Divergent Evolution of Eukaryotic CC- and A-Adding Enzymes

Autor: Erber, Lieselotte, Franz, Paul, Betat, Heike, Prohaska, Sonja, Mörl, Mario

Synthesis of the CCA end of essential tRNAs is performed either by CCA-adding enzymes or as a collaboration between enzymes restricted to CC- and A-incorporation. While the occurrence of such tRNA nucleotidyltransferases with partial activities seeme

Externí odkaz: https://ul.qucosa.de/id/qucosa%3A89302
https://ul.qucosa.de/api/qucosa%3A89302/attachment/ATT-0/

A Temporal Order in 5'- and 3'- Processing of Eukaryotic tRNAHis

Autor: Pöhler, Marie-Theres, Roach, Tracy M., Betat, Heike, Jackman, Jane E., Mörl, Mario

For flawless translation of mRNA sequence into protein, tRNAs must undergo a series of essential maturation steps to be properly recognized and aminoacylated by aminoacyl-tRNA synthetase, and subsequently utilized by the ribosome. While all tRNAs car

Externí odkaz: https://ul.qucosa.de/id/qucosa%3A88970
https://ul.qucosa.de/api/qucosa%3A88970/attachment/ATT-0/

Leçons biochimiques et statistiques de l’évolution du virus SARS-CoV-2 : nouveaux chemins pour combattre les virus

Autor: Yvon Maday, Gabriel Turinici, Antoine Danchin, Nicolas Cluzel, Amaury Lambert

Publikováno v: Comptes Rendus Biologies
Comptes Rendus Biologies, Elsevier, 2020, 343 (2), pp.177-209. ⟨10.5802/crbiol.16⟩
Comptes Rendus. Biologies
Comptes Rendus. Biologies, Académie des sciences (Paris), 2020, 343 (2), pp.177-209. ⟨10.5802/crbiol.16⟩

International audience; In the fight against the spread of COVID-19 the emphasis is on vaccination or on reactivating existing drugs used for other purposes. The tight links that necessarily exist between the virus as it multiplies and the metabolism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52429c9a1c0803b85c7e8186aa94af4f
https://doi.org/10.5802/crbiol.16

A RARE CAUSE OF SIDEROBLASTIC ANEMIA: TRNT1 MUTATION

Autor: Nese Yarali, Elif Benderlioğlu, Fatma Tuba Yildirim, Dilek Kaçar

Publikováno v: Hematology, Transfusion and Cell Therapy, Vol 43, Iss, Pp S28-S29 (2021)

Case report tRNA nucleotidyltransferase 1(TRNT1) gene encodes a polymerase involved in the maturation of cytosolic and mitochondrial transfer RNAs. Autosomal recessive loss of function mutations of TRNT1 leads sideroblastic anemia, immunodeficiency,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5705ce05b70efe7c0935b31898d6f80b
http://www.sciencedirect.com/science/article/pii/S2531137921011470

Schizosaccharomyces pombe contains separate CC- and A-adding tRNA nucleotidyltransferases

Autor: Judith S. Ngou, Paul B. M. Joyce, Nathalie E. Reid

Publikováno v: Biochemical and Biophysical Research Communications. 508:785-790

A specific cytidine-cytidine-adenosine (CCA) sequence is required at the 3′-terminus of all functional tRNAs. This sequence is added during tRNA maturation or repair by tRNA nucleotidyltransferase enzymes. While most eukaryotes have a single enzyme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a81c7ab51ea5fc5b0a3a515254930b
https://doi.org/10.1016/j.bbrc.2018.11.131