Predicting Antigen‐Specificities of Orphan T Cell Receptors from Cancer Patients with TCRpcDist

Autor: Marta A. S. Perez, Johanna Chiffelle, Sara Bobisse, Francesca Mayol‐Rullan, Marine Bugnon, Maiia E. Bragina, Marion Arnaud, Christophe Sauvage, David Barras, Denarda Dangaj Laniti, Florian Huber, Michal Bassani‐Sternberg, George Coukos, Alexandre Harari, Vincent Zoete

Publikováno v: Advanced Science, Vol 11, Iss 40, Pp n/a-n/a (2024)

Abstract Approaches to analyze and cluster T‐cell receptor (TCR) repertoires to reflect antigen specificity are critical for the diagnosis and prognosis of immune‐related diseases and the development of personalized therapies. Sequence‐based ap

Externí odkaz: https://doaj.org/article/7c1d5f76a223445b9ae15faddaab978c

TMB and TCR Are Correlated Indicators Predictive of the Efficacy of Neoadjuvant Chemotherapy in Breast Cancer

Autor: Hongling Liang, Jia Huang, Xiang Ao, Weibang Guo, Yu Chen, Danxia Lu, Zhiyi Lv, Xiaojun Tan, Weixing He, Ming Jiang, Haoming Xia, Yongtao Zhan, Weiling Guo, Zhiqing Ye, Lei Jiao, Jie Ma, Changxi Wang, Hongsheng Li, Xuchao Zhang, Jianqing Huang

Publikováno v: Frontiers in Oncology, Vol 11 (2021)

Immune characteristics were reported correlated to benefit neoadjuvant chemotherapy (NAC) in breast cancer, yet integration of comprehensive genomic alterations and T-cell receptors (TCR) to predict efficacy of NAC needs further investigation. This s

Externí odkaz: https://doaj.org/article/6fa9e62c9e264a969d91e60e863a2cac

Séléction de CD8 non conventionnel au cours de la thymopoïèse humaine

Autor: Quiniou, Valentin

Publikováno v: Immunology. Sorbonne Université, 2020. English. ⟨NNT : 2020SORUS430⟩

Specificity is the hallmark of the adaptive immune response. For T cells, specificity is mediated by T cell receptors (TCRs), which interact with peptides presented by major histocompatibility complex molecules through their complementary-determining

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1398::83a96dbe79fad8c780666add89284fce
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Predicting Antigen-Specificities of Orphan T Cell Receptors from Cancer Patients with TCRpcDist.

Autor: Perez MAS; Department of Oncology, Ludwig Institute for Cancer Research, Lausanne Branch, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Agora Cancer Research Center, Lausanne, CH-1005, Switzerland.; Molecular Modeling Group, SIB Swiss Institute of Bioinformatics, University of Lausanne, Quartier UNIL-Sorge, Bâtiment Amphipole, Lausanne, CH-1015, Switzerland., Chiffelle J; Department of Oncology, Ludwig Institute for Cancer Research, Lausanne Branch, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Agora Cancer Research Center, Lausanne, CH-1005, Switzerland.; Center for Cell Therapy, CHUV-Ludwig Institute, Lausanne, CH-1011, Switzerland., Bobisse S; Department of Oncology, Ludwig Institute for Cancer Research, Lausanne Branch, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Agora Cancer Research Center, Lausanne, CH-1005, Switzerland.; Center for Cell Therapy, CHUV-Ludwig Institute, Lausanne, CH-1011, Switzerland., Mayol-Rullan F; Department of Oncology, Ludwig Institute for Cancer Research, Lausanne Branch, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Agora Cancer Research Center, Lausanne, CH-1005, Switzerland.; Molecular Modeling Group, SIB Swiss Institute of Bioinformatics, University of Lausanne, Quartier UNIL-Sorge, Bâtiment Amphipole, Lausanne, CH-1015, Switzerland., Bugnon M; Department of Oncology, Ludwig Institute for Cancer Research, Lausanne Branch, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Agora Cancer Research Center, Lausanne, CH-1005, Switzerland.; Molecular Modeling Group, SIB Swiss Institute of Bioinformatics, University of Lausanne, Quartier UNIL-Sorge, Bâtiment Amphipole, Lausanne, CH-1015, Switzerland., Bragina ME; Department of Oncology, Ludwig Institute for Cancer Research, Lausanne Branch, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Agora Cancer Research Center, Lausanne, CH-1005, Switzerland.; Molecular Modeling Group, SIB Swiss Institute of Bioinformatics, University of Lausanne, Quartier UNIL-Sorge, Bâtiment Amphipole, Lausanne, CH-1015, Switzerland., Arnaud M; Department of Oncology, Ludwig Institute for Cancer Research, Lausanne Branch, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Agora Cancer Research Center, Lausanne, CH-1005, Switzerland.; Center for Cell Therapy, CHUV-Ludwig Institute, Lausanne, CH-1011, Switzerland., Sauvage C; Department of Oncology, Ludwig Institute for Cancer Research, Lausanne Branch, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Agora Cancer Research Center, Lausanne, CH-1005, Switzerland.; Center for Cell Therapy, CHUV-Ludwig Institute, Lausanne, CH-1011, Switzerland., Barras D; Department of Oncology, Ludwig Institute for Cancer Research, Lausanne Branch, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Agora Cancer Research Center, Lausanne, CH-1005, Switzerland.; Center for Cell Therapy, CHUV-Ludwig Institute, Lausanne, CH-1011, Switzerland., Laniti DD; Department of Oncology, Ludwig Institute for Cancer Research, Lausanne Branch, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Agora Cancer Research Center, Lausanne, CH-1005, Switzerland.; Center for Cell Therapy, CHUV-Ludwig Institute, Lausanne, CH-1011, Switzerland., Huber F; Department of Oncology, Ludwig Institute for Cancer Research, Lausanne Branch, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Agora Cancer Research Center, Lausanne, CH-1005, Switzerland.; Center for Cell Therapy, CHUV-Ludwig Institute, Lausanne, CH-1011, Switzerland., Bassani-Sternberg M; Department of Oncology, Ludwig Institute for Cancer Research, Lausanne Branch, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Agora Cancer Research Center, Lausanne, CH-1005, Switzerland.; Center for Cell Therapy, CHUV-Ludwig Institute, Lausanne, CH-1011, Switzerland., Coukos G; Department of Oncology, Ludwig Institute for Cancer Research, Lausanne Branch, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Agora Cancer Research Center, Lausanne, CH-1005, Switzerland.; Center for Cell Therapy, CHUV-Ludwig Institute, Lausanne, CH-1011, Switzerland.; Department of Oncology, Immuno-Oncology Service, Lausanne University Hospital, Lausanne, CH-1011, Switzerland., Harari A; Department of Oncology, Ludwig Institute for Cancer Research, Lausanne Branch, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Agora Cancer Research Center, Lausanne, CH-1005, Switzerland.; Center for Cell Therapy, CHUV-Ludwig Institute, Lausanne, CH-1011, Switzerland., Zoete V; Department of Oncology, Ludwig Institute for Cancer Research, Lausanne Branch, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Agora Cancer Research Center, Lausanne, CH-1005, Switzerland.; Molecular Modeling Group, SIB Swiss Institute of Bioinformatics, University of Lausanne, Quartier UNIL-Sorge, Bâtiment Amphipole, Lausanne, CH-1015, Switzerland.

Publikováno v: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Oct; Vol. 11 (40), pp. e2405949. Date of Electronic Publication: 2024 Aug 19.