Výsledky vyhledávání - "synuclein (-synuclein)"

Oleuropein derivatives from olive fruit extracts reduce α-synuclein fibrillation and oligomer toxicity

Autor: Gunna Christiansen, Daniel E. Otzen, Hossein Mohammad-Beigi, Hoda Eskandari, Cagla Sahin, Mehdi Hosseini-Mazinani, Alireza Amiri-Nowdijeh, Nicholas P. Schafer, Jane L. Ward, Charlotte Lomax, Ian M. Møller, Dina Morshedi, Farhang Aliakbari, Ahmed F. Tawfike

Publikováno v: Mohammad-Beigi, H, Aliakbari, F, Sahin, C, Lomax, C, Tawfike, A, Schafer, N P, Amiri-Nowdijeh, A, Eskandari, H, Møller, I M, Hosseini-Mazinani, M, Christiansen, G, Ward, J L, Morshedi, D & Otzen, D E 2019, ' Oleuropein derivatives from olive fruit extracts reduce α-synuclein fibrillation and oligomer toxicity ' The Journal of biological chemistry . https://doi.org/10.1074/jbc.RA118.005723
Mohammad-Beigi, H, Aliakbari, F, Sahin, C, Lomax, C, Tawfike, A, P. Schafer, N, Amiri-Nowdijeh, A, Eskandari, H, Møller, I M, Hosseini-Mazinani, M, Christiansen, G, Ward, J L, Morshedi, D & Otzen, D 2019, ' Oleuropein derivatives from olive fruit extracts reduce α-synuclein fibrillation and oligomer toxicity ', Journal of Biological Chemistry, vol. 294, no. 11, pp. 4215-4232 . https://doi.org/10.1074/jbc.RA118.005723

Aggregation of α-synuclein (αSN) is implicated in neuronal degeneration in Parkinson's disease and has prompted searches for natural compounds inhibiting αSN aggregation and reducing its tendency to form toxic oligomers. Oil from the olive tree (O

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a782b93d59484a9671c3d48dcb0a075
https://pure.au.dk/portal/da/publications/oleuropein-derivatives-from-olive-fruit-extracts-reduce-synuclein-fibrillation-and-oligomer-toxicity(3b145a21-d995-4833-825d-8ec555acb8df).html

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Methionine oxidation in -synuclein inhibits its propensity for ordered secondary structure

Autor: Erika Ponzini, Frank Sobott, Antonino Natalello, Rossana Rossi, Rita Grandori, Antonella De Palma, Lucilla Cerboni, Carlo Santambrogio, Pierluigi Mauri, Giuseppe Legname, Rani Moons, Joanna Narkiewicz, Albert Konijnenberg

Publikováno v: Journal of biological chemistry
The Journal of biological chemistry
Apr 5;294(14) (2019): 5657–5665. doi:10.1074/jbc.RA118.001907
info:cnr-pdr/source/autori:Erika Ponzini1, Antonella De Palma2, Lucilla Cerboni1, Antonino Natalello3, Rossana Rossi4, Rani Moons5, Albert Konijnenberg5, Joanna Narkiewicz6, Giuseppe Antonio Legname7, Frank Sobott8, Pierluigi Mauri4, Carlo Santambrogio1* and Rita Grandori9/titolo:Methionine oxidation in ?-synuclein inhibits its propensity for ordered secondary structure/doi:10.1074%2Fjbc.RA118.001907/rivista:The Journal of biological chemistry (Print)/anno:2019/pagina_da:5657/pagina_a:5665/intervallo_pagine:5657–5665/volume:Apr 5;294(14)
Journal of biological chemistry (Online) 294 (2019): 5657–5665. doi:10.1074/jbc.RA118.001907
info:cnr-pdr/source/autori:Ponzini E, De Palma A, Cerboni L, Natalello A, Rossi R, Moons R, Konijnenberg A, Narkiewicz J, Legname G, Sobott F, Mauri P, Santambrogio C, Grandori R./titolo:Methionine oxidation in ?-synuclein inhibits its propensity for ordered secondary structure/doi:10.1074%2Fjbc.RA118.001907/rivista:Journal of biological chemistry (Online)/anno:2019/pagina_da:5657/pagina_a:5665/intervallo_pagine:5657–5665/volume:294

alpha-Synuclein (AS) is an intrinsically disordered protein highly expressed in dopaminergic neurons. Its amyloid aggregates are the major component of Lewy bodies, a hallmark of Parkinson's disease (PD). AS is particularly exposed to oxidation of it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8415707babbd98a8f4da97e49c9f805f
http://hdl.handle.net/10281/270132

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Einzelmolekülbasierte Aggregationsanalyse von Alpha-Synuclein und Tau-Protein

Autor: Bader, Benedikt

Die Synucleinopathien sind eine Gruppe neurodegenerativer Erkrankungen, die durch pathologische Ablagerungen des Alpha Synucleins charakterisiert sind. Sie umfassen unter anderem den Morbus Parkinson, die Demenz mit Lewy-Körperchen, die multiple Sys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6ff2164c235e8fb3e5527c4bc9f5ce00

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