Zobrazeno 1 - 10
of 3 654
pro vyhledávání: '"t-cell development"'
Autor:
Imtissal Krayem, Srdjan Grusanovic, Iris Duric, Nataliia Pavliuchenko, Petr Danek, Simon Borna, Jarmila Sekeresova Kralova, Tereza Skopcova, Jana Pokorna, Meritxell Alberich-Jorda, Tomas Brdicka
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
WW domain binding protein 1-like (WBP1L), also known as outcome predictor of acute leukemia 1 (OPAL1), is a transmembrane adaptor protein, expression of which was shown to correlate with ETV6-RUNX1 translocation and favorable prognosis in childhood l
Externí odkaz:
https://doaj.org/article/12e8f8773e8a424cacafe4196414d790
Autor:
Daniel G. Pellicci, Naeimeh Tavakolinia, Louis Perriman, Stuart P. Berzins, Christopher Menne
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Invariant natural killer T (iNKT) cells are a subset of lipid-reactive, unconventional T cells that have anti-tumor properties that make them a promising target for cancer immunotherapy. Recent studies have deciphered the developmental pathway of hum
Externí odkaz:
https://doaj.org/article/c1de806c8b184af89096bcb32a7a2ebc
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The thymus plays a pivotal role in generating a highly-diverse repertoire of T lymphocytes while preventing autoimmunity. Thymus seeding progenitors (TSPs) are a heterogeneous group of multipotent progenitors that migrate to the thymus via CCR7 and C
Externí odkaz:
https://doaj.org/article/8d273646020b4885b082d6e15a5a9c55
Autor:
Chan-Su Park, Jian Guan, Peter Rhee, Federico Gonzalez, Hee-sung Lee, Ji-hyun Park, Laurent Coscoy, Ellen A Robey, Nilabh Shastri, Scheherazade Sadegh-Nasseri
Publikováno v:
eLife, Vol 13 (2024)
The fate of developing T cells is determined by the strength of T cell receptor (TCR) signal they receive in the thymus. This process is finely regulated through the tuning of positive and negative regulators in thymocytes. The Family with sequence s
Externí odkaz:
https://doaj.org/article/5dac43e64dda4b1c805566d173e337bf
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Backgroud: Thymic atrophy marks the onset of immune aging, precipitating developmental anomalies in T cells. Numerous clinical and preclinical investigations have underscored the regulatory role of Ganoderma lucidum spores (GLS) in T cell development
Externí odkaz:
https://doaj.org/article/f972fae750834996954fae4c9e66a52c
Autor:
Yi Wang, Mark M. W. Chong
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
T cells express an enormous repertoire of T cell receptors, enabling them to recognize any potential antigen. This large repertoire undergoes stringent selections in the thymus, where receptors that react to self- or non-danger-associated- antigens a
Externí odkaz:
https://doaj.org/article/78c64727534f4282a80837fc465ff291
Autor:
Emi Ito, Sho Yamasaki
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Mucosal-associated invariant T (MAIT) cells are a major subset of innate-like T cells that function at the interface between innate and acquired immunity. MAIT cells recognize vitamin B2-related metabolites produced by microbes, through semi-invarian
Externí odkaz:
https://doaj.org/article/36d232c4016f4adcb285cb1e29fc6fde
Autor:
Michael Schmidt, Alexandra T. Linder, Marina Korn, Nick Schellenberg, Sarah J. Meyer, Falk Nimmerjahn, Anja Werner, Markus Abeln, Rita Gerardy-Schahn, Anja K. Münster-Kühnel, Lars Nitschke
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Sialic acids are found as terminal sugars on glycan structures on cellular surfaces. T cells carry these sialoglycans abundantly, and they are thought to serve multiple functions in cell adhesion, cell migration, and protection from complement attack
Externí odkaz:
https://doaj.org/article/8c5b3ce0d2684371a533192aaf40fe7f
Autor:
Hui Yu, Wenyong Yang, Min Cao, Qingqiang Lei, Renbin Yuan, He Xu, Yuqian Cui, Xuerui Chen, Xu Su, Hui Zhuo, Liangbin Lin
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
T cells play critical role in multiple immune processes including antigen response, tumor immunity, inflammation, self-tolerance maintenance and autoimmune diseases et. Fetal liver or bone marrow-derived thymus-seeding progenitors (TSPs) settle in th
Externí odkaz:
https://doaj.org/article/968089df13604ea285e4de2c485dc9a8
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionThe development and migration of T cells in the thymus and peripheral tissues are crucial for maintaining adaptive immunity in mammals. However, the regulatory mechanisms underlying T cell development and thymocyte identity formation in p
Externí odkaz:
https://doaj.org/article/cb6d0e1b8bb34ee9ae1e2491fc45510d