Zobrazeno 1 - 9 of 9 pro vyhledávání: '"therapeutic use [Antioxidants]"'
1
Patient-reported outcomes in Friedreich's ataxia after withdrawal from idebenone
Autor: Thomas Klockgether, Arron Cook, Ewout R. Brunt, Angela Schulz, Sylvia Boesch, Suzette Heck, Paola Giunti, Ludger Schöls
Publikováno v: Acta neurologica Scandinavica, 139(6), 533-539. Wiley
Acta neurologica Scandinavica 139(6), 533-539 (2019). doi:10.1111/ane.13088
Objectives Friedreich's ataxia is the most common inherited ataxia, and pathogenesis is known to involve mitochondrial oxidative stress. Idebenone is a potent antioxidant which has already been evaluated in several clinical trials in FRDA, with repor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbc9ed3516bae68e83109ba78cedb813
https://research.rug.nl/en/publications/27a34116-4f57-4da3-b91d-a963143bfce5
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2
Real-World Clinical Experience With Idebenone in the Treatment of Leber Hereditary Optic Neuropathy
Autor: Lorena Castillo, Bettina von Livonius, John A. Lincoln, Ghislaine L. Traber, Günther Metz, Rudrani Banik, Joanna Poulton, Günther Rudolph, Andrea L Vincent, Elisabetta Scoppettuolo, Carlos Doncel, Selma Matloob, Clare L. Fraser, Xavier Lloria, Stefan J. Langenegger, Joanna Jakubaszko, Francisco J. Muñoz-Negrete, Adam Zermansky, Claudia B. Catarino, Graeme C.M. Black, Magda Silva, Christopher A. Halfpenny, Nancy J. Newman, Madhura A. Tamhankar, Klara Landau, Christoph Friedburg, Prem S. Subramanian, Oskars Mikazans, Claudia Priglinger, Mariona Vidal, Thomas Klopstock, Ahmed T. Toosy, Felice Lob, Marcin Zarowski, Marcela Votruba, Gölge Acaroglu
Publikováno v: J NEURO-OPHTHALMOL
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
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r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
Journal of neuro-ophthalmology 40(4), 558-565 (2020). doi:10.1097/WNO.0000000000001023
Journal of Neuro-Ophthalmology
Supplemental Digital Content is Available in the Text. Idebenone treatment can result in both stabilization of residual visual acuity and recovery of lost vision, with a treatment duration of at least 2 years needed to maximize the probability of rec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b21861a26b020c89014bb7dcf8ef9d9e
http://fundanet.fsjd.org/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=18330
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3
International Consensus Statement on the Clinical and Therapeutic Management of Leber Hereditary Optic Neuropathy
Autor: Michele Carbonelli, Christophe Orssaud, Alfredo A. Sadun, Jan Willem R. Pott, Nancy J. Newman, Thomas Klopstock, Piero Barboni, Wolf A. Lagrèze, Valerio Carelli, Chiara La Morgia, Catherine Vignal-Clermont, Aki Kawasaki, Marcela Votruba, Irenaeus F.M. de Coo, Judith A. M. van Everdingen, Patrick Yu-Wai-Man
Publikováno v: Journal of Neuro-Ophthalmology, 37(4), 371-381. Lippincott Williams & Wilkins
Journal of neuro-ophthalmology 37(4), 371-381 (2017). doi:10.1097/WNO.0000000000000570
Journal of Neuro-Ophthalmology, 37(4), 371-381. LIPPINCOTT WILLIAMS & WILKINS
Leber hereditary optic neuropathy (LHON) is currently estimated as the most frequent mitochondrial disease (1 in 27,000-45,000). Its molecular pathogenesis and natural history is now fairly well understood. LHON also is the first mitochondrial diseas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6b6fa5ccde255598cafd68024bb8ca2
https://pure.eur.nl/en/publications/6daba418-dd48-426d-ab96-7a5816e1a923
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4
Tracking CNS and systemic sources of oxidative stress during the course of chronic neuroinflammation
Autor: Josephine Herz, Agata Mossakowski, Helena Radbruch, Josef Priller, Michael Boschmann, Markus Bock, Leonard Viohl, Jenny Gerhard, Karolin Pollok, Moritz Radbruch, Florence Pache, Carmen Infante-Duarte, Anja Mähler, Janina Behrens, Daniel Bremer, Randall L. Lindquist, Raluca Niesner, Anja E. Hauser, Markus Bardua, Martina Füchtemeier, Julian Pohlan, Judith Bellmann-Strobl, Ronja Mothes, Jan Leo Rinnenthal, Friedemann Paul, Jason M. Millward
