Movement disorders are linked to TDP-43 burden in the substantia nigra of FTLD-TDP brain donors

Autor: Fiondella, Luigi, Gami-Patel, Priya, Blok, Christian A, Rozemuller, Annemieke J M, Hoozemans, Jeroen J M, Pijnenburg, Yolande A L, Scarioni, Marta, Dijkstra, Anke A

Publikováno v: Acta neuropathologica communications, 11(1). BioMed Central

Movement disorders (MD) have been linked to degeneration of the substantia nigra (SN) in Parkinson's disease and include bradykinesia, rigidity, and tremor. They are also present in frontotemporal dementia (FTD), where MD have been linked to frontote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::7d0720449c4d6ff2f9325340b49063f1
https://pure.knaw.nl/portal/en/publications/cc8e1c77-d7b7-40fc-92b5-a1137ce32075

Tau promotes oxidative stress-associated cycling neurons in S phase as a pro-survival mechanism : possible implication for Alzheimer’s disease

Autor: Marine Denechaud, Sarah Geurs, Thomas Comptdaer, Séverine Bégard, Alejandro Garcia-Núñez, Louis-Adrien Pechereau, Thomas Bouillet, Yannick Vermeiren, Peter P. De Deyn, Romain Perbet, Vincent Deramecourt, Claude-Alain Maurage, Michiel Vanderhaegen, Sebastiaan Vanuytven, Bruno Lefebvre, Elke Bogaert, Nicole Déglon, Thierry Voet, Morvane Colin, Luc Buée, Bart Dermaut, Marie-Christine Galas

Publikováno v: Progress in neurobiology
Progress in neurobiology 223 (2023)
PROGRESS IN NEUROBIOLOGY
Progress in neurobiology, 223
Progress in neurobiology, vol. 223, pp. 102386

Multiple lines of evidence have linked oxidative stress, tau pathology and neuronal cell cycle re-activation to Alzheimer's disease (AD). While a prevailing idea is that oxidative stress-induced neuronal cell cycle reactivation acts as an upstream tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e268b1fec3551c4f90a3443453adf541
https://hdl.handle.net/10067/1929640151162165141

Insulin Resistance as a Common Link Between Current Alzheimer’s Disease Hypotheses

Autor: Gabriel Servilha-Menezes, Rui M.P. da Silva-Júnior, Melita Salkovic-Petrisic, Suélen Santos Alves, Jan Homolak, Norberto Garcia-Cairasco

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Almost 115 years ago, Alois Alzheimer described Alzheimer’s disease (AD) for the first time. Since then, many hypotheses have been proposed. However, AD remains a severe health public problem. The current medical approaches for AD are limited to sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce9c906714bf33029469a2037701a83a
https://doi.org/10.3233/jad-210234

Extracellular vesicles: major actors of heterogeneity in tau spreading among human tauopathies

Autor: Leroux, Elodie, Perbet, Romain, Caillerez, Raphaëlle, Richetin, Kevin, Lieger, Sarah, Espourteille, Jeanne, Bouillet, Thomas, Bégard, Séverine, Danis, Clément, Loyens, Anne, Toni, Nicolas, Déglon, Nicole, Deramecourt, Vincent, Schraen-Maschke, Susanna, Buée, Luc, Colin, Morvane

Publikováno v: Molecular Therapy
Molecular Therapy, 2021, pp.S1525-0016(21)00475-5. ⟨10.1016/j.ymthe.2021.09.020⟩
Molecular Therapy, vol. 30, no. 2, pp. 782-797
Molecular Therapy, Cell Press, 2021, pp.S1525-0016(21)00475-5. ⟨10.1016/j.ymthe.2021.09.020⟩

Tauopathies are neurodegenerative diseases characterized by tau inclusions in brain cells. Seed-competent tau species have been suggested to spread from cell to cell in a stereotypical manner, indicating that this may involve a prion-like mechanism.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0cf6496faeec34f02544fd301f7cdf92
https://www.hal.inserm.fr/inserm-03356237

Applying the ATN scheme in a memory clinic population

Autor: Daniele Altomare, Marissa D. Zwan, Wiesje M. van der Flier, Wiesje Pelkmans, Charlotte E. Teunissen, Maqsood Yaqub, Ingrid S. van Maurik, Femke H. Bouwman, Bart N.M. van Berckel, Frederik Barkhof, Giovanni B. Frisoni, Arno de Wilde, Philip Scheltens, Rik Ossenkoppele, Colin Groot

Publikováno v: Neurology, Vol. 93, No 17 (2019) pp. e1635-e1646
Neurology, 93(17), e1635-e1646. Lippincott Williams and Wilkins
Altomare, D, de Wilde, A, Ossenkoppele, R, Pelkmans, W, Bouwman, F, Groot, C, van Maurik, I, Zwan, M, Yaqub, M, Barkhof, F, van Berckel, B N, Teunissen, C E, Frisoni, G B, Scheltens, P & van der Flier, W M 2019, ' Applying the ATN scheme in a memory clinic population : The ABIDE project ', Neurology, vol. 93, no. 17, pp. e1635-e1646 . https://doi.org/10.1212/WNL.0000000000008361

ObjectiveTo apply the ATN scheme to memory clinic patients, to assess whether it discriminates patient populations with specific features.MethodsWe included 305 memory clinic patients (33% subjective cognitive decline [SCD]: 60 ± 9 years, 61% M; 19%

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::013f63c0c6ce85b66caf99e74d813127
https://doi.org/10.1212/wnl.0000000000008361