Zobrazeno 1 - 10
of 705
pro vyhledávání: '"tgfb1"'
Autor:
Wei‐Chia Tsao, Rwei‐Ling Yu, Chi‐Ting Li, Wei‐Fang Tsai, Wan‐Long Chuang, Jee‐Fu Huang, Chia‐Yen Dai, Chun‐Hsiang Tan
Publikováno v:
Kaohsiung Journal of Medical Sciences, Vol 40, Iss 9, Pp 852-861 (2024)
Abstract Recent studies have identified a correlation between chronic viral hepatitis and cognitive impairment, yet the underlying mechanisms remain unclear. This study investigated the influence of TGFB1 genetic polymorphisms on cognitive function i
Externí odkaz:
https://doaj.org/article/5a9fb174e3a84cd88519c985c6333b0f
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-24 (2024)
Abstract This study investigated the mechanism of the extracellular matrix-mimicking hydrogel-mediated TGFB1/Nrf2 signaling pathway in osteoarthritis using bone marrow mesenchymal stem cell-derived exosomes (BMSCs-Exos). A GMOCS-Exos hydrogel was syn
Externí odkaz:
https://doaj.org/article/cd6589eabbea40929bb8d959cfbb12f5
Autor:
Maria Fernanda Suarez, Tatsuo Itakura, Satyabrata Pany, Shinwu Jeong, Shravan K. Chintala, Michael B. Raizman, Steven Riesinger, Tsvetelina Lazarova, José Echenique, Horacio M. Serra, W. Daniel Stamer, M. Elizabeth Fini
Publikováno v:
Stresses, Vol 3, Iss 3, Pp 629-652 (2023)
Elevated intraocular pressure (IOP), the major risk factor for glaucoma, is caused by decreased outflow through the trabecular meshwork (TM). The pathophysiology of ocular hypertension has been linked to stress pathways, including fibrosis, calcifica
Externí odkaz:
https://doaj.org/article/d7b8cb97eb0046e480769cd972be43a1
Autor:
Anya C. Jones, Jonatan Leffler, Ingrid A. Laing, Joelene Bizzintino, Siew-Kim Khoo, Peter N. LeSouef, Peter D. Sly, Patrick G. Holt, Deborah H. Strickland, Anthony Bosco
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-12 (2023)
Abstract Asthma exacerbations in children are associated with respiratory viral infection and atopy, resulting in systemic immune activation and infiltration of immune cells into the airways. The gene networks driving the immune activation and subseq
Externí odkaz:
https://doaj.org/article/18ac5eb4bd4b4257b8ceb0da32978369
Publikováno v:
Renal Failure, Vol 45, Iss 1 (2023)
AbstractObjective The aim of our study was to identify key biomarkers of glomeruli in focal glomerulosclerosis (FSGS) and analyze their relationship with the infiltration of immune cells.Methods The expression profiles (GSE108109 and GSE200828) were
Externí odkaz:
https://doaj.org/article/38ba99ee81004b10b28300f8bfa7677f
Autor:
Zhi‐Wen Chen, Feng‐Ping Kang, Cheng‐Ke Xie, Cheng‐Yu Liao, Ge Li, Yong‐Ding Wu, Hong‐Yi Lin, Shun‐Cang Zhu, Jian‐Fei Hu, Cai‐Feng Lin, Yi Huang, Yi‐Feng Tian, Long Huang, Zu‐Wei Wang, Shi Chen
Publikováno v:
Advanced Science, Vol 10, Iss 32, Pp n/a-n/a (2023)
Abstract Intrahepatic cholangiocarcinoma (ICC) is characterized by its dense fibrotic microenvironment and highly malignant nature, which are associated with chemotherapy resistance and very poor prognosis. Although circRNAs have emerged as important
Externí odkaz:
https://doaj.org/article/8ad815b4b506453cb69e0257fa85c7f0
Autor:
Arantxa Martínez-Férriz, Carolina Gandía, José Miguel Pardo-Sánchez, Alihamze Fathinajafabadi, Alejandro Ferrando, Rosa Farràs
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Background Eukaryotic Initiation Factor 5A (eIF-5A), an essential translation factor, is post-translationally activated by the polyamine spermidine. Two human genes encode eIF-5A, being eIF5-A1 constitutively expressed whereas eIF5-A2 is fre
Externí odkaz:
https://doaj.org/article/e20c17cf88e24b858a7e403110413a7f
Autor:
Dilys Leung, Zoe K. Price, Noor A. Lokman, Wanqi Wang, Lizamarie Goonetilleke, Elif Kadife, Martin K. Oehler, Carmela Ricciardelli, George Kannourakis, Nuzhat Ahmed
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-23 (2022)
Abstract Background Epithelial ovarian cancer is the most lethal gynaecological cancer worldwide. Chemotherapy resistance represents a significant clinical challenge and is the main reason for poor ovarian cancer prognosis. We identified novel expres
Externí odkaz:
https://doaj.org/article/0bf982e54f6942ba87713c8c2e280ab1
Autor:
Aline Rodrigues Costa, Cristine Dieter, Luís Henrique Canani, Taís Silveira Assmann, Daisy Crispim
Publikováno v:
Genetics and Molecular Biology, Vol 46, Iss 3 (2023)
Abstract The transforming growth factor beta 1 (TGFB1) is a pro-inflammatory cytokine that plays a key role in the mechanisms of angiogenesis and breakdown of the blood-retina barrier, which are implicated in the pathogenesis of diabetic retinopathy
Externí odkaz:
https://doaj.org/article/10992ff6659e45d68b94d2d72e9d3eb5
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