Zobrazeno 1 - 10
of 2 175
pro vyhledávání: '"therapeutic proteins"'
Autor:
Robin E. Walsh, Angela Nix, Chloé Ackaert, Aurélie Mazy, Jana Schockaert, Sofie Pattyn, Laurent Malherbe
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
T-cell dependent antibody responses to biotherapeutics remain a challenge to the optimal clinical application of biotherapeutics because of their capacity to impair drug efficacy and their potential to cause safety issues. To minimize this clinical i
Externí odkaz:
https://doaj.org/article/187dcf06803947fba4abb18ce530283f
Publikováno v:
Биопрепараты: Профилактика, диагностика, лечение, Vol 23, Iss 4, Pp 480-498 (2023)
Scientific relevance. The clinical effects and the expiration of patents for original (reference) biotechnological medicines based on monoclonal antibodies (mAbs) stimulated the development of biosimilar mAbs. The quality profile of a biosimilar mAb
Externí odkaz:
https://doaj.org/article/a238d050a1dd47959698a4419c4b9c0f
Autor:
Dariusz Abramczyk, Maria del Carmen Sanchez Olmos, Adan Andres Ramirez Rojas, Daniel Schindler, Daniel Robertson, Stephen McColm, Adele L. Marston, Paul N. Barlow
Publikováno v:
Microbial Cell Factories, Vol 22, Iss 1, Pp 1-19 (2023)
Abstract Background Komagataella phaffii (Pichia pastoris) is a methylotrophic commercially important non-conventional species of yeast that grows in a fermentor to exceptionally high densities on simple media and secretes recombinant proteins effici
Externí odkaz:
https://doaj.org/article/d96f7342d724424bbcf9697fae49fd08
Autor:
Sarfaraz K. Niazi, Matthias Magoola
Publikováno v:
Biologics, Vol 3, Iss 4, Pp 355-379 (2023)
Recombinant technology has been around for nearly three quarters of a century and has revolutionized protein therapy. However, the cost of developing recombinant therapeutic proteins and the manufacturing infrastructure keeps their cost unaffordable
Externí odkaz:
https://doaj.org/article/f346e5a73b1c4bf795faa2ac6bbd8f8a
Publikováno v:
Molecules, Vol 29, Iss 19, p 4626 (2024)
The field of computational protein engineering has been transformed by recent advancements in machine learning, artificial intelligence, and molecular modeling, enabling the design of proteins with unprecedented precision and functionality. Computati
Externí odkaz:
https://doaj.org/article/7458482e6c974e29b478e761a0b13adb
Autor:
Armin Sepp
Publikováno v:
Proceedings of the Estonian Academy of Sciences, Vol 72, Iss 4, Pp 371-381 (2023)
Three Pillars of Survival paradigm in the pharmaceutical drug discovery stipulates that a drug candidate is more likely to reach Phase III if it meets the following criteria: 1) it reaches the required tissue compartment, 2) engages the desired targe
Externí odkaz:
https://doaj.org/article/2439d3adbd0d480880ad7701cead604b
Autor:
Sarfaraz K. Niazi, Zamara Mariam
Publikováno v:
Biologics, Vol 3, Iss 2, Pp 72-94 (2023)
Reinventing approved therapeutic proteins for a new dose, a new formulation, a new route of administration, an improved safety profile, a new indication, or a new conjugate with a drug or a radioactive source is a creative approach to benefit from th
Externí odkaz:
https://doaj.org/article/f8fa940ca67b48cc98127d3730aac57d
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 163, Iss , Pp 114757- (2023)
The circulatory half-life of recombinant therapeutic proteins is an important pharmacokinetic attribute because it determines the dosing frequency of these drugs, translating directly to treatment cost. Thus, recombinant therapeutic glycoproteins suc
Externí odkaz:
https://doaj.org/article/a560f677b3cf4a09bd98741e1d085795
Autor:
Ilaria Porello, Francesco Cellesi
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Achieving the full potential of therapeutic proteins to access and target intracellular receptors will have enormous benefits in advancing human health and fighting disease. Existing strategies for intracellular protein delivery, such as chemical mod
Externí odkaz:
https://doaj.org/article/a6c8a89f4da64e4c96306592ac228440
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