Zobrazeno 1 - 10
of 618
pro vyhledávání: '"tau aggregation"'
Autor:
Yoshiyuki Soeda, Emi Hayashi, Naoko Nakatani, Shinsuke Ishigaki, Yuta Takaichi, Taro Tachibana, Yuichi Riku, James K. Chambers, Riki Koike, Moniruzzaman Mohammad, Akihiko Takashima
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Prior to the formation of amyloid fibrils, the pathological hallmark in tau-related neurodegenerative disease, tau monomers aggregate into a diverse range of oligomers. Granular tau oligomers, consisting of approximately 40 tau protein molec
Externí odkaz:
https://doaj.org/article/bca48ca3cae24e98acfdf58791c53295
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 6, Pp 1221-1232 (2024)
Alzheimer’s disease is characterized by two major neuropathological hallmarks—the extracellular β-amyloid plaques and intracellular neurofibrillary tangles consisting of aggregated and hyperphosphorylated Tau protein. Recent studies suggest that
Externí odkaz:
https://doaj.org/article/6fef2a4444084826a17ec59fd7d262a7
Publikováno v:
Biophysics and Physicobiology, Vol 21 (2024)
Single-molecule imaging in living cells is an effective tool for elucidating the mechanisms of cellular phenomena at the molecular level. However, the analysis was not designed for throughput and requires high expertise, preventing it from reaching l
Externí odkaz:
https://doaj.org/article/4f36b47bbfa94f189a9e162e4fc815f1
Autor:
Lenka Hromadkova, Chae Kim, Tracy Haldiman, Lihua Peng, Xiongwei Zhu, Mark Cohen, Rohan de Silva, Jiri G. Safar
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-25 (2023)
Abstract Objectives Although accumulation of misfolded tau species has been shown to predict cognitive decline in patients with Alzheimer’s disease (AD) and other tauopathies but with the remarkable diversity of clinical manifestations, neuropathol
Externí odkaz:
https://doaj.org/article/1bf5a23fc0af4be6baee96c7e0437b3f
Autor:
Saurabh Awasthi, Liviana Mummolo, Yuanjie Li, Louise Bryan, Peter Niraj Nirmalraj, Sandor Balog, Jerry Yang, Michael Mayer
Publikováno v:
CHIMIA, Vol 77, Iss 12 (2023)
Externí odkaz:
https://doaj.org/article/cf77e4d62b684aa592f685dbac71b7bb
Autor:
Zhina ZHANG, Zhuoran WANG, Mingxuan YANG, Yanli ZHANG, Guowei LIU, Shu FANG, Qiang SU, Qiao NIU, Junhong GUO
Publikováno v:
环境与职业医学, Vol 40, Iss 3, Pp 261-267 (2023)
BackgroundA large amount of iron deposition in the brain can cause neuronal damage by inducing oxidative stress, neuroinflammation, and abnormal mitochondrial function. In addition, iron deposition is also reported to be closely related to the pathog
Externí odkaz:
https://doaj.org/article/ceebed513b2c452eb8be1a3463a2d228
Autor:
Kevin L. Batenburg, Claudia Sestito, Paulien Cornelissen-Steijger, Jan R. T. van Weering, Leo S. Price, Vivi M. Heine, Wiep Scheper
Publikováno v:
Biological Procedures Online, Vol 25, Iss 1, Pp 1-14 (2023)
Abstract Background Intraneuronal tau aggregation is the major pathological hallmark of neurodegenerative tauopathies. It is now generally acknowledged that tau aggregation also affects astrocytes in a cell non-autonomous manner. However, mechanisms
Externí odkaz:
https://doaj.org/article/dc48a5e9b803420cb8bd12454e349851
Akademický článek
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Akademický článek
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Publikováno v:
Neurobiology of Disease, Vol 178, Iss , Pp 106011- (2023)
Metabolic reactions within cells occur in various isolated compartments with or without borders, the latter being known as membrane-less organelles (MLOs). The MLOs show liquid-like properties and are formed by a process known as liquid-liquid phase
Externí odkaz:
https://doaj.org/article/834e1813982545c59488ffd7199d30f6