Zobrazeno 1 - 10
of 17
pro vyhledávání: '"the Kidney Precision Medicine Project"'
Autor:
Insa M. Schmidt, Aditya L. Surapaneni, Runqi Zhao, Dhairya Upadhyay, Wan-Jin Yeo, Pascal Schlosser, Courtney Huynh, Anand Srivastava, Ragnar Palsson, Taesoo Kim, Isaac E. Stillman, Daria Barwinska, Jonathan Barasch, Michael T. Eadon, Tarek M. El-Achkar, Joel Henderson, Dennis G. Moledina, Sylvia E. Rosas, Sophie E. Claudel, Ashish Verma, Yumeng Wen, Maja Lindenmayer, Tobias B. Huber, Samir V. Parikh, John P. Shapiro, Brad H. Rovin, Ian B. Stanaway, Neha A. Sathe, Pavan K. Bhatraju, Josef Coresh, the Kidney Precision Medicine Project, Eugene P. Rhee, Morgan E. Grams, Sushrut S. Waikar
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract The kidney tubules constitute two-thirds of the cells of the kidney and account for the majority of the organ’s metabolic energy expenditure. Acute tubular injury (ATI) is observed across various types of kidney diseases and may significan
Externí odkaz:
https://doaj.org/article/41855c04b12d4c92a5497040b3021033
Autor:
Debora L. Gisch, Michelle Brennan, Blue B. Lake, Jeannine Basta, Mark S. Keller, Ricardo Melo Ferreira, Shreeram Akilesh, Reetika Ghag, Charles Lu, Ying-Hua Cheng, Kimberly S. Collins, Samir V. Parikh, Brad H. Rovin, Lynn Robbins, Lisa Stout, Kimberly Y. Conklin, Dinh Diep, Bo Zhang, Amanda Knoten, Daria Barwinska, Mahla Asghari, Angela R. Sabo, Michael J. Ferkowicz, Timothy A. Sutton, Katherine J. Kelly, Ian H. De Boer, Sylvia E. Rosas, Krzysztof Kiryluk, Jeffrey B. Hodgin, Fadhl Alakwaa, Seth Winfree, Nichole Jefferson, Aydın Türkmen, Joseph P. Gaut, Nils Gehlenborg, Carrie L. Phillips, Tarek M. El-Achkar, Pierre C. Dagher, Takashi Hato, Kun Zhang, Jonathan Himmelfarb, Matthias Kretzler, Shamim Mollah, the Kidney Precision Medicine Project (KPMP), Sanjay Jain, Michael Rauchman, Michael T. Eadon
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract There is a need to define regions of gene activation or repression that control human kidney cells in states of health, injury, and repair to understand the molecular pathogenesis of kidney disease and design therapeutic strategies. Comprehe
Externí odkaz:
https://doaj.org/article/8d81e0f3c4d54dd6b9a6681fc0df894c
Autor:
Victor Hugo Canela, William S. Bowen, Ricardo Melo Ferreira, Farooq Syed, James E. Lingeman, Angela R. Sabo, Daria Barwinska, Seth Winfree, Blue B. Lake, Ying-Hua Cheng, Joseph P. Gaut, Michael Ferkowicz, Kaice A. LaFavers, Kun Zhang, Fredric L. Coe, Elaine Worcester, the Kidney Precision Medicine Project, Sanjay Jain, Michael T. Eadon, James C. Williams, Tarek M. El-Achkar
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Kidney stone disease causes significant morbidity and increases health care utilization. In this work, we decipher the cellular and molecular niche of the human renal papilla in patients with calcium oxalate (CaOx) stone disease and healthy
Externí odkaz:
https://doaj.org/article/9079daace87a49889ca16163b6717e46
Autor:
Brendon Lutnick, David Manthey, Jan U. Becker, Brandon Ginley, Katharina Moos, Jonathan E. Zuckerman, Luis Rodrigues, Alexander J. Gallan, Laura Barisoni, Charles E. Alpers, Xiaoxin X. Wang, Komuraiah Myakala, Bryce A. Jones, Moshe Levi, Jeffrey B. Kopp, Teruhiko Yoshida, Jarcy Zee, Seung Seok Han, Sanjay Jain, Avi Z. Rosenberg, Kuang Yu. Jen, Pinaki Sarder, the Kidney Precision Medicine Project
Publikováno v:
Communications Medicine, Vol 2, Iss 1, Pp 1-15 (2022)
Lutnick et al. develop a cloud-based deep learning tool for whole slide image segmentation. The authors provide several examples of its application in renal pathology, for segmenting glomeruli, interstitial fibrosis and other features of interest.
Externí odkaz:
https://doaj.org/article/55a83f05e2a54ed1a808a7fafb19b7b9
Autor:
Tara K. Sigdel, Paul D. Piehowski, Sudeshna Roy, Juliane Liberto, Joshua R. Hansen, Adam C. Swensen, Rui Zhao, Ying Zhu, Priyanka Rashmi, Andrew Schroeder, Izabella Damm, Swastika Sur, Jinghui Luo, Yingbao Yang, Wei-Jun Qian, Minnie M. Sarwal, The Kidney Precision Medicine Project (KPMP) Consortium
Publikováno v:
Frontiers in Medicine, Vol 7 (2020)
Molecular assessments at the single cell level can accelerate biological research by providing detailed assessments of cellular organization and tissue heterogeneity in both disease and health. The human kidney has complex multi-cellular states with
Externí odkaz:
https://doaj.org/article/3732ec0f49974b1fabd73c81171d8162
Autor:
Canela, Victor Hugo, Bowen, William S., Ferreira, Ricardo Melo, Syed, Farooq, Lingeman, James E., Sabo, Angela R., Barwinska, Daria, Winfree, Seth, Lake, Blue B., Cheng, Ying-Hua, Gaut, Joseph P., Ferkowicz, Michael, LaFavers, Kaice A., Zhang, Kun, Coe, Fredric L., Worcester, Elaine, the Kidney Precision Medicine Project, Jain, Sanjay, Eadon, Michael T., Williams Jr., James C.
