Zobrazeno 1 - 10
of 117
pro vyhledávání: '"ten-eleven translocation 2"'
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundInterstitial lung disease (ILD) is a rare clinical presentation of primary myelofibrosis (PMF).Case presentationWe report a case of ILD as the main manifestation on admission. A 58-year-old man was diagnosed with PMF owing to worsening anem
Externí odkaz:
https://doaj.org/article/53e1a58b4ef64a9c96377a13fc354b2a
Autor:
Woo Seok Song, Meiling Xia
Publikováno v:
Stress and Brain, Vol 3, Iss 4, Pp 147-158 (2023)
The ten-eleven translocation 2 (Tet2) protein, a member of the Tet family, acts as an α-ketoglutarate- and Fe2+-dependent dioxygenase that catalyzes the iterative oxidation of 5-methylcytosine. Tet2 is widely recognized for its involvement in divers
Externí odkaz:
https://doaj.org/article/35181cc438504103a6939ba8952b3743
Publikováno v:
eJHaem, Vol 4, Iss 3, Pp 738-744 (2023)
Abstract Background: DNA hypermethylation and instability due to inactivation mutations in Ten–eleven translocation 2 (TET2) is a key biomarker of hematological malignancies. This study aims at characterizing two intronic noncanonical splice‐site
Externí odkaz:
https://doaj.org/article/3e649e4777dd423db42321de4ec6726c
Publikováno v:
Annals of Hepatology, Vol 29, Iss 2, Pp 101183- (2024)
Introduction and Objectives: MicroRNA-326 is abnormally expressed in autoimmune diseases, but its roles in autoimmune hepatitis (AIH) are unknown. In this study, we aimed to investigate the effect of miR-326 on AIH and the underlying mechanism. Mater
Externí odkaz:
https://doaj.org/article/650f111a9c954ce7b16045f55c1d194e
Akademický článek
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Publikováno v:
Experimental Hematology & Oncology, Vol 10, Iss 1, Pp 1-11 (2021)
Abstract Objective To explore the correlation of mutation landscape with clinical outcomes in patients with peripheral T-cell lymphoma (PTCL). Methods We retrospectively analyzed the clinicopathological and prognosis data of 53 patients with PTCL fro
Externí odkaz:
https://doaj.org/article/e31f77130117414995de492aa5e6b640
Publikováno v:
Archives of Biological Sciences, Vol 73, Iss 2, Pp 303-313 (2021)
Proliferation, migration, and the phenotypic switch of vascular smooth muscle cells (VSMCs) play an important role in vascular remodeling induced by hypertension. Astragaloside IV (AS-IV), the active ingredient of Astragalus membranaceus, has been sh
Externí odkaz:
https://doaj.org/article/8b81dd77205a428999a3aaee61ad8f19
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Type 2 diabetes condition mediated vascular smooth muscle cell (VSMCs) dysfunction. However, the mechanism of VSMCs dysfunction in diabetic patients needs further elucidation. VSMCs are an important component of the vascular wall, participate in the
Externí odkaz:
https://doaj.org/article/d30c00976b234ccdae0e962b0b9703be
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
The epigenetic modifications, such as DNA methylation and histone acetylation, play a critical role in the pathogenesis of Parkinson's disease (PD). However, the relationship between DNA methylation and histone acetylation in PD is not fully understo
Externí odkaz:
https://doaj.org/article/3c65201087364f40b9fc75fc8b84c0df
Autor:
Ting Li, Ting Fang, Linxin Xu, Xiangyang Liu, Xiaoyu Li, Mei Xue, Xiaochen Yu, Bei Sun, Liming Chen
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
Background: Metabolic associated fatty liver disease (MAFLD), characterized by hepatic lipid accumulation and fatty degeneration, is intertwined with obesity and type 2 diabetes mellitus (T2DM). Empagliflozin is a sodium-glucose cotransporter-2 inhib
Externí odkaz:
https://doaj.org/article/1939e010d8d4431e91178eeb06efca9c