Zobrazeno 1 - 5
of 5
pro vyhledávání: '"the CHARGE Gene-lifestyle Interactions Working Group"'
Autor:
Xiaofeng Zhu, Yihe Yang, Noah Lorincz-Comi, Gen Li, Amy R. Bentley, Paul S. de Vries, Michael Brown, Alanna C. Morrison, Charles N. Rotimi, W. James Gauderman, Dabeeru C. Rao, Hugues Aschard, the CHARGE Gene-lifestyle Interactions Working Group
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract There is a long-standing debate about the magnitude of the contribution of gene-environment interactions to phenotypic variations of complex traits owing to the low statistical power and few reported interactions to date. To address this iss
Externí odkaz:
https://doaj.org/article/66a84dd74b9247fdbe2989f4fda3077a
Autor:
Vincent Laville, Timothy Majarian, Paul S. de Vries, Amy R. Bentley, Mary F. Feitosa, Yun J. Sung, D. C. Rao, Alisa Manning, Hugues Aschard, on behalf of the CHARGE Gene-Lifestyle Interactions Working Group
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-11 (2020)
Abstract Background Models including an interaction term and performing a joint test of SNP and/or interaction effect are often used to discover Gene-Environment (GxE) interactions. When the environmental exposure is a binary variable, analyses from
Externí odkaz:
https://doaj.org/article/aecc576ad18d40848a9d0f189f9e6749
Autor:
Timothy D. Majarian, Amy R. Bentley, Vincent Laville, Michael R. Brown, Daniel I. Chasman, Paul S. de Vries, Mary F. Feitosa, Nora Franceschini, W. James Gauderman, Casey Marchek, Daniel Levy, Alanna C. Morrison, Michael Province, Dabeeru C. Rao, Karen Schwander, Yun Ju Sung, Charles N. Rotimi, Hugues Aschard, C. Charles Gu, Alisa K. Manning, on behalf of the CHARGE Gene-Lifestyle Interactions Working Group
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Though both genetic and lifestyle factors are known to influence cardiometabolic outcomes, less attention has been given to whether lifestyle exposures can alter the association between a genetic variant and these outcomes. The Cohorts for Heart and
Externí odkaz:
https://doaj.org/article/52cda5d16983458c835040c49c566491
Autor:
Laville, Vincent, Majarian, Timothy, Sung, Yun, Schwander, Karen, Feitosa, Mary, Chasman, Daniel, Bentley, Amy, Rotimi, Charles, Cupples, L., de Vries, Paul, Brown, Michael, Morrison, Alanna, Kraja, Aldi, Province, Mike, Gu, C., Gauderman, W., Working Group, The Charge Gene-Lifestyle Interactions, Rao, D., Manning, Alisa, Aschard, Hugues
Publikováno v:
European Journal of Human Genetics
European Journal of Human Genetics, 2022, 30, pp.730-739. ⟨10.1038/s41431-022-01045-6⟩
European Journal of Human Genetics, 2022, 30, pp.730-739. ⟨10.1038/s41431-022-01045-6⟩
The role and biological significance of gene-environment interactions in human traits and diseases remain poorly understood. To address these questions, the CHARGE Gene-Lifestyle Interactions Working Group conducted series of genome-wide interaction
Autor:
