Preclinical Studies in Anti-Trypanosomatidae Drug Development

Autor: Cintya Perdomo, Elena Aguilera, Ileana Corvo, Paula Faral-Tello, Elva Serna, Carlos Robello, Shane R. Wilkinson, Gloria Yaluff, Guzmán Alvarez

Publikováno v: Pharmaceuticals, Vol 14, Iss 7, p 644 (2021)

The trypanosomatid parasites Trypanosoma brucei, Trypanosoma cruzi and Leishmania are the causative agents of human African trypanosomiasis, Chagas Disease and Leishmaniasis, respectively. These infections primarily affect poor, rural communities in

Externí odkaz: https://doaj.org/article/412137f8cd824fe4af8561229996da07

Multi-Anti-Parasitic Activity of Arylidene Ketones and Thiazolidene Hydrazines against Trypanosoma cruzi and Leishmania spp

Autor: Guzmán Álvarez, Gonzalo Aparicio, Celeste Vega, Mercedes González, Cintya Perdomo, Hugo Cerecetto, Flavio R. Zolessi, Miriam Rolón, Cathia Coronel, Elena Aguilera, Ruy Pérez-Montfort, Javier Varela, Antonieta Rojas de Arias, Nallely Cabrera

Publikováno v: Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules; Volume 22; Issue 5; Pages: 709
COLIBRI
Universidad de la República
instacron:Universidad de la República

A series of fifty arylideneketones and thiazolidenehydrazines was evaluated against Leishmania infantum and Leishmania braziliensis. Furthermore, new simplified thiazolidenehydrazine derivatives were evaluated against Trypanosoma cruzi. The cytotoxic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c1828e71d1bfe8a6262a1267ad36831
https://doi.org/10.3390/molecules22050709