Zobrazeno 1 - 10
of 15
pro vyhledávání: '"tessa holyoake"'
Autor:
Anne-Louise Latif, Ashley Newcombe, Sha Li, Kathryn Gilroy, Neil A. Robertson, Xue Lei, Helen J. S. Stewart, John Cole, Maria Terradas Terradas, Loveena Rishi, Lynn McGarry, Claire McKeeve, Claire Reid, William Clark, Joana Campos, Kristina Kirschner, Andrew Davis, Jonathan Lopez, Jun-ichi Sakamaki, Jennifer P. Morton, Kevin M. Ryan, Stephen W. G. Tait, Sheela A. Abraham, Tessa Holyoake, Brian Higgins, Xu Huang, Karen Blyth, Mhairi Copland, Timothy J. T. Chevassut, Karen Keeshan, Peter D. Adams
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
MDM2 and BET inhibitors have shown efficacy in AML treatment. Here, the authors show that the two compounds can synergize through both p53 protein stabilization and inhibition of BRD4-mediated repression of p53 target genes.
Externí odkaz:
https://doaj.org/article/4058dbf2924543a399c2f17c8fd2a6ad
Autor:
Richard A. Van Etten, Steffen Koschmieder, Francois Delhommeau, Danilo Perrotti, Tessa Holyoake, Animesh Pardanani, Ruben Mesa, Tony Green, Amr R. Ibrahim, Tariq Mughal, Robert Peter Gale, John Goldman
Publikováno v:
Haematologica, Vol 96, Iss 4 (2011)
This review focuses on topical issues in the biology and treatment of the myeloproliferative neoplasms (MPNs). Studies in transgenic mice suggest that BCR-ABL1 reduces the fraction of self-renewing ‘leukemic’ stem cells in the bone marrow but tha
Externí odkaz:
https://doaj.org/article/34f649a2185b47bd9d3339711691443b
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 9, p e1000503 (2009)
Imatinib mesylate induces complete cytogenetic responses in patients with chronic myeloid leukemia (CML), yet many patients have detectable BCR-ABL transcripts in peripheral blood even after prolonged therapy. Bone marrow studies have shown that this
Externí odkaz:
https://doaj.org/article/a3a728b03e7e499091e3e993abeb518a
Autor:
Eduardo Gómez-Castañeda, Simon Rogers, Chinmay Munje, Joana Bittencourt-Silvestre, Mhairi Copland, David Vetrie, Tessa Holyoake, Lisa Hopcroft, Heather Jørgensen
Publikováno v:
Cancers; Volume 14; Issue 21; Pages: 5253
2AbstractTyrosine kinase inhibitors (TKI) have revolutionised the treatment of CML. However, TKI do not eliminate the leukaemia stem cells (LSC), which can reinitiate the disease. Thus, finding new therapeutic targets in CML LSC is key to finding a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::877d404047d2eb40e6eb52dd441b3bb7
https://pubmed.ncbi.nlm.nih.gov/36358672
https://pubmed.ncbi.nlm.nih.gov/36358672
Autor:
Sha Li, Anne-Louise Latif, Ashley Newcombe, Kathryn Gilrory, Neil Robertson, Darren Finlay, Xue Lei, Helen Stewart, Karina Barbosa, John Cole, Maria Terradas Terradas, Loveena Rishi, Lynn McGarry, Claire McKeeve, Claire Reid, William Clark, Joana Campos, Kristina Kirschner, Jonathan Lopez, Jun-Ichi Sakamaki, Jennifer Morton, Kevin Ryan, Stephen Tait, Sheela Abraham, Tessa Holyoake, Brian Higgins, Xu Huang, Mhairi Copland, Tim Chevassut, Ani Deshpande, Karen Keeshan, Peter Adams
Publikováno v:
Experimental Hematology. 88:S70
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b3862009165d9bdb156e4fd5d23c563
https://doi.org/10.1016/j.exphem.2020.09.115
https://doi.org/10.1016/j.exphem.2020.09.115
Publikováno v:
Europe PubMed Central
Chronic myeloid leukemia (CML) is characterized by an increased proliferative activity of the leukemic progenitors that produce an elevated number of mature granulocytes. Nevertheless, cell cycle-active agents, even in very high doses, are alone unab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cac9a09489673ad9bec49bd50626c192
https://doi.org/10.1182/blood.v94.6.2056.418k13_2056_2064
https://doi.org/10.1182/blood.v94.6.2056.418k13_2056_2064
Publikováno v:
Pakistan journal of pharmaceutical sciences. 24(3)
The LC-ESI-MS was developed and validated for the analysis of imatinib in plasma and bone marrow samples using deuterated imatinib (D(8)-IM) as an internal standard. The biological samples were extracted using Strata-X-C SPE cartridges and separated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5e8f2d60aa55beed29b08a81260e711f
https://pubmed.ncbi.nlm.nih.gov/21715261
https://pubmed.ncbi.nlm.nih.gov/21715261
Autor:
Dj, Dunlop, Eg, Wright, Lorimore S, Gj, Graham, tessa holyoake, Dj, Kerr, Sd, Wolpe, Ib, Pragnell
Publikováno v:
Europe PubMed Central
The proliferative status of the stem cell compartment is thought to be controlled by both positive and negative regulators of proliferation. These regulators have obvious clinical potential in manipulating the integrity and proliferative status of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bfb0337647a2cdc158d85c5e5deb5b5
https://doi.org/10.1182/blood.v79.9.2221.bloodjournal7992221
https://doi.org/10.1182/blood.v79.9.2221.bloodjournal7992221
Autor:
P Lewis, White, Richard, Barton, Malcolm, Guiver, Christopher J, Linton, Steve, Wilson, Melvyn, Smith, Beatriz L, Gomez, Michael J, Carr, Patrick T, Kimmitt, Shila, Seaton, Kumar, Rajakumar, Tessa, Holyoake, Chris C, Kibbler, Elizabeth, Johnson, Richard P, Hobson, Brian, Jones, Rosemary A, Barnes
Publikováno v:
The Journal of molecular diagnostics : JMD. 8(3)
The limitations of classical diagnostic methods for invasive fungal infections (IFIs) have led to the development of molecular techniques to aid in the detection of IFIs. Despite good published performance, interlaboratory reproduction of these assay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a9f693311211bfcf294c7a461b49b3e7
https://pubmed.ncbi.nlm.nih.gov/16825500
https://pubmed.ncbi.nlm.nih.gov/16825500
Autor:
Tessa Holyoake, Jorge Cortes
Publikováno v:
Cancer. 98:1776-1777
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31b217c642d33a1ad87a647a50e0d48c
https://doi.org/10.1002/cncr.11715
https://doi.org/10.1002/cncr.11715