Bamidele O. Tayo, RJ Waken, Mario Sims, Diane M. Becker, Tõnu Esko, Yingchang Lu, Pamela J. Schreiner, Antonietta Robino, Anne U. Jackson, H. Janaka de Silva, Peter J. van der Most, Archie Campbell, Ozren Polasek, Salman M. Tajuddin, Jing Hua Zhao, Barbara V. Howard, Saima Afaq, Vilmundur Gudnason, Lynda M. Rose, Francis S. Collins, Massimiliano Cocca, Ruth J. F. Loos, Yii-Der Ida Chen, W. James Gauderman, Jaspal S. Kooner, Lawrence F. Bielak, Ulrich Broeckel, Anuradhani Kasturiratne, Melissa A. Richard, Tomohiro Katsuya, Nicola D. Kerrison, Tin Aung, Lisa de las Fuentes, Lynne E. Wagenknecht, Oscar H. Franco, Yongmei Liu, Eric Boerwinkle, Nana Matoba, Saskia P. Hagenaars, Rob M. van Dam, Tibor V. Varga, Nilesh J. Samani, Tangchun Wu, Thomas H. Mosley, Caroline Hayward, Joseph H. Lee, Frida Renström, Tamara B. Harris, Alena Stančáková, Adesola Ogunniyi, Wen Bin Wei, Lenore J. Launer, Marcus Dörr, Xiuqing Guo, Jennifer A. Smith, Terho Lehtimäki, Dan E. Arking, Fang-Chi Hsu, Karin Leander, Martin Farrall, Konstantin Strauch, Albert V. Smith, Richard S. Cooper, Chiea Chuen Khor, Changwei Li, James E. Hixson, Sami Heikkinen, David R. Weir, Pirjo Komulainen, Renée de Mutsert, Raymond Noordam, Ubaydah Nasri, Paul M. Ridker, C. Charles Gu, Tamuno Alfred, Jerome I. Rotter, Nora Franceschini, Nita G. Forouhi, Lihua Wang, Alanna C. Morrison, Jian-Min Yuan, Ching-Yu Cheng, Peter S. Braund, Paul Elliott, Gregory P. Wilson, Jianjun Liu, Xiaofeng Zhu, Markku Laakso, Christian Gieger, Yukihide Momozawa, Rainer Rettig, Carsten Oliver Schmidt, Amy R. Bentley, Wei Zhao, Ioanna Ntalla, Kenneth Rice, Yoichiro Kamatani, Andres Metspalu, Helen R. Warren, Yechiel Friedlander, Susan Redline, Kurt Lohman, Cornelia M. van Duijn, Aravinda Chakravarti, Traci M. Bartz, Sarah E. Harris, Yih Chung Tham, He Gao, Mike A. Nalls, Mathilde Boissel, Donna K. Arnett, Harold Snieder, James S. Pankow, Babatunde L. Salako, Laura J. Bierut, Tin Louie, Albertine J. Oldehinkel, Xueling Sim, Thomas Meitinger, Maris Alver, Claudia Langenberg, Stephen B. Kritchevsky, Norihiro Kato, Evangelos Evangelou, Philippe Froguel, Alexandre C. Pereira, Michael R. Brown, Karen Schwander, Charles Kooperberg, Blair H. Smith, Annette Peters, Fernando Pires Hartwig, Yanhua Zhou, Jie Yao, Alisa K. Manning, Keng-Hung Lin, Dennis O. Mook-Kanamori, Ervin R. Fox, Tuomo Rankinen, Timo A. Lakka, Charles N. Rotimi, Nicholette D. Palmer, Jiang He, Nicholas J. Wareham, Jingmin Liu, Yun Ju Sung, Cathy C. Laurie, Donald W. Bowden, Yong-Bing Xiang, Lisa R. Yanek, B. Kuhnel, Nancy L. Pedersen, Yajuan Wang, Ananda R. Wickremasinghe, Jonathan Marten, Yi-Jen Hung, Dabeeru C. Rao, Bernardo L. Horta, Joel D. Kaufman, Barry I. Freedman, Chuan Gao, Olli T. Raitakari, Reedik Mägi, Solomon K. Musani, Albert Hofman, Wanqing Wen, Heming Wang, Xiao-Ou Shu, Y Liu, Mark J. Caulfield, Meian He, Daniel I. Chasman, Carl D. Langefeld, Charumathi Sabanayagam, Bruce M. Psaty, Jasmin Divers, R. Graham Barr, Chew-Kiat Heng, Stella Aslibekyan, John M. Starr, Stefan Weiss, Anuj Goel, Tuomas O. Kilpeläinen, Terrence Forrester, Mary F. Feitosa, Jost B. Jonas, Kae-Woei Liang, Colleen M. Sitlani, Daniel