Engineered SPIONs functionalized with endothelin a receptor antagonist ameliorate liver fibrosis by inhibiting hepatic stellate cell activation

Autor: ten Hove, Marit, Smyris, Andreas, Booijink, Richell, Wachsmuth, Lydia, Hansen, Uwe, Alic, Lejla, Faber, Cornelius, Hӧltke, Carsten, Bansal, Ruchi

Publikováno v: In Bioactive Materials September 2024 39:406-426

WED-441 - A novel orally available type IV autotaxin inhibitor, IOA-289, ameliorates steatosis and fibrosis in a preclinical model of non-alcoholic steatohepatitis

Autor: ten Hove, Marit, Di Conza, Giusy, Niewola, Karolina, Deken, Marcel, van der Veen, Lars, Bansal, Ruchi

Publikováno v: In Journal of Hepatology June 2023 78 Supplement 1:S761-S762

The hepatic lipidome: From basic science to clinical translation.

Autor: Ten Hove M; Translational Liver Research, Department of Medical Cell BioPhysics, Faculty of Science and Technology, Technical Medical Center, University of Twente, Enschede 7500 AE, the Netherlands., Pater L; Translational Liver Research, Department of Medical Cell BioPhysics, Faculty of Science and Technology, Technical Medical Center, University of Twente, Enschede 7500 AE, the Netherlands., Storm G; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht 3584 CG, the Netherlands; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 119074 Singapore, Singapore., Weiskirchen S; Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH University Hospital Aachen, Aachen 52074, Germany., Weiskirchen R; Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH University Hospital Aachen, Aachen 52074, Germany., Lammers T; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht 3584 CG, the Netherlands; Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging, Uniklinik RWTH Aachen and Helmholtz Institute for Biomedical Engineering, Faculty of Medicine, RWTH Aachen University, Aachen 52074, Germany., Bansal R; Translational Liver Research, Department of Medical Cell BioPhysics, Faculty of Science and Technology, Technical Medical Center, University of Twente, Enschede 7500 AE, the Netherlands. Electronic address: r.bansal@utwente.nl.

Publikováno v: Advanced drug delivery reviews [Adv Drug Deliv Rev] 2020; Vol. 159, pp. 180-197. Date of Electronic Publication: 2020 Jun 30.