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Akademický článek

The role of coagulation hemostasis for development of early-onset preeclampsia in low-risk patients

Autor: M. G. Nikolaeva, K. V. Shchekleina, A. P. Momot, V. Yu. Terekhina, E. V. Grigorieva

Publikováno v: Акушерство, гинекология и репродукция, Vol 16, Iss 4, Pp 391-400 (2022)

Aim: to determine a role of specific parameters of coagulation hemostasis for development of severe early-onset preeclampsia (еPE) in low-risk patients.Materials and Methods. A single-center prospective study included 40 patients with a physiologica

Externí odkaz: https://doaj.org/article/27b2fbd62d2849f6b2193dad8d3a583b

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Akademický článek

Single‐cell RNA sequencing reveals a mechanism underlying the susceptibility of the left atrial appendage to intracardiac thrombogenesis during atrial fibrillation

Autor: Jie Yang, Hu Tan, Mengjia Sun, Renzheng Chen, Zhao Jian, Yuanbin Song, Jihang Zhang, Shizhu Bian, Bo Zhang, Yi Zhang, Xubin Gao, Zhen Chen, Boji Wu, Xiaowei Ye, Hailin Lv, Zhen Liu, Lan Huang

Publikováno v: Clinical and Translational Medicine, Vol 13, Iss 6, Pp n/a-n/a (2023)

Abstract Background Atrial fibrillation (AF) is associated with an increased risk of thrombosis of the left atrial appendage (LAA). However, the molecular mechanisms underlying this site‐specificity remain poorly understood. Here, we present a comp

Externí odkaz: https://doaj.org/article/886312f4883741bea507372d9e79f9f5

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Akademický článek

Endothelial-dependent S-Sulfhydration of tissue factor pathway inhibitor regulates blood coagulation

Autor: Janina Wittig, Maria-Kyriaki Drekolia, Anastasia Kyselova, Fredy Delgado Lagos, Magdalena L. Bochenek, Jiong Hu, Katrin Schäfer, Ingrid Fleming, Sofia-Iris Bibli

Publikováno v: Redox Biology, Vol 62, Iss , Pp 102694- (2023)

Tissue factor pathway inhibitor (TFPI) is an important regulator of coagulation and a link between inflammation and thrombosis. Here we investigated whether endothelial cell-driven oxidative post-translational modifications could have an impact on TF

Externí odkaz: https://doaj.org/article/c64a64aa8ebc45a1b6f1d0275628ebc7

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Akademický článek

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Akademický článek

Concizumab as a Subcutaneous Prophylactic Treatment Option for Patients with Hemophilia A or B: A Review of the Evidence and Patient’s Perspectives

Autor: Pasca S

Publikováno v: Journal of Blood Medicine, Vol Volume 13, Pp 191-199 (2022)

Samantha Pasca1,2 1Medicine Department (DIMED) – Padua University Hospital, Padua, Italy; 2Biomedical Sciences Department (DSB) - Padua University Hospital, Padua, ItalyCorrespondence: Samantha Pasca, Medicine Department (DIMED) – Padua Universit

Externí odkaz: https://doaj.org/article/cdebe52c757c454180dbc1d6c6222b63

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Akademický článek

Structural and functional properties of the Kunitz-type and C-terminal domains of Amblyomin-X supporting its antitumor activity

Autor: K. L. P. Morais, L. Ciccone, E. Stura, M. P. Alvarez-Flores, G. Mourier, M. Vanden Driessche, J. M. Sciani, A. Iqbal, S. P. Kalil, G. J. Pereira, R. Marques-Porto, P. Cunegundes, L. Juliano, D. Servent, A. M. Chudzinski-Tavassi

Publikováno v: Frontiers in Molecular Biosciences, Vol 10 (2023)

Amblyomin-X is a Kunitz-type FXa inhibitor identified through the transcriptome analysis of the salivary gland from Amblyomma sculptum tick. This protein consists of two domains of equivalent size, triggers apoptosis in different tumor cell lines, an

Externí odkaz: https://doaj.org/article/1dda03cd9dbb4ede84e2fbe8555f9a69

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Akademický článek

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Akademický článek

A Kunitz-type inhibitor from tick salivary glands: A promising novel antitumor drug candidate

Autor: Aline R. M. Lobba, Miryam Paola Alvarez-Flores, Melissa Regina Fessel, Marcus Vinicius Buri, Douglas S. Oliveira, Renata N. Gomes, Priscila S. Cunegundes, Carlos DeOcesano-Pereira, Victor D. Cinel, Ana M. Chudzinski-Tavassi

Publikováno v: Frontiers in Molecular Biosciences, Vol 9 (2022)

Salivary glands are vital structures responsible for successful tick feeding. The saliva of ticks contains numerous active molecules that participate in several physiological processes. A Kunitz-type factor Xa (FXa) inhibitor, similar to the tissue f

Externí odkaz: https://doaj.org/article/555884386be24d9ea33c4470bba4c752

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Akademický článek

Expression analysis of tissue factor pathway inhibitors TFPI-1 and TFPI-2 in Paralichthys olivaceus and antibacterial and anticancer activity of derived peptides

Autor: Guanghua Wang, Bing Xie, Yanli Su, Qinqin Gu, Dongfang Hao, Hongmei Liu, Changbiao Wang, Yonghua Hu, Min Zhang

Publikováno v: Veterinary Research, Vol 52, Iss 1, Pp 1-13 (2021)

Abstract Tissue factor pathway inhibitors (TFPI), including TFPI-1 and TFPI-2, are Kunitz-type serine protease inhibitors that mainly inhibit the blood coagulation induced by tissue factors. Previous reports on teleost proved TFPI play important role

Externí odkaz: https://doaj.org/article/ab1b3096d53748e9a5f8e8b647ce0ea1

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