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Selective disruption of mitochondrial thiol redox state in cells and in vivo

Autor: Booty, Lee M, Gawel, Justyna M, Cvetko, Filip, Caldwell, Stuart T, Hall, Andrew R, Mulvey, John F, James, Andrew M, Hinchy, Elizabeth C, Prime, Tracy A, Arndt, Sabine, Beninca, Cristiane, Bright, Thomas P, Clatworthy, Menna R, Ferdinand, John R, Prag, Hiran A, Logan, Angela, Prudent, Julien, Krieg, Thomas, Hartley, Richard C, Murphy, Michael P

Mitochondrial glutathione (GSH) and thioredoxin (Trx) systems function independently of the rest of the cell. While maintenance of mitochondrial thiol redox state is thought vital for cell survival, this was not testable due to the difficulty of mani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6611183cf2117977bcae5a2b48f7b87
https://eprints.gla.ac.uk/174223/1/174223.pdf

Selective Disruption of Mitochondrial Thiol Redox State in Cells and In Vivo

Autor: Michael P. Murphy, Andrew M. James, Thomas P. Bright, Andrew R. Hall, Angela Logan, Hiran A. Prag, Elizabeth C. Hinchy, Lee M. Booty, Cristiane Benincá, Julien Prudent, Tracy A. Prime, Menna R. Clatworthy, John F. Mulvey, Justyna M. Gawel, Thomas Krieg, Filip Cvetko, Stuart T. Caldwell, John R. Ferdinand, Richard C. Hartley, Sabine Arndt

Publikováno v: Cell Chemical Biology

Summary Mitochondrial glutathione (GSH) and thioredoxin (Trx) systems function independently of the rest of the cell. While maintenance of mitochondrial thiol redox state is thought vital for cell survival, this was not testable due to the difficulty

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::772ef8216288d46a55421863accf4539
https://doi.org/10.1016/j.chembiol.2018.12.002

Mitochondrial and cytosolic thiol redox state are not detectably altered in isolated human NADH:ubiquinone oxidoreductase deficiency

Autor: Sjoerd Verkaart, Sjenet E. van Emst-de Vries, Werner J.H. Koopman, Peter H.G.M. Willems, Lambertus W.P.J. van den Heuvel, Julia Cheek, Jan A.M. Smeitink

Publikováno v: Biochimica et Biophysica Acta. Molecular Basis of Disease, 1772, 1041-51
Biochimica et Biophysica Acta. Molecular Basis of Disease, 1772, 9, pp. 1041-51

Contains fulltext : 52541.pdf (Publisher’s version ) (Closed access) Isolated complex I deficiency is the most common enzymatic defect of the oxidative phosphorylation (OXPHOS) system, causing a wide range of clinical phenotypes. We reported before

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77a2bb114044ad2bea9228bf6bf63fdb
https://doi.org/10.1016/j.bbadis.2007.05.004