The Combined Effect of Branching and Elongation on the Bioactivity Profile of Phytocannabinoids. Part I: Thermo-TRPs

Autor: Orazio Taglialatela-Scafati, Giovanni Appendino, Rosa Maria Vitale, Diego Caprioglio, Daiana Mattoteia, Luciano De Petrocellis, Aniello Schiano Moriello, Pietro Amodeo

Publikováno v: Biomedicines 9 (2021). doi:10.3390/biomedicines9081070
info:cnr-pdr/source/autori:Mattoteia D.; Moriello A.S.; Taglialatela-Scafati O.; Amodeo P.; De Petrocellis L.; Appendino G.; Vitale R.M.; Caprioglio D./titolo:The combined effect of branching and elongation on the bioactivity profile of phytocannabinoids. Part i: Thermo-trps/doi:10.3390%2Fbiomedicines9081070/rivista:Biomedicines/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:9
Biomedicines, Vol 9, Iss 1070, p 1070 (2021)
Biomedicines
Volume 9
Issue 8

The affinity of cannabinoids for their CB1 and CB2 metabotropic receptors is dramatically affected by a combination of α-branching and elongation of their alkyl substituent, a maneuver exemplified by the n-pentyl ->
α,α-dimethylheptyl (DMH)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efe7601629439ea6df17a3b143a8deb4
https://doi.org/10.3390/biomedicines9081070