Zobrazeno 1 - 10
of 260
pro vyhledávání: '"temporal identity"'
Publikováno v:
Neural Development, Vol 17, Iss 1, Pp 1-14 (2022)
Abstract Background Neural progenitors produce diverse cells in a stereotyped birth order, but can specify each cell type for only a limited duration. In the Drosophila embryo, neuroblasts (neural progenitors) specify multiple, distinct neurons by se
Externí odkaz:
https://doaj.org/article/26794c2f5bf14e018f06e977f155116a
Publikováno v:
Neural Development, Vol 15, Iss 1, Pp 1-14 (2020)
Abstract Background Spatial patterning specifies neural progenitor identity, with further diversity generated by temporal patterning within individual progenitor lineages. In vertebrates, these mechanisms generate “cardinal classes” of neurons th
Externí odkaz:
https://doaj.org/article/620360937e3c4045b32ea8997d1b9343
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 4, Pp 1393-1401 (2020)
During Drosophila melanogaster metamorphosis, arrested immature neurons born during larval development differentiate into their functional adult form. This differentiation coincides with the downregulation of two zinc-finger transcription factors, Ch
Externí odkaz:
https://doaj.org/article/8472a001d4e840788fbde26e0c9d7f3e
Autor:
Brandon Mark, Sen-Lin Lai, Aref Arzan Zarin, Laurina Manning, Heather Q Pollington, Ashok Litwin-Kumar, Albert Cardona, James W Truman, Chris Q Doe
Publikováno v:
eLife, Vol 10 (2021)
The mechanisms specifying neuronal diversity are well characterized, yet it remains unclear how or if these mechanisms regulate neural circuit assembly. To address this, we mapped the developmental origin of 160 interneurons from seven bilateral neur
Externí odkaz:
https://doaj.org/article/7c643a9dcfe149a986542c2158e46cb8
Autor:
Dennis, Daniel J., Wilkinson, Grey, Li, Saiqun, Dixit, Rajiv, Adnani, Lata, Balakrishnan, Anjali, Han, Sisu, Kovach, Christopher, Gruenig, Nicole, Kurrasch, Deborah M., Dyck, Richard H., Schuurmans, Carol
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2017 Jun . 114(25), E4934-E4943.
Externí odkaz:
https://www.jstor.org/stable/26484948
Akademický článek
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Publikováno v:
eLife, Vol 8 (2019)
How circuits assemble starting from stem cells is a fundamental question in developmental neurobiology. We test the hypothesis that, in neuronal stem cells, temporal transcription factors predictably control neuronal terminal features and circuit ass
Externí odkaz:
https://doaj.org/article/e163295adacc43b8bf1d3ee8b7f58e42
Publikováno v:
eLife, Vol 8 (2019)
Neural progenitors undergo temporal patterning to generate diverse neurons in a chronological order. This process is well-studied in the developing Drosophila brain and conserved in mammals. During larval stages, intermediate neural progenitors (INPs
Externí odkaz:
https://doaj.org/article/18ef728abe594f30859d6a106e43ef31
Publikováno v:
eLife, Vol 8 (2019)
Spatial and temporal cues are required to specify neuronal diversity, but how these cues are integrated in neural progenitors remains unknown. Drosophila progenitors (neuroblasts) are a good model: they are individually identifiable with relevant spa
Externí odkaz:
https://doaj.org/article/4cc6e2a3411d450da3c59d861fb65ed7
Akademický článek
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