Publikováno v: Acta neuropathologica 130(6), 799-814 (2015). doi:10.1007/s00401-015-1497-x
Acta Neuropathologica
Mossakowski, A A, Pohlan, J, Bremer, D, Lindquist, R, Millward, J M, Bock, M, Pollok, K, Mothes, R, Viohl, L, Radbruch, M, Gerhard, J, Bellmann-Strobl, J, Behrens, J, Infante-Duarte, C, Mähler, A, Boschmann, M, Rinnenthal, J L, Füchtemeier, M, Herz, J, Pache, F C, Bardua, M, Priller, J, Hauser, A E, Paul, F, Niesner, R & Radbruch, H 2015, ' Tracking CNS and systemic sources of oxidative stress during the course of chronic neuroinflammation ', Acta Neuropathologica, vol. 130, no. 6, pp. 799-814 . https://doi.org/10.1007/s00401-015-1497-x
The functional dynamics and cellular sources of oxidative stress are central to understanding MS pathogenesis but remain elusive, due to the lack of appropriate detection methods. Here we employ NAD(P)H fluorescence lifetime imaging to detect functio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2959d06d699d7087efdfe9b712adf23a
https://pub.dzne.de/record/138235
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5
Leber's hereditary optic neuropathy (LHON/11778) with myoclonus: report of two cases
Autor: A. Baruzzi, G. L. Mancardi, Maria Lucia Valentino, Fabio Bandini, Stefano Meletti, Federica Provini, Pasquale Montagna, Valerio Carelli, Roberto Vetrugno, Rocco Liguori
Publikováno v: Journal of Neurology, Neurosurgery & Psychiatry. 71:813-816
The previously unrecognised association of myoclonus in two patients with LHON with the 11778/ND4 pathogenic mutation is described. EEG failed to disclose epileptic figures, and a back averaging study suggested that myoclonus was cortical in origin i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a474ab03b1805aefcb0900ee6a3cb3d6
https://doi.org/10.1136/jnnp.71.6.813
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6
Cognitive Enhancement Therapy for Alzheimerʼs Disease
Autor: Patrizia Mecocci, Lucilla Parnetti, Umberto Senin
Publikováno v: Drugs. 53:752-768
Although at present there is no definitive treatment or cure for Alzheimer's disease, different pharmacological strategies are being actively investigated. At present, cholinergic therapy and nootropics and some neuronotrophic agents represent the av
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b5adcbb37c6e54a1f4a0bd8362ea209
https://doi.org/10.2165/00003495-199753050-00003
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7
Pyrrolidine dithiocarbamate modulates HSP70, iNOS, and apoptosis during hemorrhagic shock resuscitation in rats
Autor: Antonella Trombetta, Paolo Cotogni, Olivero G, Roberto Bini
The aim of this study is to evaluate whether hemorrhage and resuscitation affect liver, intestinal, and renal expressions of heat shock protein 70 (HSP70), inducible nitric oxide synthase (iNOS), and apoptosis indexes (TUNEL, caspase-3 activation) an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10cee40621350d6f56eeb4ee05db53c8
http://hdl.handle.net/2318/137511
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9
Oxidative stress in kidney transplantation causes, consequences, and potential treatment
Autor: Nafar, M., Sahraei, Z., Salamzadeh, J., Shiva Samavat, Vaziri, N. D.
Publikováno v: Scopus-Elsevier
Nafar, Mohsen; Sahraei, Zahra; Salamzadeh, Jamshid; Samavat, Shiva; & Vaziri, Nosartolah D. (2011). Oxidative stress in kidney transplantation: causes, consequences, and potential treatment.. Iranian journal of kidney diseases, 5(6), 357-372. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/9523996q
Oxidative stress is a major mediator of adverse outcomes throughout the course of transplantation. Transplanted kidneys are prone to oxidative stress-mediated injury by pre-transplant and post-transplant conditions that cause reperfusion injury or im
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2e9b87ceb24e999bc5a72fee6a92d7a8
http://www.scopus.com/inward/record.url?eid=2-s2.0-80755172641&partnerID=MN8TOARS
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