Publikováno v:
Nature Communications; 7/19/2023, Vol. 14 Issue 1, p1-17, 17p
Autor:
Lutnick, Brendon, Manthey, David, Becker, Jan U, Ginley, Brandon, Moos, Katharina, Zuckerman, Jonathan E, Rodrigues, Luis, Gallan, Alexander J, Barisoni, Laura, Alpers, Charles E, Wang, Xiaoxin X, Myakala, Komuraiah, Jones, Bryce A, Levi, Moshe, Kopp, Jeffrey B, Yoshida, Teruhiko, Zee, Jarcy, Han, Seung Seok, Jain, Sanjay, Rosenberg, Avi Z, Jen, Kuang Yu, Sarder, Pinaki, Kidney Precision Medicine Project
Publikováno v:
Communications medicine, vol 2, iss 1
Background Image-based machine learning tools hold great promise for clinical applications in pathology research. However, the ideal end-users of these computational tools (e.g., pathologists and biological scientists) often lack the programming expe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3532ed73d43162764b68b7a7cf7c684e
https://doi.org/10.1038/s43856-022-00138-z
https://doi.org/10.1038/s43856-022-00138-z
Autor:
Hansen, Jens, Sealfon, Rachel, Menon, Rajasree, Eadon, Michael T, Lake, Blue B, Steck, Becky, Anjani, Kavya, Parikh, Samir, Sigdel, Tara K, Zhang, Guanshi, Velickovic, Dusan, Barwinska, Daria, Alexandrov, Theodore, Dobi, Dejan, Rashmi, Priyanka, Otto, Edgar A, Rivera, Miguel, Rose, Michael P, Anderton, Christopher R, Shapiro, John P, Pamreddy, Annapurna, Winfree, Seth, Xiong, Yuguang, He, Yongqun, de Boer, Ian H, Hodgin, Jeffrey B, Barisoni, Laura, Naik, Abhijit S, Sharma, Kumar, Sarwal, Minnie M, Zhang, Kun, Himmelfarb, Jonathan, Rovin, Brad, El-Achkar, Tarek M, Laszik, Zoltan, He, John Cijiang, Dagher, Pierre C, Valerius, M Todd, Jain, Sanjay, Satlin, Lisa M, Troyanskaya, Olga G, Kretzler, Matthias, Iyengar, Ravi, Azeloglu, Evren U, Kidney Precision Medicine Project
Publikováno v:
Science advances, vol 8, iss 23
Kidney Precision Medicine Project (KPMP) is building a spatially specified human kidney tissue atlas in health and disease with single-cell resolution. Here, we describe the construction of an integrated reference map of cells, pathways, and genes us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::47af9eba269707c5ed6ceac065e21301
https://escholarship.org/uc/item/1rg1b3nt
https://escholarship.org/uc/item/1rg1b3nt
Autor:
the Kidney Precision Medicine Project, Ian H. de Boer, Kumar Sharma, Trevor J. Orchard, Tina Costacou, Janet K. Snell-Bergeon, Subramaniam Pennathur, Per-Henrik Groop, Tarunveer S. Ahluwalia, Peter Rossing, Jing Zhang, Sushrut S. Waikar, Tomas Vaisar, Insa M. Schmidt, Niina Sandholm, John Ruzinski, Sylvia E. Rosas, Robert D. Toto, John F. O’Toole, Robert G. Nelson, Viji Nair, Daniel Montemayor, Matthias Kretzler, Wenjun Ju, Andrew N. Hoofnagle, Clark M. Henderson, Carol Forsblom, Manjula Darshi, Loki Natarajan, Viktor Drel, Erkka Valo, Christine P. Limonte
Objective: Understanding mechanisms underlying rapid estimated glomerular filtration rate (eGFR) decline is important to predict and treat kidney disease in type 1 diabetes (T1D). Research Design and Methods: We performed a case-control study nested
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed338d73bcfe04947deb88b3e5e26ac
https://doi.org/10.2337/figshare.19337210.v1
https://doi.org/10.2337/figshare.19337210.v1
Autor:
Rashmi, Priyanka, Sur, Swastika, Sigdel, Tara K, Boada, Patrick, Schroeder, Andrew W, Damm, Izabella, Kretzler, Matthias, Hodgin, Jeff, Hartoularos, George, Jimmie Ye, Chun, Sarwal, Minnie M, Kidney Precision Medicine Project
Publikováno v:
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, vol 22, iss 3
Maintenance of systemic homeostasis by kidney requires the coordinated response of diverse cell types. The use of single-cell RNA sequencing (scRNAseq) for patient tissue samples remains fraught with difficulties with cell isolation, purity, and expe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::5e73c284b02ebd69ba70ee85a4704b75
https://escholarship.org/uc/item/9sn4x6sk
https://escholarship.org/uc/item/9sn4x6sk