Zobrazeno 1 - 10
of 951
pro vyhledávání: '"systems genetics"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Externí odkaz:
https://doaj.org/article/2c15159eff4c49449ec7af496829afce
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Parasympathetic activation in the anterior eye segment regulates various physiological functions. This process, mediated by muscarinic acetylcholine receptors, also impacts intraocular pressure (IOP) through the trabecular meshwork. While FDA-approve
Externí odkaz:
https://doaj.org/article/5641b9c19b2a4bae881733e7cd73dbe0
Autor:
Wentao Zhang, Erin E. Higgins, Stephen J. Robinson, Wayne E. Clarke, Kerry Boyle, Andrew G. Sharpe, Pierre R. Fobert, Isobel A. P. Parkin
Publikováno v:
Frontiers in Plant Science, Vol 15 (2024)
Seed quality traits of oilseed rape, Brassica napus (B. napus), exhibit quantitative inheritance determined by its genetic makeup and the environment via the mediation of a complex genetic architecture of hundreds to thousands of genes. Thus, instead
Externí odkaz:
https://doaj.org/article/2eb6f47eba4c4ed4982857df6b758498
Autor:
Jiaxin Yang, Sikta Das Adhikari, Hao Wang, Binbin Huang, Wenjie Qi, Yuehua Cui, Jianrong Wang
Publikováno v:
Frontiers in Systems Biology, Vol 4 (2024)
Deciphering the functional effects of noncoding genetic variants stands as a fundamental challenge in human genetics. Traditional approaches, such as Genome-Wide Association Studies (GWAS), Transcriptome-Wide Association Studies (TWAS), and Quantitat
Externí odkaz:
https://doaj.org/article/eab66063d39a42958ecd552f4f14aa78
Autor:
Mingqi Zhou, Ian Tamburini, Cassandra Van, Jeffrey Molendijk, Christy M Nguyen, Ivan Yao-Yi Chang, Casey Johnson, Leandro M Velez, Youngseo Cheon, Reichelle Yeo, Hosung Bae, Johnny Le, Natalie Larson, Ron Pulido, Carlos HV Nascimento-Filho, Cholsoon Jang, Ivan Marazzi, Jamie Justice, Nicholas Pannunzio, Andrea L Hevener, Lauren Sparks, Erin E Kershaw, Dequina Nicholas, Benjamin L Parker, Selma Masri, Marcus M Seldin
Publikováno v:
eLife, Vol 12 (2024)
Inter-organ communication is a vital process to maintain physiologic homeostasis, and its dysregulation contributes to many human diseases. Given that circulating bioactive factors are stable in serum, occur naturally, and are easily assayed from blo
Externí odkaz:
https://doaj.org/article/b0b0c3945a2343e1a77c073ec88b5282
Autor:
Hooman Allayee, Charles R Farber, Marcus M Seldin, Evan Graehl Williams, David E James, Aldons J Lusis
Publikováno v:
eLife, Vol 12 (2023)
Quantitative traits are often complex because of the contribution of many loci, with further complexity added by environmental factors. In medical research, systems genetics is a powerful approach for the study of complex traits, as it integrates int
Externí odkaz:
https://doaj.org/article/02a567f1967b4dd08c0627ee97eba3b3
Autor:
Xiaoxu Li, Jean-David Morel, Giorgia Benegiamo, Johanne Poisson, Alexis Bachmann, Alexis Rapin, Jonathan Sulc, Evan Williams, Alessia Perino, Kristina Schoonjans, Maroun Bou Sleiman, Johan Auwerx
Publikováno v:
eLife, Vol 12 (2023)
Inflammatory gut disorders, including inflammatory bowel disease (IBD), can be impacted by dietary, environmental, and genetic factors. While the incidence of IBD is increasing worldwide, we still lack a complete understanding of the gene-by-environm
Externí odkaz:
https://doaj.org/article/8be70e9354e742299013c37a8d97b8b1
Autor:
Karthickeyan Chella Krishnan
Publikováno v:
eLife, Vol 12 (2023)
Gene expression profiling of a diverse mouse population helps to decipher how a fat-rich diet contributes to inflammatory bowel disease.
Externí odkaz:
https://doaj.org/article/81d3fcd0593e4ea5b3ea7898a299c2d2
Autor:
Simon T. Hui, Lili Gong, Chantle Swichkow, Montgomery Blencowe, Dorota Kaminska, Graciel Diamante, Calvin Pan, Meet Dalsania, Samuel W. French, Clara E. Magyar, Päivi Pajukanta, Jussi Pihlajamäki, Kristina I. Boström, Xia Yang, Aldons J. Lusis
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 6, Pp 943-960 (2023)
Background & Aims: Nonalcoholic steatohepatitis (NASH) is a complex disease involving both genetic and environmental factors in its onset and progression. We analyzed NASH phenotypes in a genetically diverse cohort of mice, the Hybrid Mouse Diversity
Externí odkaz:
https://doaj.org/article/17f948e14a694036a2a9724de594eb98