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Akademický článek

Selective RNA Processing and Stabilization are Multi‐Layer and Stoichiometric Regulators of Gene Expression in Escherichia coli

Autor: Daixi Liu, Haibo Lv, Yafei Wang, Jinyu Chen, Dexin Li, Ranran Huang

Publikováno v: Advanced Science, Vol 10, Iss 33, Pp n/a-n/a (2023)

Abstract Selective RNA processing and stabilization (SRPS) facilitates the differential expression of multiple genes in polycistronic operons. However, how the coordinated actions of SRPS‐related enzymes affect stoichiometric regulation remains unc

Externí odkaz: https://doaj.org/article/c01be1e946e14e899c9578c5a67c70ba

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Akademický článek

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Akademický článek

Amyotrophic Lateral Sclerosis associated FUS mutation shortens mitochondria and induces neurotoxicity

Autor: Tadashi Nakaya, Manolis Maragkakis

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)

Abstract Amyotrophic Lateral Sclerosis (ALS) is a lethal neurodegenerative disorder that primarily affects motor neurons. Dominant mutations in the RNA binding protein Fused in Sarcoma (FUS) have been identified as causative factors of ALS. Mutation,

Externí odkaz: https://doaj.org/article/cb8569e4b09147fbb1c3b6d12bdc69e5

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Akademický článek

The miR-28-5p Targetome Discovery Identified SREBF2 as One of the Mediators of the miR-28-5p Tumor Suppressor Activity in Prostate Cancer Cells

Autor: Sofia Fazio, Gabriele Berti, Francesco Russo, Monica Evangelista, Romina D’Aurizio, Alberto Mercatanti, Marco Pellegrini, Milena Rizzo

Publikováno v: Cells, Vol 9, Iss 2, p 354 (2020)

miR-28-5p is downregulated in some tumor tissues in which it has been demonstrated to have tumor suppressor (TS) activity. Here, we demonstrate that miR-28-5p acts as a TS in prostate cancer (PCa) cells affecting cell proliferation/survival, as well

Externí odkaz: https://doaj.org/article/0b85f59c8cd14a4ab905db052a9acc62

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Akademický článek

Integrated Analysis of microRNA and mRNA Expression Profiles: An Attempt to Disentangle the Complex Interaction Network in Attention Deficit Hyperactivity Disorder

Autor: Nicoletta Nuzziello, Francesco Craig, Marta Simone, Arianna Consiglio, Flavio Licciulli, Lucia Margari, Giorgio Grillo, Sabino Liuni, Maria Liguori

Publikováno v: Brain Sciences, Vol 9, Iss 10, p 288 (2019)

Attention Deficit Hyperactivity Disorder (ADHD) is a childhood-onset neurodevelopmental disorder, whose etiology and pathogenesis are still largely unknown. In order to uncover novel regulatory networks and molecular pathways possibly related to ADHD

Externí odkaz: https://doaj.org/article/91fbaf39ecd248728b9b556eed5654ca

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Thirty Years of sRNA-Mediated Regulation in Staphylococcus aureus: From Initial Discoveries to In Vivo Biological Implications

Autor: Guillaume Menard, Chloé Silard, Marie Suriray, Astrid Rouillon, Yoann Augagneur

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2022, 23 (13), pp.7346. ⟨10.3390/ijms23137346⟩

International audience; Staphylococcus aureus is a widespread livestock and human pathogen that colonizes diverse microenvironments within its host. Its adaptation to the environmental conditions encountered within humans relies on coordinated gene e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b9a653f8fb2557747b7ab5684cd5ddd
https://hal.science/hal-03775206/document

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Cross-Linking Ligation and Sequencing of Hybrids (qCLASH) Reveals an Unpredicted miRNA Targetome in Melanoma Cells

Autor: Ines Kozar, Demetra Philippidou, Christiane Margue, Lauren A. Gay, Rolf Renne, Stephanie Kreis

Publikováno v: Cancers
Volume 13
Issue 5
Cancers, Vol 13, Iss 1096, p 1096 (2021)

Simple Summary miRNAs are omnipresent short non-coding RNA molecules, which post-transcriptionally fine-tune the expression of most protein-coding genes in health and disease. In cancer, miRNAs have been described to directly regulate the amounts of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e344590b3bb35fab05457753b9937d

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Genome‐scale, single‐cell‐type resolution of microRNA activities within a whole plant organ

Autor: Olivier Voinnet, Matthias Hirsch-Hoffmann, Nicolás G. Bologna, Christopher A. Brosnan, Alexis Sarazin, PeiQi Lim

Publikováno v: The EMBO Journal, 38 (12)
EMBO J
Digital.CSIC. Repositorio Institucional del CSIC
instname

Loaded into ARGONAUTE(AGO) proteins, eukaryotic micro(mi)RNAs regulate gene expression via cleavage, translational repression, and/or accelerated decay of sequence‐complementary target transcripts. Despite their importance in development, cell iden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59e2d6d576725b8a183bf0581178449e
https://hdl.handle.net/20.500.11850/347706

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