Telomere length analysis in amyotrophic lateral sclerosis using large-scale whole genome sequence data

Autor: Ahmad Al Khleifat, Alfredo Iacoangeli, Ashley R. Jones, Joke J. F. A. van Vugt, Matthieu Moisse, Aleksey Shatunov, Ramona A. J. Zwamborn, Rick A. A. van der Spek, Johnathan Cooper-Knock, Simon Topp, Wouter van Rheenen, Brendan Kenna, Kristel R. Van Eijk, Kevin Kenna, Ross Byrne, Victoria López, Sarah Opie-Martin, Atay Vural, Yolanda Campos, Markus Weber, Bradley Smith, Isabella Fogh, Vincenzo Silani, Karen E. Morrison, Richard Dobson, Michael A. van Es, Russell L. McLaughlin, Patrick Vourc’h, Adriano Chio, Philippe Corcia, Mamede de Carvalho, Marc Gotkine, Monica Povedano Panades, Jesus S. Mora, Pamela J. Shaw, John E. Landers, Jonathan D. Glass, Christopher E. Shaw, Nazli Basak, Orla Hardiman, Wim Robberecht, Philip Van Damme, Leonard H. van den Berg, Jan H. Veldink, Ammar Al-Chalabi

Publikováno v: Frontiers in Cellular Neuroscience, Vol 16 (2022)

BackgroundAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the loss of upper and lower motor neurons, leading to progressive weakness of voluntary muscles, with death following from neuromuscular respiratory failure

Externí odkaz: https://doaj.org/article/61449fea63ae4dd59fb2a82311667ab2

Prognostic Association of TERC, TERT Gene Polymorphism, and Leukocyte Telomere Length in Acute Heart Failure: A Prospective Study

Autor: Yanxiu Li, Iokfai Cheang, Zhongwen Zhang, Wenming Yao, Yanli Zhou, Haifeng Zhang, Yun Liu, Xiangrong Zuo, Xinli Li, Quan Cao

Publikováno v: Frontiers in Endocrinology, Vol 12 (2021)

BackgroundTelomere length and telomerase are associated in development of cardiovascular diseases. Study aims to investigate the associations of TERC and TERT gene polymorphism and leukocyte telomere length (LTL) in the prognosis of acute heart failu

Externí odkaz: https://doaj.org/article/8e794b6af68a4348a7d49a979c6ddc98

Hot and dry conditions predict shorter nestling telomeres in an endangered songbird: Implications for population persistence

Autor: Justin R. Eastwood, Tim Connallon, Kaspar Delhey, Michelle L. Hall, Niki Teunissen, Sjouke A. Kingma, Ariana M. La Porte, Simon Verhulst, Anne Peters

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 119(25)
Proceedings of the National Academy of Sciences of the United States of America, 119(25):e2122944119. NATL ACAD SCIENCES
Proceedings of the National Academy of Sciences of the United States of America 119 (2022) 25

Climate warming is increasingly exposing wildlife to sublethal high temperatures, which may lead to chronic impacts and reduced fitness. Telomere length (TL) may link heat exposure to fitness, particularly at early-life stages, because developing org

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb2771e678016af2c83494061746eaf6
https://pubmed.ncbi.nlm.nih.gov/35696588

Association Between Leukocyte Telomere Length and the Risk of Incident Atrial Fibrillation: The Framingham Heart Study

Autor: Laila Staerk, Biqi Wang, Kathryn L. Lunetta, Robert H. Helm, Darae Ko, Jason A. Sherer, Patrick T. Ellinor, Steven A. Lubitz, David D. McManus, Ramachandran S. Vasan, Emelia J. Benjamin, Ludovic Trinquart

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 11 (2017)

BackgroundAdvancing age is a prominent risk factor for atrial fibrillation (AF). Shorter telomere length is a biomarker of biological aging, but the link between shorter telomere length and increased risk of AF remains unclear. We examined the associ

Externí odkaz: https://doaj.org/article/7875d8df25ab49919e85dce38f53ff06

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