Systems glycobiology for discovering drug targets, biomarkers, and rational designs for glyco-immunotherapy

Autor: Austin W. T. Chiang, Hratch M. Baghdassarian, Benjamin P. Kellman, Bokan Bao, James T. Sorrentino, Chenguang Liang, Chih-Chung Kuo, Helen O. Masson, Nathan E. Lewis

Publikováno v: Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-15 (2021)

Abstract Cancer immunotherapy has revolutionized treatment and led to an unprecedented wave of immuno-oncology research during the past two decades. In 2018, two pioneer immunotherapy innovators, Tasuku Honjo and James P. Allison, were awarded the No

Externí odkaz: https://doaj.org/article/1effcf77853041a2abacd227d52e50a8

A consensus-based and readable extension of Linear Code for Reaction Rules (LiCoRR)

Autor: Benjamin P. Kellman, Yujie Zhang, Emma Logomasini, Eric Meinhardt, Karla P. Godinez-Macias, Austin W. T. Chiang, James T. Sorrentino, Chenguang Liang, Bokan Bao, Yusen Zhou, Sachiko Akase, Isami Sogabe, Thukaa Kouka, Elizabeth A. Winzeler, Iain B. H. Wilson, Matthew P. Campbell, Sriram Neelamegham, Frederick J. Krambeck, Kiyoko F. Aoki-Kinoshita, Nathan E. Lewis

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 2645-2662 (2020)

Systems glycobiology aims to provide models and analysis tools that account for the biosynthesis, regulation, and interactions with glycoconjugates. To facilitate these methods, there is a need for a clear glycan representation accessible to both com

Externí odkaz: https://doaj.org/article/d2673eab9e7b4440a013dfc392b24604

A Markov model of glycosylation elucidates isozyme specificity and glycosyltransferase interactions for glycoengineering

Autor: Johnny Arnsdorf, Chenguang Liang, Bjørn G. Voldborg, Benjamin P. Kellman, Bokan Bao, Anders Holmgaard Hansen, Nathan E. Lewis, James T. Sorrentino, Austin W. T. Chiang, Sanne Schoffelen

Publikováno v: Current Research in Biotechnology, Vol 2, Iss, Pp 22-36 (2020)
Liang, C, Chiang, A W T, Hansen, A H, Arnsdorf, J, Schoffelen, S, Sorrentino, J T, Kellman, B P, Bao, B, Voldborg, B G & Lewis, N E 2020, ' A Markov model of glycosylation elucidates isozyme specificity and glycosyltransferase interactions for glycoengineering ', Current Research in Biotechnology, vol. 2, pp. 22-36 . https://doi.org/10.1016/j.crbiot.2020.01.001
Curr Res Biotechnol

Glycosylated biopharmaceuticals are important in the global pharmaceutical market. Despite the importance of their glycan structures, our limited knowledge of the glycosylation machinery still hinders controllability of this critical quality attribut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8804b7be972f26057385ebe88f695122
http://www.sciencedirect.com/science/article/pii/S2590262820300010

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Systems glycobiology for discovering drug targets, biomarkers, and rational designs for glyco-immunotherapy

Autor: Chih-Chung Kuo, Nathan E. Lewis, Chenguang Liang, Benjamin P. Kellman, Bokan Bao, Hratch M. Baghdassarian, Helen O. Masson, James T. Sorrentino, Austin W. T. Chiang

Publikováno v: Journal of Biomedical Science
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-15 (2021)
Chiang, A W T, Baghdassarian, H M, Kellman, B P, Bao, B, Sorrentino, J T, Liang, C, Kuo, C C, Masson, H O & Lewis, N E 2021, ' Systems glycobiology for discovering drug targets, biomarkers, and rational designs for glyco-immunotherapy ', Journal of Biomedical Science, vol. 28, no. 1, 50 . https://doi.org/10.1186/s12929-021-00746-2

Cancer immunotherapy has revolutionized treatment and led to an unprecedented wave of immuno-oncology research during the past two decades. In 2018, two pioneer immunotherapy innovators, Tasuku Honjo and James P. Allison, were awarded the Nobel Prize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::825717e99248f3cdd1eee82fb7b286a5
https://doi.org/10.1186/s12929-021-00746-2