Zobrazeno 1 - 10
of 2 742
pro vyhledávání: '"target prediction"'
Autor:
Tauheed Suddal, Mudassar Fareed Awan, Sajed Ali, Muhammad Farhan Sarwar, Shahzad Iqbal, Qurban Ali, Muhammad Arshad Javed, Muhammad Y. Alshahrani
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Rice (Oryza sativa) is a staple food for billions of people across the globe, that feeds nearly three-quarters of the human population on Earth, particularly in Asian countries. Rice yield has been drastically reduced and severely affected b
Externí odkaz:
https://doaj.org/article/e640786ba6ff4d3994f94649b57fd8cf
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 3020-3029 (2024)
Colorectal cancer (CRC) is the third most diagnosed cancer and the second deadliest cancer worldwide representing a major public health problem. In recent years, increasing evidence has shown that microRNA (miRNA) can control the expression of target
Externí odkaz:
https://doaj.org/article/08ffd3bdb0aa42ee971898892a20476d
Autor:
Haydara Ammar Hasan, Jiseong Lee, Sunil Kumar, Saleh Alfarraj, Sulaiman Ali Alharbi, Manu Pant, Hoon Kim, Bijo Mathew
Publikováno v:
Applied Biological Chemistry, Vol 67, Iss 1, Pp 1-10 (2024)
Abstract Five dimethylamino-based chalcone derivatives (AC) were synthesized and evaluated for their inhibition degree against monoamine oxidase (MAO) enzymes. All AC compounds showed better inhibitory activity against MAO-B than that against MAO-A.
Externí odkaz:
https://doaj.org/article/983fa1a2e9fa4d23beeee245f329c0a7
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-12 (2024)
Abstract It is well-accepted that knowledge of a small molecule’s target can accelerate optimization. Although chemogenomic databases are helpful resources for predicting or finding compound interaction partners, they tend to be limited and poorly
Externí odkaz:
https://doaj.org/article/6484a0fe4b8e4b3a8208085d2463d598
Autor:
Jin Liu, Yike Gui, Jingxin Rao, Jingjing Sun, Gang Wang, Qun Ren, Ning Qu, Buying Niu, Zhiyi Chen, Xia Sheng, Yitian Wang, Mingyue Zheng, Xutong Li
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 7, Pp 2927-2941 (2024)
Ensuring drug safety in the early stages of drug development is crucial to avoid costly failures in subsequent phases. However, the economic burden associated with detecting drug off-targets and potential side effects through in vitro safety screenin
Externí odkaz:
https://doaj.org/article/062c5287154b4c81a56d547d7f1470da
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
The issue of antimicrobial resistance (AMR) in pathogenic microorganisms has emerged as a global public health crisis, posing a significant threat to the modern healthcare system. The advent of Artificial Intelligence (AI) and Machine Learning (ML) t
Externí odkaz:
https://doaj.org/article/17fd81b057064264bd0b864c6f5225d5
Autor:
Vineeta Pandey, Aarshi Srivastava, Akhtar Ali, Ramwant Gupta, Muhammad Shafiq Shahid, Rajarshi Kumar Gaur
Publikováno v:
Frontiers in Plant Science, Vol 15 (2024)
The begomoviruses are the most economically damaging pathogens that pose a serious risk to India’s chilli crop and have been associated with the chilli leaf curl disease (ChiLCD). Chilli cultivars infected with begomovirus have suffered significant
Externí odkaz:
https://doaj.org/article/01da127c1a9c48dda42cc051758b4531
Autor:
Teng Wang, Siyuan Cui, Chunyi Lyu, Zhenzhen Wang, Zonghong Li, Chen Han, Weilin Liu, Yan Wang, Ruirong Xu
Publikováno v:
Heliyon, Vol 10, Iss 17, Pp e36155- (2024)
Acute myeloid leukemia (AML), as the most common malignancy of the hematopoietic system, poses challenges in treatment efficacy, relapse, and drug resistance. In this study, we have utilized 151 RNA sequencing datasets, 194 DNA methylation datasets,
Externí odkaz:
https://doaj.org/article/0a9f0a1f902b49cb94a48ac94476b831
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-18 (2024)
Abstract Background MicroRNAs play a critical role in regulating gene expression by binding to specific target sites within gene transcripts, making the identification of microRNA targets a prominent focus of research. Conventional experimental metho
Externí odkaz:
https://doaj.org/article/2ab927f0a56a4491b644db819958c883
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-6 (2024)
Abstract Sepsis is recognized as a major contributor to the global disease burden, but there is a lack of specific and effective therapeutic agents. Utilizing Mendelian randomization (MR) methods alongside evidence of causal genetics presents a chanc
Externí odkaz:
https://doaj.org/article/3722e2c2a5864fb0b871bef8cb9f87df