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Akademický článek

Development of effective anti-inflammatory drug candidates among novel thiazolopyridines

Autor: T. I. Chaban, V. S. Matiychuk, V. V. Ogurtsov, I. G. Chaban, I. A. Nektegayev

Publikováno v: The Ukrainian Biochemical Journal, Vol 92, Iss 2, Pp 132-139 (2020)

In an effort to develop novel anti-inflammatory agents, a series of thiazolo[4,5-b]pyridines were synthesized and modified at the N3 position. The structures of the obtained compounds were confirmed by 1H NMR spectroscopy and elemental analysis. The

Externí odkaz: https://doaj.org/article/242d7b3868fa42f2835fa3987cd0e259

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Akademický článek

Synthesis of some new thiazolo[4,5-b]pyridin-2-ones and research of their anti-inflammatory activity

Autor: T. I. Chaban

Publikováno v: Фармацевтичний журнал, Vol 4, Iss 4, Pp 52-60 (2019)

In modern theoretical and clinical medicine inflammation problem remains one of the main.Deregulation of inflammatory processes leads to specific pathologies.There is a significant amount of drugs used to treat inflammation. But all of them have vary

Externí odkaz: https://doaj.org/article/439df6ec1a044367b63ff1b67462145f

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Akademický článek

Synthesis of some new N3 substituted 5-hydroxy-7-methyl-3H-thiazolo[4,5-b]pyridin-2-ones as potential biologically active compounds

Autor: T. I. Chaban, V. V. Ohurtsov, V. S. Matiichuk, O. V. Honcharenko, I. H. Chaban

Publikováno v: Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, Vol 12, Iss 2, Pp 129-134 (2019)

Condensed bicyclic systems with thiazolidine core being annulated to pyridine one occupy prominent place in medicinal chemistry because of their broad spectrum of pharmacological activities. So, the synthesis of new N3 substitutes thiazolo[4,5-b]pyri

Externí odkaz: https://doaj.org/article/38c595cee4e84b48abcfbeb18b70aa47

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Akademický článek

Synthesis of novel thiazole, pyranothiazole, thiazolo[4,5-b]pyridines and thiazolo[5′,4′:5,6]pyrano[2,3-d]pyrimidine derivatives and incorporating isoindoline-1,3-dione group

Autor: Mona A. Hosny, Yasser H. Zaki, Wafaa A. Mokbel, Abdou O. Abdelhamid

Publikováno v: BMC Chemistry, Vol 13, Iss 1, Pp 1-10 (2019)

Abstract Background Thiazole is a core structural motif presents in a wide range of natural products. Thiazole derivatives also have a wide range of medicinal and biological properties. Results The reaction of hydrazonoyl halides with 2-(1-(4-(1,3-di

Externí odkaz: https://doaj.org/article/32e8712f52244798a1a64f4965897482

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Akademický článek

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Akademický článek

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Anti-inflammatory properties of some novel thiazolo[4,5-b]pyridin-2-ones

Autor: Olexandra Komarytsya, Ihor Nektegaev, Vasyl S. Matiychuk, Iryna Myrko, T. I. Chaban, I. G. Chaban, V. V. Ogurtsov

Publikováno v: Pharmacia 67(3): 121-127

Synthesis of novel N3 and C5 substituted thiazolo[4,5-b]pyridin-2-ones was carried out on the basis of [3+3]-cyclocodensation, acylation and alkylation reactions. The structures of the obtained compounds were confirmed by 1H NMR spectroscopy, and ele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33d346523255d6b9b13fd78a3d2ec63a
https://doi.org/10.3897/pharmacia.67.e38969

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