Multimorbidity clustering of the emergency department patient flow: Impact analysis of new unscheduled care clinics

Autor: Thomas Monneret, Ghilain Solivau, Adrien Wartelle, Hélène Questiaux, Jan Chrusciel, Farouk Yalaoui, Antoine Duclos, Stéphane Sanchez, David Laplanche, Farah Mourad-Chehade

Publikováno v: PLoS ONE
PLoS ONE, 2022, 17 (1), pp.e0262914. ⟨10.1371/journal.pone.0262914⟩
PLoS ONE, Vol 17, Iss 1, p e0262914 (2022)
PLoS ONE, Vol 17, Iss 1 (2022)

Background In France, the number of emergency department (ED) admissions doubled between 1996 and 2016. To cope with the resulting crowding situation, redirecting patients to new healthcare services was considered a viable solution which would spread

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49cae6a65776ad63f483ba6337dc1c8c
https://utt.hal.science/hal-03622700

Engineering gene overlaps to sustain genetic constructs in vivo

Autor: Chantal Lotton, Ariel B. Lindner, Thomas A. Meiller-Legrand, Arnaud Gutierrez, Antoine L. Decrulle, Antoine Frénoy, Aude Bernheim

Publikováno v: PLoS Computational Biology, Vol 17, Iss 10, p e1009475 (2021)
PLoS Computational Biology

Evolution is often an obstacle to the engineering of stable biological systems due to the selection of mutations inactivating costly gene circuits. Gene overlaps induce important constraints on sequences and their evolution. We show that these constr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b3c6a92433c5fdeababc79b5fc8aa6
https://doaj.org/article/f2bd32c24ae24d3ca118ea95cdf465b0

Emergence of co-expression in gene regulatory networks

Autor: Humberto Gutierrez, Wencheng Yin, Araxi O. Urrutia, Jimena Monzón-Sandoval, Luis Mendoza

Publikováno v: PLoS ONE
PLoS ONE, Vol 16, Iss 4, p e0247671 (2021)

Transcriptomes are known to organize themselves into gene co-expression clusters or modules where groups of genes display distinct patterns of coordinated or synchronous expression across independent biological samples. The functional significance of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e24f0240c1e3252a75c4a03ec4b9b55e
https://pubmed.ncbi.nlm.nih.gov/33793561

Precise determination of input-output mapping for multimodal gene circuits using data from transient transfection

Autor: Stelzer, Christoph, Benenson, Yaakov

Publikováno v: PLoS Computational Biology
PLoS Computational Biology, Vol 16, Iss 11, p e1008389 (2020)
PLoS Computational Biology, 16 (11)

The mapping of molecular inputs to their molecular outputs (input/output, I/O mapping) is an important characteristic of gene circuits, both natural and synthetic. Experimental determination of such mappings for synthetic circuits is best performed u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a8085bf60e8113d33f4006bf572afbb
https://pubmed.ncbi.nlm.nih.gov/33253149

Data-driven modeling predicts gene regulatory network dynamics during the differentiation of multipotential hematopoietic progenitors

Autor: Joanna E. Handzlik, null Manu

Publikováno v: PLoS Computational Biology, Vol 18, Iss 1, p e1009779 (2022)
PLoS Computational Biology

Cellular differentiation during hematopoiesis is guided by gene regulatory networks (GRNs) comprising transcription factors (TFs) and the effectors of cytokine signaling. Based largely on analyses conducted at steady state, these GRNs are thought to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82a5857c700aada45f73bdbecf169380
https://doi.org/10.1371/journal.pcbi.1009779