Zobrazeno 1 - 10
of 273
pro vyhledávání: '"ten Hoopen, P."'
Autor:
Alvin Wei Tian Ng, Dylan Peter McClurg, Ben Wesley, Shahriar A. Zamani, Emily Black, Ahmad Miremadi, Olivier Giger, Rogier ten Hoopen, Ginny Devonshire, Aisling M. Redmond, Nicola Grehan, Sriganesh Jammula, Adrienn Blasko, Xiaodun Li, Samuel Aparicio, Simon Tavaré, Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium, Karol Nowicki-Osuch, Rebecca C. Fitzgerald
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Esophageal adenocarcinoma is a prominent example of cancer characterized by frequent amplifications in oncogenes. However, the mechanisms leading to amplicons that involve breakage-fusion-bridge cycles and extrachromosomal DNA are poorly und
Externí odkaz:
https://doaj.org/article/70172e9506b8433ca7874eabf4b5a777
Autor:
Doesjka A. Hagenaar, Karen G. C. B. Bindels-de Heus, Maud M. van Gils, Louise van den Berg, Leontine W. ten Hoopen, Philine Affourtit, Johan J. M. Pel, Koen F. M. Joosten, Manon H. J. Hillegers, Henriëtte A. Moll, Marie-Claire Y. de Wit, Gwen C. Dieleman, Sabine E. Mous
Publikováno v:
Journal of Neurodevelopmental Disorders, Vol 16, Iss 1, Pp 1-20 (2024)
Abstract Background Angelman syndrome (AS) is a rare neurodevelopmental disorder characterized by severe intellectual disability, little to no expressive speech, visual and motor problems, emotional/behavioral challenges, and a tendency towards hyper
Externí odkaz:
https://doaj.org/article/856668e8b5f44749a3e85e1460045e02
Autor:
A. R. Müller, B. den Hollander, P. M. van de Ven, K. C. B. Roes, L. Geertjens, H. Bruining, C. D. M. van Karnebeek, F. E. Jansen, M. C. Y. de Wit, L. W. ten Hoopen, A. B. Rietman, B. Dierckx, F. A. Wijburg, E. Boot, M. M. G. Brands, A. M. van Eeghen
Publikováno v:
BMC Psychiatry, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract Background Many rare genetic neurodevelopmental disorders (RGNDs) are characterized by intellectual disability (ID), severe cognitive and behavioral impairments, potentially diagnosed as a comorbid autism spectrum disorder or attention-defic
Externí odkaz:
https://doaj.org/article/4f74098acbcb4b4a96235bd2a74ca971
Autor:
Annelieke R. Müller, Michiel A. J. Luijten, Lotte Haverman, Wendela L. de Ranitz-Greven, Peter Janssens, André B. Rietman, Leontine W. ten Hoopen, Laura C. G. de Graaff, Marie-Claire de Wit, Anna C. Jansen, Tanjala Gipson, Jamie K. Capal, Petrus J. de Vries, Agnies M. van Eeghen
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Background Tuberous sclerosis complex (TSC) is a rare and complex genetic disorder, associated with tumor growth in various organ systems, epilepsy, and a range of neuropsychiatric manifestations including intellectual disability. With impro
Externí odkaz:
https://doaj.org/article/3108e33f8bbe45ac9d13900319306ed9
Autor:
Alvin Wei Tian Ng, Dylan Peter McClurg, Ben Wesley, Shahriar A. Zamani, Emily Black, Ahmad Miremadi, Olivier Giger, Rogier ten Hoopen, Ginny Devonshire, Aisling M. Redmond, Nicola Grehan, Sriganesh Jammula, Adrienn Blasko, Xiaodun Li, Samuel Aparicio, Simon Tavaré, Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium, Karol Nowicki-Osuch, Rebecca C. Fitzgerald
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/e131446b35e94c42af2e34ae89cd9a66
Sustained year-round oceanographic measurements from Rothera Research Station, Antarctica, 1997–2017
Autor:
Hugh Venables, Michael P. Meredith, Katharine R. Hendry, Petra ten Hoopen, Helen Peat, Alice Chapman, Jennifer Beaumont, Rayner Piper, Andrew J. Miller, Paul Mann, Helen Rossetti, Ali Massey, Terri Souster, Simon Reeves, Mairi Fenton, Sabrina Heiser, Sam Pountney, Sarah Reed, Zoë Waring, Marlon Clark, Emma Bolton, Ryan Mathews, Hollie London, Alice Clement, Emma Stuart, Aurelia Reichardt, Mark Brandon, Melanie Leng, Carol Arrowsmith, Amber Annett, Sian F. Henley, Andrew Clarke
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-13 (2023)
Abstract Oceanographic changes adjacent to Antarctica have global climatic and ecological impacts. However, this is the most challenging place in the world to obtain marine data due to its remoteness and inhospitable nature, especially in winter. Her
Externí odkaz:
https://doaj.org/article/6d750b2382ba4cd3b73f060a60deeb2f
Autor:
Nathalie van Dijk, Fabiënne Vliegen, Angelique Ham, Wim de Jongh, Freek Jan Berkhout, Jeroen Blankevoort, Rankie ten Hoopen, Jan Bollen, Walther van Mook
Publikováno v:
Frontiers in Dementia, Vol 2 (2023)
BackgroundOrgan donation after euthanasia (ODE) has been performed over 100 times in the Netherlands, primarily involving patients suffering from a neurodegenerative or psychiatric disease. In recent years, the number of euthanasia cases related to d
Externí odkaz:
https://doaj.org/article/be1c01c42b374a1fa585c980bd2e9325
Publikováno v:
Earth System Science Data, Vol 15, Pp 211-224 (2023)
We present a database from substantial collections of macronutrient data made on 20 oceanographic cruises, primarily from around the island of South Georgia and the Scotia Sea. This sector of the Southern Ocean was studied comprehensively during the
Externí odkaz:
https://doaj.org/article/1ff14d7b7ca04b7f9e5e1d607e552cfc
Autor:
Praneeth R. Kuninty, Karin Binnemars-Postma, Ahmed Jarray, Kunal P. Pednekar, Marcel A. Heinrich, Helen J. Pijffers, Hetty ten Hoopen, Gert Storm, Peter van Hoogevest, Wouter K. den Otter, Jai Prakash
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Tumor-associated macrophages are mostly pro-tumorigenic, due to their re-programming by the tumor microenvironment. Here authors show that nanoliposomes, incorporating phospholipids with a flipping-tail chain, are engulfed specifically by intratumora
Externí odkaz:
https://doaj.org/article/c7139cc6942449fc878247554c64ac93
Autor:
Philip S. Robinson, Laura E. Thomas, Federico Abascal, Hyunchul Jung, Luke M. R. Harvey, Hannah D. West, Sigurgeir Olafsson, Bernard C. H. Lee, Tim H. H. Coorens, Henry Lee-Six, Laura Butlin, Nicola Lander, Rebekah Truscott, Mathijs A. Sanders, Stefanie V. Lensing, Simon J. A. Buczacki, Rogier ten Hoopen, Nicholas Coleman, Roxanne Brunton-Sim, Simon Rushbrook, Kourosh Saeb-Parsy, Fiona Lalloo, Peter J. Campbell, Iñigo Martincorena, Julian R. Sampson, Michael R. Stratton
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Inherited mutations in MUTYH have been shown to predispose patients to colorectal cancers. Here, the authors show that MUTYH mutations lead to an increased somatic base substitution mutation rate in normal intestinal epithelial cells, which is the li
Externí odkaz:
https://doaj.org/article/c14b563faf084d9f9abf9b953d1b62bf