Zobrazeno 1 - 10
of 1 189
pro vyhledávání: '"tank‐binding kinase"'
Publikováno v:
Shanghai Jiaotong Daxue xuebao. Yixue ban, Vol 44, Iss 3, Pp 301-311 (2024)
Objective·To analyze the relationship between the expression level of interferon regulatory factor 3 (IRF3) in colorectal cancer and its clinicopathological features and prognosis, and to observe the effects of IRF3 overexpression on the proliferati
Externí odkaz:
https://doaj.org/article/1c1fe6d32aac4a4aaca33dd70ff94f6f
Publikováno v:
Journal of Experimental Pharmacology, Vol Volume 15, Pp 407-421 (2023)
Kanoktip Petcharat,1 Narongsuk Munkong,2 Rungthip Thongboontho,1 Widsanusan Chartarrayawadee,3 Arthid Thim-Uam1 1Division of Biochemistry, School of Medical Sciences, University of Phayao, Phayao, 56000, Thailand; 2Department of Pathology, School of
Externí odkaz:
https://doaj.org/article/ed198000474d4991979953cf963b052d
Autor:
Xiaoli Liu, Yangdong Liu, Wenjun Chai, Mingxia Yan, Hui Li, Jing Li, Lei Sun, Yue Cao, Qian Liu, Yuexi Sun, Hongyu Pan
Publikováno v:
Molecular and Cellular Probes, Vol 71, Iss , Pp 101923- (2023)
Lung cancer is one of the most common malignant tumors and has a poor prognosis and a low survival rate. Traditional treatments, such as radiotherapy and chemotherapy, still face some challenges because of high drug resistance and toxicity. Therefore
Externí odkaz:
https://doaj.org/article/db4365d193bf40c48f89395fca35c6bb
Autor:
Ningning Wang, Entao Li, Huifang Deng, Lanxin Yue, Lei Zhou, Rina Su, Baokun He, Chengcai Lai, Gaofu Li, Yuwei Gao, Wei Zhou, Yue Gao
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 13, Iss 1, Pp 11-23 (2023)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced cytokine storms constitute the primary cause of coronavirus disease 19 (COVID-19) progression, severity, criticality, and death. Glucocorticoid and anti-cytokine therapies are frequ
Externí odkaz:
https://doaj.org/article/431fac8d88d94b72b587dba4dfded26f
Autor:
Anna Nakagawa, Sumio Hayakawa, Yinglan Cheng, Azusa Honda, Ryo Yuzawa, Rei Ogawa, Yumiko Oishi
Publikováno v:
FEBS Open Bio, Vol 13, Iss 1, Pp 185-194 (2023)
Macrophages distributed in tissues throughout the body contribute to homeostasis. In the inflammatory state, macrophages undergo mechanical stress that regulates the signal transduction of immune responses and various cellular functions. However, the
Externí odkaz:
https://doaj.org/article/6dafd7e7c9714fde946bed9b0195ca0e
Autor:
Lei Li, Jialiang Luo, Zhengyumeng Zhu, Qishan Xu, Ping Wang, Bo Chang, Di Wang, Lu Yu, Xiao Lu, Jia Zhou, Daming Zuo, Qingyun Chen
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 6 (2022)
ABSTRACT The innate immune system is the first line of host defense against microbial infections. During virus infection, pattern recognition receptors (PRRs) are engaged to detect specific viral components, such as viral RNA or DNA, and regulate the
Externí odkaz:
https://doaj.org/article/9da45858944c4542a8559dab6c941669
Autor:
Yuval Gurfinkel, Nicole Polain, Krushna Sonar, Penelope Nice, Ricardo L. Mancera, Sarah Lyn Rea
Publikováno v:
Neurobiology of Disease, Vol 174, Iss , Pp 105859- (2022)
Mutations in the Tank-binding kinase 1 (TBK1) gene were identified in 2015 in individuals with frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). They account for ∼3–4% of cases. To date, over 100 distinct mutations
Externí odkaz:
https://doaj.org/article/224b6571ec0e4e29976a4da442979b09
Autor:
Fengxia Du, Huiwei Sun, Fang Sun, Shiwei Yang, Haidong Tan, Xiaojuan Li, Yantao Chai, Qiyu Jiang, Dongdong Han
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The protein kinase, TANK-binding kinase 1 (TBK1), not only regulates various biological processes but also functions as an important regulator of human oncogenesis. However, the detailed function and molecular mechanisms of TBK1 in hepatocellular car
Externí odkaz:
https://doaj.org/article/d141e608f1574ced883172f4d8f75c8d
Autor:
Ying-Qian Lu, Jian-Min Chen, Han Lin, Shu-Yan Feng, Chun-Hui Che, Chang-Yun Liu, Hua-Pin Huang, Zhang-Yu Zou
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
TANK-binding kinase 1 (TBK1) has been identified as a causative gene of amyotrophic lateral sclerosis (ALS) in the Caucasian population in 2015. Here, we sequenced for TBK1 variants in a cohort of 15 familial ALS (fALS) and 275 sporadic ALS (sALS) of
Externí odkaz:
https://doaj.org/article/84fe27d9a7f048a6aaeeb571bfa6e91d
Publikováno v:
Advances in Human Biology, Vol 10, Iss 1, Pp 11-15 (2020)
Introduction: Multiple sclerosis (MS) is one of the most common inflammatory autoimmune diseases in the central nervous system, which affects individuals ranged between 20 and 40 years of age. There is still no gene or genes set that is unique to the
Externí odkaz:
https://doaj.org/article/ac192e8e32a64e999ccd954972005848