Zobrazeno 1 - 10
of 6 877
pro vyhledávání: '"target-therapy"'
Publikováno v:
Breast Cancer: Targets and Therapy, Vol Volume 16, Pp 845-853 (2024)
Feng Zhao,1 Hongzhen Zhang2 1The First Hospital of Anhui University of Science and Technology, Huainan, Anhui, People’s Republic of China; 2Anhui University of Science and Technology, Huainan, Anhui, People’s Republic of ChinaCorrespondence: Hong
Externí odkaz:
https://doaj.org/article/3973a57306414a0b8b53871e21ac2d33
Autor:
Ying Yi, Lingfeng Dai, Yaqin Lan, Changyuan Tan, Dania M. Vázquez-Blomquist, Guirong Zeng, Dejian Jiang, Ke Yang, Silvio E. Perea, Yasser Perera
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Overall response rates in advanced Non-Small Cell Lung Cancer (NSCLC) remains low. Thus, novel molecular targets, tailored drugs and/or drug combinations are needed. Casein Kinase-2 (CK2) is a constitutively active and frequently over-expres
Externí odkaz:
https://doaj.org/article/1bd07b02822f46a19511f025136c0657
Autor:
Francesca Ruzzi, Chiara Cappello, Maria Sofia Semprini, Laura Scalambra, Stefania Angelicola, Olga Maria Pittino, Lorena Landuzzi, Arianna Palladini, Patrizia Nanni, Pier-Luigi Lollini
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-10 (2024)
Abstract Lipid rafts are dynamic microdomains enriched with cholesterol and sphingolipids that play critical roles in cellular processes by organizing and concentrating specific proteins involved in signal transduction. The interplay between lipid ra
Externí odkaz:
https://doaj.org/article/0f01f19499ac4787836667014821c1c1
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-58 (2024)
Abstract Heat shock proteins are essential molecular chaperones that play crucial roles in stabilizing protein structures, facilitating the repair or degradation of damaged proteins, and maintaining proteostasis and cellular functions. Extensive rese
Externí odkaz:
https://doaj.org/article/4d5d2c5da47d42cea03597681a210e8a
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-15 (2024)
Abstract Soft tissue sarcomas (STS) have long been a formidable challenge in oncology, partly because of their rarity and diversity, which complicates large-scale studies and slows the advent of new treatments. Traditionally anchored by anthracycline
Externí odkaz:
https://doaj.org/article/7ef21262418c46b9b7f1ab1e7ac20ce2
Publikováno v:
International Journal of Nanomedicine, Vol Volume 19, Pp 9121-9143 (2024)
Yanan Huang,1,* Yunfeng Wang,2,* Tianyu Zheng,1,* Shuang Nie,1 Yanli Wang,3 Hui Shen,1 Fengfeng Mo1 1Department of Naval Nutrition and Food Hygiene, Faculty of Navy Medicine, Naval Medical University, Shanghai, People’s Republic of Chin
Externí odkaz:
https://doaj.org/article/48127cf3b1c74377bafbcaa70a919a4e
Publikováno v:
Biomedical Technology, Vol 7, Iss , Pp 32-45 (2024)
Ischemic stroke (IS), a major cause of death and disability globally, requires innovative therapeutic approaches due to its complex pathology. Nature medicine (NM) offers promising treatments through its bioactive compounds, which target the multifac
Externí odkaz:
https://doaj.org/article/4c862c6f3a354e5294661bd2a3e9a11b
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-32 (2024)
Abstract Ischemic stroke poses significant challenges in terms of mortality and disability rates globally. A key obstacle to the successful treatment of ischemic stroke lies in the limited efficacy of administering therapeutic agents. Leveraging the
Externí odkaz:
https://doaj.org/article/2d8b634ffeb84add908566b6ec1cf7dd
Autor:
Valentina Piastra, Federica Ganci, Andrea Sacconi, Angelina Pranteda, Matteo Allegretti, Roberta Bernardini, Martina Serra, Barbara Lupo, Emanuela Dell’Aquila, Gianluigi Ferretti, Edoardo Pescarmona, Armando Bartolazzi, Giovanni Blandino, Livio Trusolino, Gianluca Bossi
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-18 (2024)
Abstract Background Colorectal cancer (CRC) is the third most common type of cancer and the second leading cause of cancer-related deaths worldwide, with a survival rate near to 10% when diagnosed at an advanced stage. Hence, the identification of ne
Externí odkaz:
https://doaj.org/article/536b2932e0ac43d4922bd78ef035bbe1
Publikováno v:
BMC Pregnancy and Childbirth, Vol 24, Iss 1, Pp 1-16 (2024)
Abstract Background The pregnant women with intrahepatic cholestasis were at high risk of fetal distress, preterm birth and unexpected stillbirth. Intrahepatic cholestasis of pregnancy (ICP) was mainly caused by disorder of bile acid metabolism, wher
Externí odkaz:
https://doaj.org/article/0a22822c670f4c50ae87a94566234f59