Sodium-glucose cotransporter 2 inhibitors attenuate vascular calcification by suppressing endoplasmic reticulum protein thioredoxin domain containing 5 dependent osteogenic reprogramming

Autor: Shaofa Wu, Xiaolin Luo, Yang Chen, Zelan Wang, Xi Liu, Ning Sun, Junyong Zhao, Wenjian Luo, Jiawen Zhang, Xiaoyong Tong, Lan Huang, Chuan Liu, Zhexue Qin

Publikováno v: Redox Biology, Vol 73, Iss , Pp 103183- (2024)

Aims: Vascular calcification is strongly linked to the development of major adverse cardiovascular events, but effective treatments are lacking. Sodium-glucose cotransporter 2 (SGLT2) inhibitors are an emerging category of oral hypoglycemic drugs tha

Externí odkaz: https://doaj.org/article/7ad92036e98041eaad59dcffc14e70d7

Thioredoxin Domain Containing 5 Suppression Elicits Serum Amyloid A-Containing High-Density Lipoproteins

Autor: Javier Sánchez-Marco, Roberto Martínez-Beamonte, Alicia De Diego, Tania Herrero-Continente, Cristina Barranquero, Carmen Arnal, Joaquín Surra, María A. Navarro, Jesús Osada

Publikováno v: Biomedicines, Vol 10, Iss 3, p 709 (2022)

Thioredoxin domain containing 5 (TXNDC5) is a protein disulfide isomerase involved in several diseases related to oxidative stress, energy metabolism and cellular inflammation. In a previous manuscript, a negative association between fatty liver deve

Externí odkaz: https://doaj.org/article/9b6b829917614855befc9c931295db84

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TXNDC5, a newly discovered disulfide isomerase with a key role in cell physiology and pathology

Autor: Cristina Sánchez-de-Diego, Alberto Pradilla-Dieste, Elena Horna-Terrón, Jesús Osada

Publikováno v: Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 15, Iss 12, Pp 23501-23518 (2014)

Thioredoxin domain-containing 5 (TXNDC5) is a member of the protein disulfide isomerase family, acting as a chaperone of endoplasmic reticulum under not fully characterized conditions As a result, TXNDC5 interacts with many cell proteins, contributin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::150b381efdc4088b5dc7b8235e95ee85
http://zaguan.unizar.es/record/57814