Zobrazeno 1 - 2
of 2
pro vyhledávání: '"therapeutic use, Amyloid Precursor Protein Secretases"'
Publikováno v:
Current opinion in neurobiology 72, 101-110 (2022). doi:10.1016/j.conb.2021.09.003
Secretases are a group of proteases that are major drug targets considered for the prevention and treatment of Alzheimer's disease (AD). Secretases do not only process the AD-linked neuronal amyloid precursor protein (APP) but also the triggering rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::401e2110e947041283c0732a413a05a0
https://pub.dzne.de/record/163268
https://pub.dzne.de/record/163268
Autor:
Bénédicte Oulès, Patrizia Paterlini-Bréchot, Dolores Del Prete, Mounia Chami, Inger Lauritzen, Barbara Greco, Xuexin Zhang, Frédéric Checler, Sébastien Moreno, Mohamed Trebak, Jean Sevalle, Fabio Benfenati
Publikováno v:
The Journal of Neuroscience. 32:11820-11834
In Alzheimer disease (AD), the perturbation of the endoplasmic reticulum (ER) calcium (Ca2+) homeostasis has been linked to presenilins, the catalytic core in γ-secretase complexes cleaving the amyloid precursor protein (APP), thereby generating amy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b0c0f6ea578d7ddc16857385cd179e1
https://doi.org/10.1523/jneurosci.0875-12.2012
https://doi.org/10.1523/jneurosci.0875-12.2012
