Zobrazeno 1 - 10
of 473
pro vyhledávání: '"telomerase inhibitor"'
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Background Telomerase, by safeguarding damaged telomeres and bolstering DNA damage repair, has the capacity to heighten the radioresistance of tumour cells. Thus, in turn, can compromise the efficacy of radiotherapy (RT) and radioimmunothera
Externí odkaz:
https://doaj.org/article/56775fe79e2c4b5487b985d449e20b9f
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Maintaining the structural integrity of genomic chromosomal DNA is an essential role of cellular life and requires two important biological mechanisms: the DNA damage response (DDR) mechanism and telomere protection mechanism at chromosome ends. Beca
Externí odkaz:
https://doaj.org/article/1a159fc4f47f4bf0bb23db8b5f6cac01
Autor:
Khadijeh Dizaji Asl, Ali Rafat, Ali Akbar Movassaghpour, Hojjatollah Nozad Charoudeh, Hamid Tayefi Nasrabadi
Publikováno v:
Advanced Pharmaceutical Bulletin, Vol 13, Iss 1, Pp 170-175 (2023)
Purpose: Acute myeloid leukemia (AML) is known to be an invasive and highly lethal hematological malignancy in adults and children. Resistance to the present treatments, including radiotherapy and chemotherapy with their side effects and telomere len
Externí odkaz:
https://doaj.org/article/d8dff0a3344846d081c885d878f82c2a
Akademický článek
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Publikováno v:
Translational Oncology, Vol 27, Iss , Pp 101569- (2023)
Quercetin is a natural flavonoid with well-established anti-proliferative activities against a variety of cancers. Telomerase inhibitor MST-312 also exhibits anti-proliferative effect on various cancer cells independent of its effect on telomere shor
Externí odkaz:
https://doaj.org/article/8a339a222a2842279c912b1d79e5fdda
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Shunyu Zhang, Jinxia Li, Liang Yan, Yue You, Feng Zhao, Jixing Cheng, Limin Yang, Yanqi Sun, Qingchao Chang, Ru Liu, Yunhui Li
Publikováno v:
Nanomaterials, Vol 13, Iss 11, p 1779 (2023)
Telomerase is constitutively overexpressed in the majority of human cancers and telomerase inhibition provides a promising broad-spectrum anticancer therapeutic strategy. BIBR 1532 is a well-known synthetic telomerase inhibitor that blocks the enzyma
Externí odkaz:
https://doaj.org/article/8694519294bc44f38a465ce34fba8b36
Publikováno v:
Chinese Journal of Lung Cancer, Vol 24, Iss 1, Pp 25-30 (2021)
Lung cancer is one of the malignant tumors with high incidence rate and high mortality worldwide. Telomere and telomerase are closely related to the occurrence and development of lung cancer. Although telomerase may not be the direct cause of carcino
Externí odkaz:
https://doaj.org/article/d2831931cb0d45d99cafb6e1fa0b4d2b
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 345-361 (2021)
Based on previous studies, 66 2-phenyl-4H-chromone derivatives containing amide and 1,3,4-oxadiazole moieties were prepared as potential telomerase inhibitors. The results showed most of the title compounds exhibited significantly inhibitory activity
Externí odkaz:
https://doaj.org/article/7b4619047aa046dda50e031ee8716e87
Autor:
Ali Zineddine Boumehira, Bronywn Kirby, Marla Trindade, Hocine Hacène, Enoch Y. Park, Hesham A. El Enshasy
Publikováno v:
Fermentation, Vol 8, Iss 10, p 473 (2022)
A Gram-positive strain, ADR1, was isolated from soil collected from the Algerian Sahara Desert. The ethyl acetate extract of the fermentation broth showed cytotoxic activity against the PANC-1 cell line (37.1 ± 1.3% viability when applied at a conce
Externí odkaz:
https://doaj.org/article/079f25df96f140d8972635cbac14e134