Zobrazeno 1 - 10
of 489
pro vyhledávání: '"system xc"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Diabetic wounds are a severe complication of diabetes, characterized by persistent, non-healing ulcers due to disrupted wound-healing mechanisms in a hyperglycemic environment. Key factors in the pathogenesis of these chronic wounds include unresolve
Externí odkaz:
https://doaj.org/article/fb692f37cd0e4e97a77bce87a007a552
Autor:
Yun-Jeong Kim, Bumhee Lim, Seo Young Kim, Yoon-Ze Shin, Nayoung Yu, Eun-Kyung Shin, Jae-Eon Lee, Yong Hyun Jeon, Dae-Duk Kim, Jeeyeon Lee, Hyuk-Jin Cha
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 176, Iss , Pp 116758- (2024)
Sorafenib (BAY 43–9006) was developed as a multi-kinase inhibitor to treat advanced renal cell, hepatocellular, and thyroid cancers. The cytotoxic effect of sorafenib on cancer cells results from not only inhibiting the MEK/ERK signaling pathway (t
Externí odkaz:
https://doaj.org/article/f9be2ef7a3bb412988718f210627affe
Autor:
Lina Feng, Jingyi Sun, Ling Xia, Qiang Shi, Yajun Hou, Lili Zhang, Mingquan Li, Cundong Fan, Baoliang Sun
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 8, Pp 1741-1750 (2024)
Regulated cell death is a genetically determined form of programmed cell death that commonly occurs during the development of living organisms. This process plays a crucial role in modulating homeostasis and is evolutionarily conserved across a diver
Externí odkaz:
https://doaj.org/article/5741f14063a14ceeb39babef3681528b
Autor:
Mariusz P. Gajewski, Steven W. Barger
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-9 (2023)
Abstract Neuroinflammation appears to involve some degree of excitotoxicity promulgated by microglia, which release glutamate via the system xC − (SxC −) cystine-glutamate antiporter. With the aim of mitigating this source of neuronal stress and
Externí odkaz:
https://doaj.org/article/7fc56978c1a7400897c7fe545b616c1d
Autor:
Anna Koppin, Leah Chase
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 19, p 10271 (2024)
System xc−, the cystine/glutamate exchanger, is a membrane transporter that plays a critical role in the antioxidant response of cells. Recent work has shown that System xc− localizes to the plasma membrane during oxidative stress, allowing for i
Externí odkaz:
https://doaj.org/article/f1818c19dc3d4c888bc7cf5a81dc848b
Publikováno v:
Cells, Vol 13, Iss 18, p 1541 (2024)
Ferroptosis is an iron-dependent form of programmed cell death that is influenced by biological processes such as iron metabolism and senescence. As brain iron levels increase with aging, ferroptosis is also implicated in the development of age-relat
Externí odkaz:
https://doaj.org/article/c735cdeba7ad48b5889b333204c11ad6
Publikováno v:
Toxics, Vol 12, Iss 9, p 644 (2024)
Prolonged exposure to hydroquinone (HQ), a metabolite of benzene, can cause severe haematologic disorders in humans. However, the mechanism is still unclear. In the present study, we investigated whether HQ can induce haematological diseases through
Externí odkaz:
https://doaj.org/article/9cf19cc1aaf944c6958db928dc93444c
Autor:
Sisi Wang, Du Wu, Fangquan Wu, Hongxia Sun, Xinyu Wang, Hongbing Meng, Qingqing Lin, Keke Jin, Fangyan Wang
Publikováno v:
BMC Complementary Medicine and Therapies, Vol 23, Iss 1, Pp 1-12 (2023)
Abstract Background Ethanol-induced gastric mucosal lesions (EGML) is one of the most common digestive disorders for which current therapies have limited outcomes in clinical practice. Prevotella histicola (P. histicola) has shown probiotic efficacy
Externí odkaz:
https://doaj.org/article/8e6eed4362dc4c248c9527212c5e02cd
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 166, Iss , Pp 115415- (2023)
Iron, as an essential trace element for the organism, is vital for maintaining the organism's health. Excessive iron can promote reactive oxygen species (ROS) accumulation, thus damaging cells and tissues. Ferroptosis is a novel form of programmed ce
Externí odkaz:
https://doaj.org/article/737b01be14744a9b922ab11853463f56
Autor:
Lu-Yao Li, Qi Wang, Lu Deng, Zhen Lin, Jing-Jing Lin, Xin-Ye Wang, Tian-Yang Shen, Yi-Hui Zheng, Wei Lin, Pei-Jun Li, Xiao-Qin Fu, Zhen-Lang Lin
Publikováno v:
Neural Regeneration Research, Vol 18, Iss 3, Pp 568-576 (2023)
Recent studies have shown that chlorogenic acid (CGA), which is present in coffee, has protective effects on the nervous system. However, its role in neonatal hypoxic-ischemic brain injury remains unclear. In this study, we established a newborn mous
Externí odkaz:
https://doaj.org/article/702d0a940dca47c9b0bcaf1dbac8a664