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Akademický článek

A Computational Study of the Effects of Tachycardia-Induced Remodeling on Calcium Wave Propagation in Rabbit Atrial Myocytes

Autor: Márcia R. Vagos, Hermenegild Arevalo, Jordi Heijman, Ulrich Schotten, Joakim Sundnes

Publikováno v: Frontiers in Physiology, Vol 12 (2021)

In atrial cardiomyocytes without a well-developed T-tubule system, calcium diffuses from the periphery toward the center creating a centripetal wave pattern. During atrial fibrillation, rapid activation of atrial myocytes induces complex remodeling i

Externí odkaz: https://doaj.org/article/c83e991a5b1a425380f2748cd2312d61

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Akademický článek

Consequences of Atrial or Ventricular Tachypacing on the Heat Shock Proteins (HSP) level of Expression and Phosphorylation

Autor: Matthew Shorofsky, Ange Maguy, Stanley Nattel

Publikováno v: McGill Journal of Medicine, Vol 12, Iss 2 (2020)

Background - Uncontrolled atrial fibrillation (AF) results in complex changes in the cardiomyocyte electrical and contractile functioning that promote atrial remodeling and the continuation of AF. Recently there has been a growing interest in underst

Externí odkaz: https://doaj.org/article/73dac33761d44b149cf7139a8339456b

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Akademický článek

Inhibition of Histone Deacetylases Induces K+ Channel Remodeling and Action Potential Prolongation in HL-1 Atrial Cardiomyocytes

Autor: Patrick Lugenbiel, Katharina Govorov, Ann-Kathrin Rahm, Teresa Wieder, Dominik Gramlich, Pascal Syren, Nadine Weiberg, Claudia Seyler, Hugo A. Katus, Dierk Thomas

Publikováno v: Cellular Physiology and Biochemistry, Vol 49, Iss 1, Pp 65-77 (2018)

Background/Aims: Cardiac arrhythmias are triggered by environmental stimuli that may modulate expression of cardiac ion channels. Underlying epigenetic regulation of cardiac electrophysiology remains incompletely understood. Histone deacetylases (HDA

Externí odkaz: https://doaj.org/article/4061f2f00fa947b4a6470cb8259279da

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Akademický článek

Rapid Atrial Pacing Promotes Atrial Fibrillation Substrate in Unanesthetized Instrumented Rats

Autor: Wesam Mulla, Barak Hajaj, Sigal Elyagon, Michal Mor, Roni Gillis, Michael Murninkas, Hadar Klapper-Goldstein, Inbar Plaschkes, Vered Chalifa-Caspi, Sharon Etzion, Yoram Etzion

Publikováno v: Frontiers in Physiology, Vol 10 (2019)

AimThe self-perpetuating nature of atrial fibrillation (AF) has been a subject of intense research in large mammalian models exposed to rapid atrial pacing (RAP). Recently, rodents are increasingly used to gain insight into the pathophysiology of AF.

Externí odkaz: https://doaj.org/article/7d6dde48894b44219901f60cf3d67887

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Akademický článek

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Akademický článek

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Distress-Mediated Remodeling of Cardiac Connexin-43 in a Novel Cell Model for Arrhythmogenic Heart Diseases

Autor: Carl-Mattheis Wahl, Constanze Schmidt, Markus Hecker, Nina D. Ullrich

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 17; Pages: 10174

Gap junctions and their expression pattern are essential to robust function of intercellular communication and electrical propagation in cardiomyocytes. In healthy myocytes, the main cardiac gap junction protein connexin-43 (Cx43) is located at the i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a354addf1292463fe3266f5360bbfd2a
https://doi.org/10.3390/ijms231710174

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A Computational Study of the Effects of Tachycardia-Induced Remodeling on Calcium Wave Propagation in Rabbit Atrial Myocytes

Autor: Jordi Heijman, Márcia R. Vagos, Ulrich Schotten, Joakim Sundnes, Hermenegild Arevalo

Publikováno v: Frontiers in Physiology, Vol 12 (2021)
Frontiers in Physiology
Frontiers in physiology, 12:651428. Frontiers Media S.A.

In atrial cardiomyocytes without a well-developed T-tubule system, calcium diffuses from the periphery towards the center creating a centripetal wave pattern. During atrial fibrillation, rapid activation of atrial myocytes induces complex remodelling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81612264e0328cff98d75e0fd8d62273
https://www.frontiersin.org/articles/10.3389/fphys.2021.651428/full

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Consequences of Atrial or Ventricular Tachypacing on the Heat Shock Proteins (HSP) level of Expression and Phosphorylation

Autor: Stanley Nattel, Matthew Shorofsky, Ange Maguy

Publikováno v: McGill Journal of Medicine : MJM
McGill Journal of Medicine, Vol 12, Iss 2 (2020)
Scopus-Elsevier

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bcbb3be3a3c86d3fa1033f169571ed3
https://doi.org/10.26443/mjm.v12i2.277

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Leave the light on: chronic optogenetic tachypacing of human engineered cardiac tissue constructs

Autor: Natalia A. Trayanova, Patrick M. Boyle

Publikováno v: Cardiovasc Res
Cardiovascular Research

Aims Chronic tachypacing is commonly used in animals to induce cardiac dysfunction and to study mechanisms of heart failure and arrhythmogenesis. Human induced pluripotent stem cells (hiPSC) may replace animal models to overcome species differences a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::248dd91a4accde3942d6deac7a8f3aa1
https://europepmc.org/articles/PMC7314635/

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