Zobrazeno 1 - 10
of 22
pro vyhledávání: '"tPA, tissue type plasminogen activator"'
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 24 (2020)
Background tPA (tissue‐type plasminogen activator) remains the only approved drug for acute ischemic stroke, with a potentially serious adverse effect: hemorrhagic transformation. The effects of antithrombotic agents on tPA‐induced hemorrhagic tr
Externí odkaz:
https://doaj.org/article/6ef1f269e65843eb8a6fadf163828f7e
Autor:
Andrew W. Duncan, Yong-Kook Kwon, Arman Zarnegar, Xinping Tan, Marie C. DeFrances, Evan R. Delgado, Jihong Ma, Reza Zarnegar
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 565-582 (2022)
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 565-582 (2022)
Background & Aims Nonalcoholic fatty liver disease is a frequent cause of hepatic dysfunction and is now a global epidemic. This ailment can progress to an advanced form called nonalcoholic steatohepatitis (NASH) and end-stage liver disease. Currentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30958d41e6dcdb7086f377f001ad86cf
https://pubmed.ncbi.nlm.nih.gov/34756982
https://pubmed.ncbi.nlm.nih.gov/34756982
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background tPA (tissue‐type plasminogen activator) remains the only approved drug for acute ischemic stroke, with a potentially serious adverse effect: hemorrhagic transformation. The effects of antithrombotic agents on tPA‐induced hemorrhagic tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb8915dda3070a82f45d89f2535d152b
https://doi.org/10.1161/jaha.120.017876
https://doi.org/10.1161/jaha.120.017876
Publikováno v:
Biochemical Pharmacology
Graphical abstract
On March 11, 2020, the World Health Organization (WHO) declared the severe acute respiratory syndrome caused by coronavirus 2 (SARS-CoV-2) a global pandemic. As of July 2020, SARS-CoV-2 has infected more than 14 million people
On March 11, 2020, the World Health Organization (WHO) declared the severe acute respiratory syndrome caused by coronavirus 2 (SARS-CoV-2) a global pandemic. As of July 2020, SARS-CoV-2 has infected more than 14 million people
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f360aa8ab7f316d50cacb98cc206343f
http://hdl.handle.net/2108/256570
http://hdl.handle.net/2108/256570
Autor:
Bethany L. Walton, Kimberley Foley, Maria M. Aleman, Edward M. Conway, Jonathan H. Foley, Alisa S. Wolberg, Micaela Harrasser, Victor Lei, Alice M. O'Byrne
Publikováno v:
EBioMedicine, Vol 5, Iss C, Pp 175-182 (2016)
EBioMedicine
EBioMedicine
Thrombus formation leading to vaso-occlusive events is a major cause of death, and involves complex interactions between coagulation, fibrinolytic and innate immune systems. Leukocyte recruitment is a key step, mediated partly by chemotactic compleme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47561409193c3a722aa4727441b5b8b2
http://www.sciencedirect.com/science/article/pii/S2352396416300445
http://www.sciencedirect.com/science/article/pii/S2352396416300445
Publikováno v:
Matrix Biology Plus, Vol 6, Iss, Pp 100038-(2020)
Matrix Biology Plus
Matrix Biology Plus
The extracellular matrix is engaged in an ever-evolving and elegant ballet of dynamic reciprocity that directly and bi-directionally regulates cell behavior. Homeostatic and pathophysiological changes in cell-matrix signaling cascades manifest as com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e0706f5167c8f3bf2dfb334f7e3546a
https://doi.org/10.1016/j.mbplus.2020.100038
https://doi.org/10.1016/j.mbplus.2020.100038
Publikováno v:
Neurobiology of Pain
Highlights • Late tPA-induced stable long-lasting CPSP in the mouse model. • Prevention of tPA-induced CPSP in LPA1 and LPA3 receptor KO mice. • Therapeutic effects of LPA1 and LPA3 antagonist against the established CPSP. • Evidence for LPA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3af6e8a999455a4b1bdaf1b85d9aa771
https://pubmed.ncbi.nlm.nih.gov/31194070
https://pubmed.ncbi.nlm.nih.gov/31194070
Publikováno v:
Neurobiology of Sleep and Circadian Rhythms
Neurobiology of Sleep and Circadian Rhythms, Vol 5, Iss, Pp 15-36 (2018)
Neurobiology of Sleep and Circadian Rhythms, Vol 5, Iss, Pp 15-36 (2018)
The mammalian circadian and sleep-wake systems are closely aligned through their coordinated regulation of daily activity patterns. Although they differ in their anatomical organization and physiological processes, they utilize overlapping regulatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9784b59b0d2c00d8e0ea1156b937fff4
https://pubmed.ncbi.nlm.nih.gov/31236509
https://pubmed.ncbi.nlm.nih.gov/31236509
Autor:
Peter J. Späth, E. Rusicke, Christoph Bucher, Alvaro Blanch, Olga Roche, Emanuela Pappalardo, István Karádi, Marco Cicardi, Mathias Juers, Inmaculada Martinez-Saguer, Roberto Giacomelli, Pál Novák Kaposi, Anthony J. Castaldo, Erik Waage Nielsen, Roberto Perricone, Arianna Kitzinger, Kalman Fay, Emel Aygören-Pürsün, Carlo Perricone, Christian Drouet, George Füst, Beáta Visy, C. Erik Hack, Vincenzo Penna, Hilary Longhurst, Tímea Kollár, George Harmat, István Nagy, Nicole Monnier, Éva Németh, Jan H. Nuijens, Bettina Fischer, Ursula Rauch, Peter L. Lakatos, Caterina De Carolis, Caroline O'Grady, Edit Takács, Margarita López-Trascasa, Henriette Farkas, Albrecht Gröner, George Szendei, Lilian Varga, Alvin E. Davis, Lennart Truedsson, Béla Fekete, John Jakenfelds, Andrea Zanichelli, Wolfhart Kreuz, Kayla Williams, Lajos Kalmar, Lorenza C. Zingale, Karen Binkley, Christiane Duponchel, Laurence Bouillet, Attila Tordai, Luigi Fontana, Angelo Agostoni, Konrad Bork
Publikováno v:
The Journal of Allergy and Clinical Immunology
Hereditary angioedema (HAE), a rare but life-threatening condition, manifests as acute attacks of facial, laryngeal, genital, or peripheral swelling or abdominal pain secondary to intra-abdominal edema. Resulting from mutations affecting C1 esterase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::683368948c5151ac254b136230a7bd26
https://doi.org/10.1016/j.jaci.2004.06.047
https://doi.org/10.1016/j.jaci.2004.06.047
Autor:
Satoshi Gando, Mineji Hayakawa, Atsushi Sawamura, Yuichiro Yanagida, Masahiro Ieko, Takeshi Wada, Yuichi Ono
Publikováno v:
Shock (Augusta, Ga.). 43(3)
Background: There are two opposing possibilities for the main pathogenesis of trauma-induced coagulopathy: an acute coagulopathy of trauma shock and disseminated intravascular coagulation with the fibrinolytic phenotype. Objective: The objective of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::236fbbde2e45d78aa79cb76ba1d166ad
https://pubmed.ncbi.nlm.nih.gov/25423126
https://pubmed.ncbi.nlm.nih.gov/25423126