Zobrazeno 1 - 10
of 1 304
pro vyhledávání: '"targeted next-generation sequencing"'
Autor:
Hongyu Chen, Guangjie Chen, Fengxia Li, Yong Huang, Linfeng Zhu, Yijun Zhao, Ziyi Jiang, Xiang Yan, Lan Yu
Publikováno v:
Biology of Sex Differences, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Purpose 46,XY disorders of sex development (46,XY DSD) are characterized by incomplete masculinization of genitalia with reduced androgenization. Accurate clinical management remains challenging, especially based solely on physical examinati
Externí odkaz:
https://doaj.org/article/73c986443fd64155b71cee6df2586e80
Autor:
Fan Wu, Nani Li, Xiufeng Wu, Mulan Chen, Weiwei Huang, Xinhua Chen, Yi Hong, Lili Wang, Kan Chen, Lin Lin, Minjin You, Jian Liu
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background The prognosis of breast cancer patients with visceral metastasis (VM) is significantly worse than that of patients without VM. We aimed to evaluate EZH2 (enhancer of zeste homolog 2) mutation as a biomarker associated with VM. Met
Externí odkaz:
https://doaj.org/article/38b6e4869a3344e6a7c3747477a45b49
Autor:
Muyun Wei, Shaowei Mao, Shuangshuang Li, Kangyi Gu, Dejian Gu, Shengjie Bai, Xinhua Lu, Min Li
Publikováno v:
Annals of Clinical Microbiology and Antimicrobials, Vol 23, Iss 1, Pp 1-12 (2024)
Abstract Background Accurate identification of the etiology of lower respiratory tract infections (LRTI) is crucial, particularly for immunocompromised patients with more complex etiologies. The advent of next-generation sequencing (NGS) has enhanced
Externí odkaz:
https://doaj.org/article/49694d7b09004b1c823fe55c7b1cad13
Publikováno v:
Italian Journal of Pediatrics, Vol 50, Iss 1, Pp 1-8 (2024)
Abstract Background This study aimed to compare targeted next-generation sequencing (tNGS) with metagenomic next-generation sequencing (mNGS) for pathogen detection in infants with severe postoperative pneumonia after congenital heart surgery. Method
Externí odkaz:
https://doaj.org/article/3282f7e51f264f40aff85e6094430d73
Autor:
Jing-Ying Zhang, Chun-Rong Chen, Jia-Yue Qin, Di-Ying Shen, Li-Xia Liu, Hua Song, Tian Xia, Wei-Qun Xu, Yan Wang, Feng Zhu, Mei-Xin Fang, He-Ping Shen, Chan Liao, Ao Dong, Shan-Bo Cao, Yong-Min Tang, Xiao-Jun Xu
Publikováno v:
European Journal of Medical Research, Vol 29, Iss 1, Pp 1-12 (2024)
Abstract Background NUP98 rearrangements (NUP98-r) are rare but overrepresented mutations in pediatric acute myeloid leukemia (AML) patients. NUP98-r is often associated with chemotherapy resistance and a particularly poor prognosis. Therefore, chara
Externí odkaz:
https://doaj.org/article/52408fdbd86146d68ff9ac16e4e57044
Autor:
Giovanni Ghielmetti, Tanya J. Kerr, Netanya Bernitz, Sinegugu K. Mhlophe, Elizma Streicher, Andre G. Loxton, Robin M. Warren, Michele A. Miller, Wynand J. Goosen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Animal tuberculosis significantly challenges global health, agriculture, and wildlife conservation efforts. Mycobacterial cultures are resource-intensive, time-consuming, and challenged by heterogeneous populations. In this study, we employe
Externí odkaz:
https://doaj.org/article/107a15af0c0941e7a1ac21cdff591806
Publikováno v:
BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-7 (2024)
Abstract Background The global prospective surveillance data showed the re-emergence of mycoplasma pneumoniae pneumonia (MPP) in Europe and Asia after the coronavirus disease 2019 pandemic. We sought to observe the effect of macrolide antibiotics in
Externí odkaz:
https://doaj.org/article/6ba8973bc6294dfc924b7515fef39e14
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
BackgroundInfections in patients with hematological malignancies (HM) are a significant cause of morbidity and mortality. Timely and effective empirical anti-infective treatment can reduce the infection-related mortality rate. Targeted next-generatio
Externí odkaz:
https://doaj.org/article/7e8b7713568d465aa0314497e6f81f1f
Autor:
Yuyao Yin, Pengyuan Zhu, Yifan Guo, Yingzhen Li, Hongbin Chen, Jun Liu, Lingxiao Sun, Shuai Ma, Chaohui Hu, Hui Wang
Publikováno v:
EBioMedicine, Vol 107, Iss , Pp 105307- (2024)
Summary: Background: Shotgun metagenomic next-generation sequencing (mNGS) is widely used to detect pathogens in bronchoalveolar lavage fluid (BALF). However, mNGS is complex and expensive. This study explored the feasibility of targeted next-generat
Externí odkaz:
https://doaj.org/article/3254bf79d34f48d088ed98843c3ffa1e
Autor:
Tamires Ferreira da Silva, Juscelino Carvalho de Azevedo, Eliel Barbosa Teixeira, Samir Mansour Moraes Casseb, Fabiano Cordeiro Moreira, Paulo Pimentel de Assumpção, Sidney Emanuel Batista dos Santos, Danielle Queiroz Calcagno
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Identifying mutations in cancer-associated genes to guide patient treatments is essential for precision medicine. Circulating tumor DNA (ctDNA) offers valuable insights for early cancer detection, treatment assessment, and surveillance. However, a ke
Externí odkaz:
https://doaj.org/article/2f1005ebd17041519f9991c84da6c1d6