Zobrazeno 1 - 10
of 2 896
pro vyhledávání: '"t-cell proliferation"'
Autor:
July Constanza Buitrago, Sarah L. Morris, Astrid Backhaus, Gesa Kaltenecker, Jagan Mohan Kaipa, Cyrille Girard, Stefan Schneider, Jens Gruber
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Induced pluripotent stem cell (iPSC)-derived mesenchymal stromal cells (iMSCs) offer a promising alternative to primary mesenchymal stromal cells (MSCs) and their derivatives, particularly extracellular vesicles (EVs), for use in advanced th
Externí odkaz:
https://doaj.org/article/205e2a97979849688a60c665a5ad8867
Autor:
Yaqin Zhang, Jingyi Ren, Zhongxian Liao, Xiaoyu Li, Chunying Zhang, Bihan Huang, Yingping Cao, Jiadi Chen
Publikováno v:
Immunobiology, Vol 229, Iss 6, Pp 152856- (2024)
Background: Our previous research has shown that LKB1 in amniotic mesenchymal stem cells (MSCs) serves as a vital regulator of regulatory T cell differentiation and T cell proliferation, which may have a similar role in bone marrow MSCs (BMMSCs). The
Externí odkaz:
https://doaj.org/article/805313696549484fa4fbaad09113015e
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundThe prognostic value and immune significance of T-cell proliferation regulators (TCRs) in hepatocellular carcinoma (HCC) have not been previously reported. This study aimed to develop a new prognostic model based on TCRs in patients with HC
Externí odkaz:
https://doaj.org/article/a5ef1b40524640929294a639265d2c07
Autor:
Xiangxiong Deng, Su Zhang, Quan Qing, Pengfei Wang, Haiyang Ma, Qinghua Ma, Weixiang Zhao, Hanjing Tang, Min Lu
Publikováno v:
Biochemistry and Biophysics Reports, Vol 39, Iss , Pp 101739- (2024)
Mesenchymal stem cells (MSCs) have tremendous potential in cell therapy and regenerative medicine. The placenta-derived MSCs (PMSCs) are becoming favorable sources as they are ethically preferable and rich in MSCs. Although several subgroups of PMSCs
Externí odkaz:
https://doaj.org/article/16df5cd5652b408694d30f1b569f4879
Autor:
Wanjin Jiang, Qi Yang, Xiaonan Yang, Ruijia Gan, Hongting Hua, Zhimin Ding, Dongyu Si, Xinbei Zhu, Xu Wang, Huabing Zhang, Chaobing Gao
Publikováno v:
Heliyon, Vol 10, Iss 14, Pp e34221- (2024)
Background: Thirty-three synthetic driver genes of T-cell proliferation have recently been identified through genome-scale screening. However, the tumor microenvironment (TME) cell infiltration, prognosis, and response to immunotherapy mediated by mu
Externí odkaz:
https://doaj.org/article/1151bf65dc10402b834d5f8598eacb6c
Autor:
Robin E. Walsh, Angela Nix, Chloé Ackaert, Aurélie Mazy, Jana Schockaert, Sofie Pattyn, Laurent Malherbe
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
T-cell dependent antibody responses to biotherapeutics remain a challenge to the optimal clinical application of biotherapeutics because of their capacity to impair drug efficacy and their potential to cause safety issues. To minimize this clinical i
Externí odkaz:
https://doaj.org/article/187dcf06803947fba4abb18ce530283f
Autor:
Xiaodi Liu, Qi Zhang, Yixia Liang, Shiyu Xiong, Yan Cai, Jincheng Cao, Yanni Xu, Xiaolin Xu, Ye Wu, Qiang Lu, Xiaoding Xu, Baoming Luo
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 12, Pp 5048-5059 (2023)
T cell infiltration and proliferation in tumor tissues are the main factors that significantly affect the therapeutic outcomes of cancer immunotherapy. Emerging evidence has shown that interferon-gamma (IFNγ) could enhance CXCL9 secretion from macro
Externí odkaz:
https://doaj.org/article/5c85d921d6d0445da6472fbb3838f530
Autor:
Dedeepya Pasupuleti, Priyal Bagwe, Amarae Ferguson, Mohammad N. Uddin, Martin J. D’Souza, Susu M. Zughaier
Publikováno v:
Vaccines, Vol 12, Iss 9, p 1049 (2024)
Inducing T lymphocyte (T-cell) activation and proliferation with specificity against a pathogen is crucial in vaccine formulation. Assessing vaccine candidates’ ability to induce T-cell proliferation helps optimize formulation for its safety, immun
Externí odkaz:
https://doaj.org/article/3b27ddeff29a4fdcb2c9b80a1c7a0363
Publikováno v:
Heliyon, Vol 9, Iss 11, Pp e21329- (2023)
T cell proliferation regulators (Tcprs), which are positive regulators that promote T cell function, have made great contributions to the development of therapies to improve T cell function. CAR (chimeric antigen receptor) -T cell therapy, a type of
Externí odkaz:
https://doaj.org/article/aee40795a5ab4f56a9130a5204179f53
Autor:
Qian Yang, Michael Patrick, Jian Lu, Joseph Chen, Yongqing Zhang, Humza Hemani, Elin Lehrmann, Supriyo De, Nan-ping Weng
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
T cell activation is a tightly controlled process involving both positive and negative regulators. The precise mechanisms governing the negative regulators in T cell proliferation remain incompletely understood. Here, we report that homeodomain-only
Externí odkaz:
https://doaj.org/article/d48f124f5e504222a3d352cb63036beb