NSC19723, a Thiacetazone-Like Benzaldehyde Thiosemicarbazone Improves the Efficacy of TB Drugs In Vitro and In Vivo

Autor: Padam Singh, Srishti Rawat, Ashish Kumar Agrahari, Manisha Singh, Saurabh Chugh, Sudagar Gurcha, Albel Singh, Katherine Abrahams, Gurdyal S. Besra, Shailendra Asthana, Diwan S. Rawat, Ramandeep Singh

Publikováno v: Microbiology Spectrum, Vol 10, Iss 6 (2022)

ABSTRACT The complexity and duration of tuberculosis (TB) treatment contributes to the emergence of drug resistant tuberculosis (DR-TB) and drug-associated side effects. Alternate chemotherapeutic agents are needed to shorten the time and improve eff

Externí odkaz: https://doaj.org/article/4c455146b10e4a6782f523375f037d3a

Mechanistic and Structural Insights Into the Unique TetR-Dependent Regulation of a Drug Efflux Pump in Mycobacterium abscessus

Autor: Matthias Richard, Ana Victoria Gutiérrez, Albertus J. Viljoen, Eric Ghigo, Mickael Blaise, Laurent Kremer

Publikováno v: Frontiers in Microbiology, Vol 9 (2018)

Mycobacterium abscessus is an emerging human pathogen causing severe pulmonary infections and is refractory to standard antibiotherapy, yet few drug resistance mechanisms have been reported in this organism. Recently, mutations in MAB_4384 leading to

Externí odkaz: https://doaj.org/article/da17605a50224ad5bcd94f62cd76c0e8

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A Coumarin-Based Analogue of Thiacetazone as Dual Covalent Inhibitor and Potential Fluorescent Label of HadA in Mycobacterium tuberculosis

Autor: Antonio Peixoto, Monika Záhorszká, Jana Korduláková, Mathieu Danel, Fernanda Goncalves, Elodie Vega, Asma Farjallah, Maria Rosalia Pasca, Mary Jackson, Giulia Degiacomi, Laurent R. Chiarelli, Cendrine Seguin, Martin Forbak, Christian Lherbet, Stefan Chassaing, Chantal Carayon, Souhir Abid, Marco Fumagalli, Anna E. Grzegorzewicz

Publikováno v: ACS Infectious Diseases
ACS Infectious Diseases, American Chemical Society, 2021, 7 (3), pp.552-565. ⟨10.1021/acsinfecdis.0c00325⟩
ACS Infectious Diseases, 2021, 7 (3), pp.552-565. ⟨10.1021/acsinfecdis.0c00325⟩

International audience; A novel coumarin-based molecule, designed as a fluorescent surrogate of a thiacetazone-derived antitubercular agent, was quickly and easily synthesized from readily available starting materials. This small molecule, coined Cou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a5b5cd98cba63d79872ca55f29014c7
https://hal.archives-ouvertes.fr/hal-03209886/document

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