Zobrazeno 1 - 10
of 143
pro vyhledávání: '"synthetic mRNA"'
Autor:
Sonia Golombek, Thomas Hoffmann, Ludmilla Hann, Markus Mandler, Sabine Schmidhuber, Josefin Weber, Young-Tae Chang, Roman Mehling, Andrea Ladinig, Christian Knecht, Johanna Leyens, Christian Schlensak, Hans Peter Wendel, Achim Schneeberger, Meltem Avci-Adali
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 642-654 (2023)
Loss of elastin due to aging, disease, or injury can lead to impaired tissue function. In this study, de novo tropoelastin (TE) synthesis is investigated in vitro and in vivo using different TE-encoding synthetic mRNA variants after codon optimizatio
Externí odkaz:
https://doaj.org/article/fb35e12ee64a40e1bef0ae30f9a604f7
Autor:
Sonia Golombek, Isabelle Doll, Louisa Kaufmann, Mario Lescan, Christian Schlensak, Meltem Avci-Adali
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6599 (2024)
Aneurysms pose life-threatening risks due to the dilatation of the arteries and carry a high risk of rupture. Despite continuous research efforts, there are still no satisfactory or clinically effective pharmaceutical treatments for this condition. A
Externí odkaz:
https://doaj.org/article/b756614a529440ad8a3767524880115b
Autor:
Cheuk Yin Li, Zhenghua Liang, Yaxin Hu, Hongxia Zhang, Kharis Daniel Setiasabda, Jiawei Li, Shaohua Ma, Xiaojun Xia, Yi Kuang
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 30, Iss , Pp 300-310 (2022)
Synthetic mRNAs are rising rapidly as alternative therapeutic agents for delivery of proteins. However, the practical use of synthetic mRNAs has been restricted by their low cellular stability as well as poor protein production efficiency. The key ro
Externí odkaz:
https://doaj.org/article/f3a37484e6f24b7e9cc3bd27ec13a10e
Autor:
Hao Peng, Xingrong Guo, Jinjuan He, Chao Duan, Minghuan Yang, Xianghua Zhang, Li Zhang, Rui Fu, Bin Wang, Dekang Wang, Hu Chen, Mengying Xie, Ping Feng, Longjun Dai, Xiangjun Tang, Jie Luo
Publikováno v:
Molecular Therapy: Oncolytics, Vol 24, Iss , Pp 160-170 (2022)
Owing to messenger RNA's unique biological advantages, it has received increasing attention to be used as a therapeutic, known as mRNA-based gene therapy. It is critical to have an ideal strategy of mRNA gene therapy for glioma, which grows in a spec
Externí odkaz:
https://doaj.org/article/549dded9a50946e5807cf30e57d7bb1e
Autor:
Xiangjun Tang, Hao Peng, Pengfei Xu, Li Zhang, Rui Fu, Hanjun Tu, Xingrong Guo, Kuanming Huang, Junti Lu, Hu Chen, Zhiqiang Dong, Longjun Dai, Jie Luo, Qianxue Chen
Publikováno v:
Molecular Therapy: Oncolytics, Vol 24, Iss , Pp 707-718 (2022)
Glioblastoma (GBM) is characterized as having high molecular heterogeneity and complexity, which can be well revealed by genomic study. A truly effective treatment for GBM should flexibly address its heterogeneities, complexity, and strong drug resis
Externí odkaz:
https://doaj.org/article/bc16d7bcfc864c438b4ff42730ccf89c
Autor:
Qian Li, Yi Feng, Yingchao Xue, Xiping Zhan, Yi Fu, Gege Gui, Weiqiang Zhou, Jean-Philippe Richard, Arens Taga, Pan Li, Xiaobo Mao, Nicholas J. Maragakis, Mingyao Ying
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-18 (2022)
Abstract Background Spinal cord motor neurons (MNs) from human iPS cells (iPSCs) have wide applications in disease modeling and therapeutic development for amyotrophic lateral sclerosis (ALS) and other MN-associated neurodegenerative diseases. We nee
Externí odkaz:
https://doaj.org/article/70f0c66d888a47efbd6862aa632e9222
Akademický článek
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Akademický článek
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Publikováno v:
BioTechniques, Vol 69, Iss 4, Pp 281-288 (2020)
We present a method to synthesize mRNAs from synthetic DNA templates that produce biologically active proteins. To illustrate utility, we constructed five unique synthetic DNA templates, produced mRNAs and demonstrated biologic activity of their tran
Externí odkaz:
https://doaj.org/article/6cbccd87a45f401fa875c41b0b7e5d4a
Autor:
Denis Canjuga, Heidrun Steinle, Jana Mayer, Ann-Kristin Uhde, Gerd Klein, Hans Peter Wendel, Christian Schlensak, Meltem Avci-Adali
Publikováno v:
Pharmaceutics, Vol 14, Iss 6, p 1194 (2022)
Endothelial progenitor cells (EPCs) are one of the most important stem cells for the neovascularization of tissues damaged by ischemic diseases such as myocardial infarction, ischemic stroke, or critical limb ischemia. However, their low homing effic
Externí odkaz:
https://doaj.org/article/4b439f7ec8e94e89bc4086d8250378f5