Exploring the therapeutic potential of precision T-Cell Receptors (TCRs) in targeting KRAS G12D cancer through in vitro development.

Autor: Zheng W; Sino-German Biomedical Center, National '111' Center for Cellular Regulation and Molecular Pharmaceutics, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education of China & Hubei Province), Hubei University of Technology, Wuhan, 430068, China., Jiang D; Center of Research & Development, Beijing CorreGene Biotechnology Co., Ltd., Beijing, 102206, China., Chen S; Sino-German Biomedical Center, National '111' Center for Cellular Regulation and Molecular Pharmaceutics, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education of China & Hubei Province), Hubei University of Technology, Wuhan, 430068, China., Wu M; Sino-German Biomedical Center, National '111' Center for Cellular Regulation and Molecular Pharmaceutics, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education of China & Hubei Province), Hubei University of Technology, Wuhan, 430068, China., Yan B; Center of Research & Development, Beijing CorreGene Biotechnology Co., Ltd., Beijing, 102206, China., Zhai J; Center of Research & Development, Beijing CorreGene Biotechnology Co., Ltd., Beijing, 102206, China., Shi Y; Center of Research & Development, Beijing CorreGene Biotechnology Co., Ltd., Beijing, 102206, China., Xie B; Sino-German Biomedical Center, National '111' Center for Cellular Regulation and Molecular Pharmaceutics, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education of China & Hubei Province), Hubei University of Technology, Wuhan, 430068, China., Xie X; Center of Research & Development, Beijing CorreGene Biotechnology Co., Ltd., Beijing, 102206, China., Hu K; Sino-German Biomedical Center, National '111' Center for Cellular Regulation and Molecular Pharmaceutics, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education of China & Hubei Province), Hubei University of Technology, Wuhan, 430068, China., Ma W; Department of Medicine, Sanford Stem Cell Institute and Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.

Publikováno v: Oncology research [Oncol Res] 2024 Nov 13; Vol. 32 (12), pp. 1837-1850. Date of Electronic Publication: 2024 Nov 13 (Print Publication: 2024).

Public T-Cell Receptors (TCRs) Revisited by Analysis of the Magnitude of Identical and Highly-Similar TCRs in Virus-Specific T-Cell Repertoires of Healthy Individuals

Autor: Wesley Huisman, Lois Hageman, Didier A. T. Leboux, Alexandra Khmelevskaya, Grigory A. Efimov, Marthe C. J. Roex, Derk Amsen, J. H. Frederik Falkenburg, Inge Jedema

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Since multiple different T-cell receptor (TCR) sequences can bind to the same peptide-MHC combination and the number of TCR-sequences that can theoretically be generated even exceeds the number of T cells in a human body, the likelihood that many pub

Externí odkaz: https://doaj.org/article/8c317c5f5ec342cead55f08d7667e8af

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Predicting Antigen‐Specificities of Orphan T Cell Receptors from Cancer Patients with TCRpcDist

Autor: Marta A. S. Perez, Johanna Chiffelle, Sara Bobisse, Francesca Mayol‐Rullan, Marine Bugnon, Maiia E. Bragina, Marion Arnaud, Christophe Sauvage, David Barras, Denarda Dangaj Laniti, Florian Huber, Michal Bassani‐Sternberg, George Coukos, Alexandre Harari, Vincent Zoete

Publikováno v: Advanced Science, Vol 11, Iss 40, Pp n/a-n/a (2024)

Abstract Approaches to analyze and cluster T‐cell receptor (TCR) repertoires to reflect antigen specificity are critical for the diagnosis and prognosis of immune‐related diseases and the development of personalized therapies. Sequence‐based ap

Externí odkaz: https://doaj.org/article/7c1d5f76a223445b9ae15faddaab978c

Signaling from T cell receptors (TCRs) and chimeric antigen receptors (CARs) on T cells

Autor: Ling Wu, Qianru Wei, Joanna Brzostek, Nicholas R. J. Gascoigne

Publikováno v: Cell Mol Immunol

T cells react to foreign or self-antigens through T cell receptor (TCR) signaling. Several decades of research have delineated the mechanism of TCR signal transduction and its impact on T cell performance. This knowledge provides the foundation for c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1a05bfee27ae79caf4ccbab03c28a22
https://doi.org/10.1038/s41423-020-0470-3