Zobrazeno 1 - 10
of 66
pro vyhledávání: '"tacrine hybrids"'
Akademický článek
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Autor:
Florian Nachon, Ondrej Soukup, Luciana de Camargo Nascente, Fabien Chantegreil, Michele Rossi, Marco Malaguti, Maria Laura Bolognesi, Sarah de Melo Viana Teixeira, Michela Freschi, Silvana Hrelia, Manuela Bartolini, Alessandra Salerno, Luiz Antonio Soares Romeiro, Christian Bergamini, Cristina Angeloni, Lukas Prchal
Publikováno v:
Journal of Medicinal Chemistry
The multifactorial nature of Alzheimer's disease (AD) is a reason for the lack of effective drugs as well as a basis for the development of "multi-target-directed ligands" (MTDLs). As cases increase in developing countries, there is a need of new dru
Autor:
Rajeshwari Rajeshwari, Karam Chand, Emanuel Candeias, Sandra M. Cardoso, Sílvia Chaves, M. Amélia Santos
Publikováno v:
Molecules, Vol 24, Iss 3, p 587 (2019)
Research on neurodegenerative brain disorders, namely the age-dependent Alzheimer’s disease (AD), has been intensified in the last decade due to the absence of a cure and the recognized increasing of life expectancy for populations. To address the
Externí odkaz:
https://doaj.org/article/ab10c78bc0154f96b152fc4f369db662
Akademický článek
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Publikováno v:
Marine Drugs, Vol 16, Iss 9, p 293 (2018)
A marine natural product, pulmonarin B (1), and a series of related tacrine hybrid analogues were synthesized and evaluated as cholinesterase (ChE) inhibitors. The in vitro ChE assay results revealed that 1 showed moderate dual acetylcholinesterase (
Externí odkaz:
https://doaj.org/article/37a9bb3a17294e2ca245df00fbdef97f
Publikováno v:
Current Neuropharmacology
Tacrine is a potent inhibitor of cholinesterases (acetylcholinesterase and butyrylcholinesterase) that shows limiting clinical application by liver toxicity. In spite of this, analogues of tacrine are considered as a model inhibitor of cholinesterase
Akademický článek
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Autor:
Anuraj Nayarisseri, Mohammed Marunnan Sahila, Srinivas Bandaru, Pallikkara Pulikkal Babitha, Sivanpillai Sureshkumar
Publikováno v:
Bioinformation
The present AChE inhibitors have been successful in the treatment of Alzheimer׳s Diseases however suffers serious side effects. Therefore in this view, the present study was sought to identify compounds with appreciable pharmacological profile targe
Tacrine-based Multifunctional Agents in Alzheimer's Disease: An Old Story in Continuous Development§
Autor:
Andrea Milelli, Vincenza Andrisano, Huan Huan Chen, Nicole Ticchi, Nibal Betari, Vincenzo Tumiatti, Angela De Simone
Publikováno v:
Current Medicinal Chemistry. 24
The design of multifunctional agents represents one of the most active research field in medicinal chemistry. In particular, tacrine, a well known Acetylcholinesterase inhibitor, is one of the most used starting point to develop multifunctional ligan
Autor:
Sílvia Chaves, M. Amélia Santos, Karam Chand, Rajeshwari Rajeshwari, Emanuel Candeias, Sandra M. Cardoso
Publikováno v:
Molecules
Molecules, Vol 24, Iss 3, p 587 (2019)
Volume 24
Issue 3
Molecules, Vol 24, Iss 3, p 587 (2019)
Volume 24
Issue 3
Research on neurodegenerative brain disorders, namely the age-dependent Alzheimer&rsquo
s disease (AD), has been intensified in the last decade due to the absence of a cure and the recognized increasing of life expectancy for populations. To add
s disease (AD), has been intensified in the last decade due to the absence of a cure and the recognized increasing of life expectancy for populations. To add