Levy, Marie Loh, Qing Duan, Aldi T. Kraja, Tien Yin Wong, Myriam Fornage, Andrea R. V. R. Horimoto, Michele K. Evans, David J. Porteous, Dina Vojinovic, Hua Tang, Michael A. Province, Ching-Ti Liu, Rainer Rauramaa, William R. Scott, Cora E. Lewis, Charles B. Eaton, Sharon L.R. Kardia, Michael Boehnke, James Scott, Colin A McKenzie, Jin-Fang Chai, Woon-Puay Koh, Yucheng Jia, Claude Bouchard, Peter S. Sever, Koichi Matsuda, Najaf Amin, Ulf de Faire, Walter Palmas, André G. Uitterlinden, Thomas T. Perls, Erin B. Ware, Wayne Huey-Herng Sheu, Michiaki Kubo, Ya Xing Wang, Hugh Watkins, Steven C. Hunt, Weihua Zhang, Johanna Kuusisto, Lili Milani, Rajkumar Dorajoo, Georg Ehret, L. Adrienne Cupples, Franco Giulianini, Zoltán Kutalik, Jose E Krieger, Kevin Sandow, Bruna Gigante, Alexander P. Reiner, Preeti Gupta, Heikki A. Koistinen, Treva Rice, Patricia B. Munroe, Wen-Jane Lee, Jennifer A. Brody, Paolo Gasparini, Paul W. Franks, Yik Ying Teo, Leo-Pekka Lyytikäinen, Thomas W. Winkler, Patricia A. Peyser, Ian J. Deary, Jessica D. Faul, Sing Hui Lim, Fumihiko Takeuchi, Xu Chen, Brian E. Cade, Patrik K. E. Magnusson, John C. Chambers, Tamar Sofer, E. Shyong Tai, Candace M Kammerer, Mary K. Wojczynski, Pim van der Harst, Marzyeh Amini, Jennifer G. Robinson, Erwin P. Bottinger, Alan B. Zonderman, Benjamin Lehne, M. Waldenberger, Jeffrey R. O'Connell, Hugues Aschard, Ilaria Gandin, Kent D. Taylor, Igor Rudan, Christopher P. Nelson, John M. C. Connell, Jian'an Luan, Mickaël Canouil, Robert A. Scott, Yize Li, Marguerite R. Irvin
Publikováno v:
Hum Mol Genet
Human Molecular Genetics
Human Molecular Genetics, Oxford University Press (OUP), 2019, 28 (15), pp.2615-2633. ⟨10.1093/hmg/ddz070⟩
Human Molecular Genetics, 2019, 28 (15), pp.2615-2633. ⟨10.1093/hmg/ddz070⟩
Human Molecular Genetics, 28(15), 2615-2633. Oxford University Press
Human Molecular Genetics, 28(15), 2615-2633. OXFORD UNIV PRESS
2019, ' A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure ', Human Molecular Genetics . https://doi.org/10.1093/hmg/ddz070
Human Molecular Genetics, Vol. 28, No 15 (2019) pp. 2615-2633
Human Molecular Genetics
Human Molecular Genetics, Oxford University Press (OUP), 2019, 28 (15), pp.2615-2633. ⟨10.1093/hmg/ddz070⟩
Human Molecular Genetics, 2019, 28 (15), pp.2615-2633. ⟨10.1093/hmg/ddz070⟩
Human Molecular Genetics, 28(15), 2615-2633. Oxford University Press
Human Molecular Genetics, 28(15), 2615-2633. OXFORD UNIV PRESS
2019, ' A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure ', Human Molecular Genetics . https://doi.org/10.1093/hmg/ddz070
Human Molecular Genetics, Vol. 28, No 15 (2019) pp. 2615-2633
Elevated blood pressure (BP), a leading cause of global morbidity and mortality, is influenced by both genetic and lifestyle factors. Cigarette smoking is one such lifestyle factor. Across five ancestries, we performed a genome-wide gene–smoking in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5654ae9b91f97c8df58b8fa976a56c73
https://europepmc.org/articles/PMC6644157/
https://europepmc.org/articles/PMC6644157/