Zobrazeno 1 - 8
of 8
pro vyhledávání: '"t-cell bispecifics"'
Autor:
Maria Ochoa de Olza
Publikováno v:
eLife, Vol 10 (2021)
Organ-on-chip approaches could help researchers to better predict the toxicity of cancer immunotherapy drugs.
Externí odkaz:
https://doaj.org/article/6cdc0f1a682d41edb02d66a6e59710bb
Autor:
S Jordan Kerns, Chaitra Belgur, Debora Petropolis, Marianne Kanellias, Riccardo Barrile, Johannes Sam, Tina Weinzierl, Tanja Fauti, Anne Freimoser-Grundschober, Jan Eckmann, Carina Hage, Martina Geiger, Patrick Ray Ng, William Tien-Street, Dimitris V Manatakis, Virginie Micallef, Regine Gerard, Michael Bscheider, Ekaterina Breous-Nystrom, Anneliese Schneider, Anna Maria Giusti, Cristina Bertinetti-Lapatki, Heather Shannon Grant, Adrian B Roth, Geraldine A Hamilton, Thomas Singer, Katia Karalis, Annie Moisan, Peter Bruenker, Christian Klein, Marina Bacac, Nikolce Gjorevski, Lauriane Cabon
Publikováno v:
eLife, Vol 10 (2021)
Traditional drug safety assessment often fails to predict complications in humans, especially when the drug targets the immune system. Here, we show the unprecedented capability of two human Organs-on-Chips to evaluate the safety profile of T-cell bi
Externí odkaz:
https://doaj.org/article/65e3b07242e4472a8bccea9ce9f5ca1b
Autor:
Miro Julian Eigenmann, Tine Veronica Karlsen, Marek Wagner, Olav Tenstad, Tina Weinzierl, Tanja Fauti, Hans Peter Grimm, Trude Skogstrand, Christian Klein, Johannes Sam, Pablo Umana, Marina Bacac, Helge Wiig, Antje-Christine Walz
Publikováno v:
Pharmaceutics, Vol 13, Iss 12, p 2105 (2021)
The goal of this study is to investigate the pharmacokinetics in plasma and tumour interstitial fluid of two T-cell bispecifics (TCBs) with different binding affinities to the tumour target and to assess the subsequent cytokine release in a tumour-be
Externí odkaz:
https://doaj.org/article/a979047dc57b4cbf83485bdec1ad1621
Akademický článek
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Autor:
Katia Karalis, Anneliese Schneider, Riccardo Barrile, Annie Moisan, Peter Bruenker, William Tien-Street, Michael Bscheider, Patrick Ray Ng, Régine Gérard, Tanja Fauti, Anna Maria Giusti, Debora B. Petropolis, Ekaterina Breous-Nystrom, Marina Bacac, Johannes Sam, Thomas Singer, Adrian Roth, Nikolce Gjorevski, Tina Weinzierl, Virginie Micallef, Lauriane Cabon, Dimitris V. Manatakis, Carina Hage, Cristina Bertinetti-Lapatki, Jan Eckmann, Geraldine A. Hamilton, Christian Klein, S. Jordan Kerns, Chaitra Belgur, Marianne Kanellias, Anne Freimoser-Grundschober, Heather Shannon Grant, Martina Geiger
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Traditional drug safety assessment often fails to predict complications in humans, especially when the drug targets the immune system. Here, we show the unprecedented capability of two Organs-on-Chips to evaluate the safety profile of T-cell bispecif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca0bc505b8f7bce39068eca295b02de7
https://pubmed.ncbi.nlm.nih.gov/34558412
https://pubmed.ncbi.nlm.nih.gov/34558412
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Ochoa de Olza M; Lausanne University Hospital, Lausanne, Switzerland.
Publikováno v:
ELife [Elife] 2021 Sep 24; Vol. 10. Date of Electronic Publication: 2021 Sep 24.
Autor:
Kerns SJ; Emulate Inc, Boston, United States., Belgur C; Emulate Inc, Boston, United States., Petropolis D; Emulate Inc, Boston, United States., Kanellias M; Emulate Inc, Boston, United States., Barrile R; Emulate Inc, Boston, United States.; Department of Biomedical Engineering, University of Cincinnati, Cincinnati, United States., Sam J; Roche Pharma Research & Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland., Weinzierl T; Roche Pharma Research & Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland., Fauti T; Roche Pharma Research & Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland., Freimoser-Grundschober A; Roche Pharma Research & Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland., Eckmann J; Roche Pharma Research & Early Development, Roche Innovation Center Munich, Penzberg, Germany., Hage C; Roche Pharma Research & Early Development, Roche Innovation Center Munich, Penzberg, Germany., Geiger M; Roche Pharma Research & Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland., Ng PR; Emulate Inc, Boston, United States., Tien-Street W; Emulate Inc, Boston, United States., Manatakis DV; Emulate Inc, Boston, United States., Micallef V; Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland., Gerard R; Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland., Bscheider M; Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland., Breous-Nystrom E; Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland., Schneider A; Roche Pharma Research & Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland., Giusti AM; Roche Pharma Research & Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland., Bertinetti-Lapatki C; Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland., Grant HS; Emulate Inc, Boston, United States., Roth AB; Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland., Hamilton GA; Emulate Inc, Boston, United States., Singer T; Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland., Karalis K; Emulate Inc, Boston, United States., Moisan A; Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland., Bruenker P; Roche Pharma Research & Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland., Klein C; Roche Pharma Research & Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland., Bacac M; Roche Pharma Research & Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland., Gjorevski N; Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland., Cabon L; Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland.
Publikováno v:
ELife [Elife] 2021 Aug 11; Vol. 10. Date of Electronic Publication: 2021 Aug 11.