13 (2022)

Watercress (Nasturtium officinale) is a rich source of secondary metabolites with disease-preventing and/or health-promoting properties. Herein, we have utilized extraction procedures to isolate fractions of polyphenols, glucosinolates and isothiocya

Externí odkaz: https://doaj.org/article/bc058b1b57d64b9e85f7fad606de1873

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